An R0-resectable, Genetically Engineered Mouse Model of Pancreatic Cancer Mimics the Response to Neoadjuvant Chemotherapy in Human PDAC

Abstract

0.036). Based on final histology, pancreatic resection could be avoided in 145/461 patients (31.5%). The rate of "unrequested surgery" changed significantly over the years (p= 0.033) and was related with age (p <0.001) , an elevated Ca 19-9 (p= 0.012), cyst dimension (p= 0.023) and type of operation (p <0.001). Conclusions: EUS is an effective procedure in the diagnostic management of PCN, influencing in this series the diagnostic accuracy. Nevertheless, it does not seem to be able to reduce surgical overtreatment. Risk of "unrequested surgery" reduced over the years and it seems correlated with the type of pancreatic resection, being higher for distal pancreatectomies.