An ultra-sensitive electrochemical biosensor for circulating tumor DNA utilizing dual enzyme-assisted target recycle and hybridization chain reaction amplification strategies

Huang, Shan; Liu, Shuai; Fang, Yi; Li, Huihao; Yang, Mingli; Wang, Wei; Chen, Sijing; Xiao, Qi

doi:10.1016/j.microc.2024.111164

Microchemical Journal

2024

DOI: 10.1016/j.microc.2024.111164

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An ultra-sensitive electrochemical biosensor for circulating tumor DNA utilizing dual enzyme-assisted target recycle and hybridization chain reaction amplification strategies

Shan Huang,

Shuai Liu,

Yi Fang

et al.

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2024

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Cited by 2 publications

References 39 publications

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A bimetallic PtAu-modified carbon fiber electrochemical sensor for simultaneous and highly sensitive detection of catechol and hydroquinone in environmental water

Xiao,

Li,

Yang

et al. 2024

Anal. Methods

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A bimetallic PtAu-modified carbon fiber electrochemical sensor for simultaneous and highly sensitive detection of catechol and hydroquinone in environmental water

Xiao,

Li,

Yang

et al. 2024

Anal. Methods

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Emerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized Medicine

Kalligosfyri,

Lamprou,

Kalogianni

2024

Sensors

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Liquid biopsy is an efficient diagnostic/prognostic tool for tumor-derived component detection in peripheral circulation and other body fluids. The rapid assessment of liquid biopsy techniques facilitates early cancer diagnosis and prognosis. Early and precise detection of tumor biomarkers provides crucial information about the tumor that guides clinicians towards effective personalized medicine. Point-of-care-testing remains still a great challenge in cancer diagnostics. Liquid biopsy is a promising alternative to tissue biopsy with the great advantages of less invasion and real-time monitoring of the disease, also providing information about tumor heterogeneity. The field is continuously and rapidly expanding. Numerous sophisticated biosensors have been developed targeting several biomarkers to achieve low detection limits, increased specificity and robustness. Current biosensors include mainly optical sensors, such as colorimetric, fluorescent, SPR, SERS and lateral flow assays. Electrochemical sensors have also been developed, providing very low detection limits. Colorimetric sensors exhibited simplicity in signal interpretation, while fluorescent sensors contributed to low analysis times, and SPR/SERS enabled label-free and rapid analysis. Novel target amplification and signal enhancement techniques have been exploited to increase the detectability of the sensors. In this context, this review is focused on the recent advances in biosensing technology for cutting-edge liquid biopsy applications towards point-of-care testing.

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An ultra-sensitive electrochemical biosensor for circulating tumor DNA utilizing dual enzyme-assisted target recycle and hybridization chain reaction amplification strategies

Cited by 2 publications

References 39 publications

A bimetallic PtAu-modified carbon fiber electrochemical sensor for simultaneous and highly sensitive detection of catechol and hydroquinone in environmental water

A bimetallic PtAu-modified carbon fiber electrochemical sensor for simultaneous and highly sensitive detection of catechol and hydroquinone in environmental water

Emerging Sensing Technologies for Liquid Biopsy Applications: Steps Closer to Personalized Medicine

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