An RF/microwave microfluidic sensor for miniaturized dielectric spectroscopy based on sensor transmission characteristics

Suster, Michael A.; Maji, Debnath; Vitale, Nicholas; Gürkan, Umut A.; Mohseni, Pedram

doi:10.1109/icsens.2015.7370678

Cited by 7 publications

(1 citation statement)

References 9 publications

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“…Microwave sensing technology has recently been adopted in a myriad of applications including ice sensing 24,25 , liquid and gas sensing [26][27][28][29] , dielectric spectroscopy [30][31][32] , monitoring cancer 33,34 , detection of glucose and electrolyte level in aqueous solutions 35,36 , and recently in clinical microbiology practices [37][38][39][40][41][42][43][44][45] . Microwave resonators have recently shown to be highly sensitive in sensing and monitoring bacteria 39,40,46,47 .…”

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confidence: 99%

Rapid and real-time monitoring of bacterial growth against antibiotics in solid growth medium using a contactless planar microwave resonator sensor

Jain

Nadaraja

Narang

et al. 2021

Sci Rep

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Infection diagnosis and antibiotic susceptibility testing (AST) are pertinent clinical microbiology practices that are in dire need of improvement, due to the inadequacy of current standards in early detection of bacterial response to antibiotics and affordability of contemporarily used methods. This paper presents a novel way to conduct AST which hybridizes disk diffusion AST with microwave resonators for rapid, contactless, and non-invasive sensing and monitoring. In this research, the effect of antibiotic (erythromycin) concentrations on test bacterium, Escherichia coli (E. coli) cultured on solid agar medium (MH agar) are monitored through employing a microwave split-ring resonator. A one-port microwave resonator operating at a 1.76 GHz resonant frequency, featuring a 5 mm2 sensitive sensing region, was designed and optimized to perform this. Upon introducing uninhibited growth of the bacteria, the sensor measured 0.005 dB/hr, with a maximum change of 0.07 dB over the course of 15 hours. The amplitude change decreased to negligible values to signify inhibited growth of the bacteria at higher concentrations of antibiotics, such as a change of 0.005 dB in resonant amplitude variation while using 45 µg of antibiotic. Moreover, this sensor demonstrated decisive results of antibiotic susceptibility in under 6 hours and shows great promise to expand automation to the intricate AST workflow in clinical settings, while providing rapid, sensitive, and non-invasive detection capabilities.

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