An overview on the synthesis of carbohydrate-based molecules with biological activity related to neurodegenerative diseases

Abstract

In the context of the search for multitarget drugs with improved efficacy against neurodegenerative disorders, carbohydrate derivatives have emerged as promising candidates for Alzheimer's therapy. Herein we describe the synthesis...

Organic selenocompounds: are they the panacea for human illnesses?

“…, with biological activities have been synthesized in different laboratories. 125,179–208 Unfortunately, they have been rarely tested in models related to their recognized biological effects. For instance, in a recent elegant and rational study, 209 the neurochemical behavior of selenofluoxetine was compared with fluoxetine by quantifying the cerebral (hippocampal) serotonin levels in living mice.…”

Crystal structure of 5-(β-D-glucopyranosylthio)-N-(4-methylphenyl)-1,3,4-thiadiazol-2-amine

“…There has been considerable recent interest in the chemistry of compounds involving both heterocyclic and carbohydrate moieties (Lopes et al, 2021). Heterocyclic thioglycosides are promising candidates in synthetic carbohydrate research, and some of these compounds have displayed various antagonistic activities (Abu-Zaied et al, 2011, 2019.…”

Stereoselective Synthesis of Nojirimycin α-C-Glycosides from a Bicyclic Acyliminium Intermediate: A Convenient Entry to N,C-Biantennary Glycomimetics

“… 15 , 16 Innate immune response signaling routes, 17 , 18 cell proliferation and metastasis, 19 or age-related neurodegenerative disorders, e.g. Alzheimer and Parkinson diseases, 20 , 21 can also be targeted with iminosugars. The recent reports on the promise of the piperidine- and indolizidine-type iminosugars 1-deoxynojirimycin (DNJ; 1 ) and castanospermine (CS; 2 ), respectively, and some of their derivatives for treating patients infected with SARS-CoV-2, the causative agent of the Covid-19 worldwide pandemic, attest to the unrelenting interest in the therapeutic potential of this amazing family of glycomimetics ( Figure 1 ).…”

“…These processes cause from major global health problems, for instance diabetes or cystic fibrosis, to highly disabling rare syndromes such as the lysosomal storage disorders Gaucher, Pompe, G M1 -gangliosidosis, and Fabry diseases. − Disrupting the activity of carbohydrate-processing enzymes in pathogens can be further exploited in fighting infectious diseases: e.g., viral infections. , Innate immune response signaling routes, , cell proliferation and metastasis, or age-related neurodegenerative disorders, e.g. Alzheimer and Parkinson diseases, , can also be targeted with iminosugars. The recent reports on the promise of the piperidine- and indolizidine-type iminosugars 1-deoxynojirimycin (DNJ; 1 ) and castanospermine (CS; 2 ), respectively, and some of their derivatives for treating patients infected with SARS-CoV-2, the causative agent of the Covid-19 worldwide pandemic, attest to the unrelenting interest in the therapeutic potential of this amazing family of glycomimetics (Figure ).…”