An SNP is used to map MC1R to dog chromosome 5

Schmutz, S. M.; Moker, J. S.; Berryere, T. G.; Christison, K. M.; Dolf, G.

doi:10.1111/j.1365-2052.2001.0647d.pp.x

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Melanocortin 1 receptor ( MC1R ) was the first gene studied using molecular approaches in dogs. MC1R was mapped to CFA5, 6 cM from ZuBeCa 6 (Schmutz et al. 2001a).…”

Section: Basic Coat Colour Loci In Dogsmentioning

confidence: 99%

Genes affecting coat colour and pattern in domestic dogs: a review

2007

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Tremendous progress has been made in identifying genes involved in pigmentation in dogs in the past few years. Comparative genomics has both aided and benefited from these findings. Seven genes that cause specific coat colours and/or patterns in dogs have been identified: melanocortin 1 receptor, tyrosinase related protein 1, agouti signal peptide, melanophilin, SILV (formerly PMEL17), microphthalmia-associated transcription factor and beta-defensin 103. Although not all alleles have been yet identified at each locus, DNA tests are available for many. The identification of these alleles has provided information on interactions in this complex set of genes involved in both pigmentation and neurological development. The review also discusses pleiotropic effects of some coat colour genes as they relate to disease. The alleles found in various breeds have shed light on some potential breed development histories and phylogenetic relationships. The information is of value to dog breeders who have selected for and against specific colours since breed standards and dog showing began in the late 1800s. Because coat colour is such a visible trait, this information will also be a valuable teaching resource.

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“…Melanocortin 1 receptor ( MC1R ) was the first gene studied using molecular approaches in dogs. MC1R was mapped to CFA5, 6 cM from ZuBeCa 6 (Schmutz et al. 2001a).…”

Section: Basic Coat Colour Loci In Dogsmentioning

confidence: 99%

Genes affecting coat colour and pattern in domestic dogs: a review

2007

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“…Whether canine follicular melanocytes synthesize red/yellow pheomelanin or black/brown eumelanin is determined by a small set of genes. Among the candidate genes for dog coat-color variation (Schmutz and Berryere, 2007), the melanocortin 1 receptor gene (MC1R), which is located on chromosome 5 (Schmutz et al, 2001), is a candidate gene that influences coat color (Everts et al, 2000;Newton et al, 2000). MC1R corresponds to an extension locus (E; Little, 1957), and three alleles (E/E M /e) have been reported.…”

Section: Introductionmentioning

confidence: 99%

Melanocyte-stimulating Hormone Receptor (MC1R) Genotype and Its Effects on Coat Color in Korean Jindo Dogs

Hong¹,

Kim²,

Jang³

et al. 2009

Asian Australas. J. Anim. Sci

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The Jindo dog is a Korean natural monument and is recognized by the Fédération Cynologique Internationale. A prominent feature is the diverse coat color within the breed. To analyze the genetic basis of variation in the Jindo coat color, we sequenced the protein-coding regions of the melanocortin 1 receptor gene (MC1R). The MC1R coding sequence was determined from 154 dogs in five breeds (Jindo, Labrador Retriever, English Springer Spaniel, Belgian Malinois, and German Shepherd). To confirm the genetic structure of sampled populations, we tested for Hardy-Weinberg equilibrium (HWE) and computed F st . The sample populations did not significantly deviate from HWE. F st was 0.02 between white and fawn Jindo dogs; this was lower than F st between breeds. Six single nucleotide polymorphisms (SNPs) were detected in the MC1R coding region. Among the six SNPs, five were non-synonymous (S90G, T105A, Q159P, M264V, and R306ter) and one was synonymous SNP (Y298Y). From the SNPs, we predicted four haplotypes (H1, H2, H3, and H4) for Jindo MC1R. Jindo dogs had different haplotypes corresponding to different coat colors. H1 was frequently observed in white Jindo dogs with an odds ratio of 5.03 (95% CI: 2.27-11.18, p<0.0001), whereas H2 and H4 were observed only in fawn Jindo dogs. Our findings indicate that SNP haplotype can influence coat color. Knowledge of MC1R haplotypes can help discriminate white and fawn coats in Jindo dogs. We hope this report will trigger more research into the genetics of this traditional Korean dog and will be a reference for dogs of Asian origin. Also, our results will provide a useful genetic marker for Jindo dog breeders who have selected for specific colors.

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An SNP is used to map MC1R to dog chromosome 5

Cited by 2 publications

References 8 publications

Genes affecting coat colour and pattern in domestic dogs: a review

Genes affecting coat colour and pattern in domestic dogs: a review

Melanocyte-stimulating Hormone Receptor (MC1R) Genotype and Its Effects on Coat Color in Korean Jindo Dogs

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