An ultra-sensitive fluorescent Aptamer sensor based on 2D MOF for detection of HER2 in serum

Li, Ning; Zhang, Ya; Xu, Ying; Liu, Xiaofang; Yang, ZhiHao; Wang, Qun; Yang, Mei; Hou, Changjun; Huo, Danqun

doi:10.1016/j.microc.2023.109426

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…565,566 Triethylamine can be used as a solvent in the synthesis of nano-based materials. 567,568 Nanosensors have also been developed to detect presence and levels of triethylamine considered an environmental pollutant. 569,570 Dimethylformamide (DMF) 571,572 is also often used as solvent in synthesis.…”

Section: Institute Of Science and Technology (Kist)mentioning

confidence: 99%

Nanoscale materials at work: Mapping emerging applications in energy, medicine, and beyond

Hughes,

Ganesan,

Tenchov

et al. 2024

Preprint

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Since their inception in the early 1960s, the use of nanoscale materials has progressed in leaps and bounds, and their role in diverse fields ranging from human health to energy is undeniable. In this report, we utilize the CAS Content Collection, a vast repository of scientific information extracted from journal and patent publications, to identify emerging topics in this field. This involves understanding trends, such as the growth of certain topics over time, as well as establishing relationships between emerging topics. We achieved this by using a host of strategies including a quantitative natural language processing (NLP) approach to identify 279 emerging topics and sub-topics across three major categories – materials, applications, and properties – by surveying roughly 3 million publications in the nanoscience landscape. This wealth of information has been condensed into several conceptual mind maps and other graphs that provide metrics related to the growth of identified emerging concepts, group them into hierarchical classes, and explore the connections between them. We delved deeper into four major emerging applications of nanoscale materials – drug delivery, sensors, energy, and catalysis – to provide a more comprehensive and detailed picture of the use of nanotechnology in these fields. In addition, we leveraged the CAS registry, consisting of over 250 million substances, to determine and discover substances across varied classes (such as polymers, elements, organic/inorganic molecules) and how they are utilized in the 4 major applications. Our extensive analysis taking advantage of an NLP-based approach along with robust CAS indexing provides valuable insights in the field that we hope can help to inform and drive future research efforts.

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Section: Institute Of Science and Technology (Kist)mentioning

confidence: 99%

Nanoscale materials at work: Mapping emerging applications in energy, medicine, and beyond

Hughes,

Ganesan,

Tenchov

et al. 2024

Preprint

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“…3−5 Therefore, it is necessary to achieve accurate early detection of HER2. In recent years, there have been numerous advancements in the development of detection methods for HER2, for example, electrochemical immunoassay, 6 fluorescence, 7 enzyme-linked immunosorbent assay, 8 and so on. However, there are some disadvantages, such as high detection cost, complex operation, and low sensitivity.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Human epidermal growth factor receptor-2 (HER2) is the most well-established marker studied in human breast cancer (BC). , When HER2 is overexpressed and the gene is amplified in the human body, the risk of BC is greatly increased because HER2 will regulate cell expansion and differentiation. − Therefore, it is necessary to achieve accurate early detection of HER2. In recent years, there have been numerous advancements in the development of detection methods for HER2, for example, electrochemical immunoassay, fluorescence, enzyme-linked immunosorbent assay, and so on. However, there are some disadvantages, such as high detection cost, complex operation, and low sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Immunosensor Platform for Sensitive Detection of Human Epidermal Growth Factor Receptor-2 Based on Enhanced Cathode Electrochemiluminescence of Bimetallic Nanoclusters

Liu,

Zhang,

Feng

et al. 2024

Anal. Chem.

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In this work, a microfluidic immunosensor chip was developed by incorporating microfluidic technology with electrochemiluminescence (ECL) for sensitive detection of human epidermal growth factor receptor-2 (HER2). The immunosensor chip can achieve robust reproducibility in mass production by integrating multiple detection units in a series. Notably, nanoscale materials can be better adapted to microfluidic systems, greatly enhancing the accuracy of the immunosensor chip. Ag@Au NCs closed by glutathione (GSH) were introduced in the ECL microfluidic immunosensor system with excellent and stable ECL performance. The synthesized CeO2–Au was applied as a coreaction promoter in the ECL signal amplification system, which made the result of HER2 detection more reliable. In addition, the designed microfluidic immunosensor chip integrated the biosensing system into a microchip, realizing rapid and accurate detection of HER2 by its high throughput and low usage. The developed short peptide ligand NARKFKG (NRK) achieved an effective connection between the antibody and nanocarrier for improving the detection efficiency of the sensor. The immunosensor chip had better storage stability and sensitivity than traditional detection methods, with a wide detection range from 10 fg·mL–1 to 100 ng·mL–1 and a low detection limit (LOD) of 3.29 fg·mL–1. In general, a microfluidic immunosensor platform was successfully constructed, providing a new idea for breast cancer (BC) clinical detection.

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Nanoengineering multifunctional organized systems highlighting hybrid micelles, vesicles and lipidic aggregates towards higher sized structures for theranostics perspectives

Inda,

Martinez,

Tettamanti

et al. 2025

Theranostics Nanomaterials in Drug Delivery

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An ultra-sensitive fluorescent Aptamer sensor based on 2D MOF for detection of HER2 in serum

Cited by 4 publications

References 26 publications

Nanoscale materials at work: Mapping emerging applications in energy, medicine, and beyond

Nanoscale materials at work: Mapping emerging applications in energy, medicine, and beyond

Microfluidic Immunosensor Platform for Sensitive Detection of Human Epidermal Growth Factor Receptor-2 Based on Enhanced Cathode Electrochemiluminescence of Bimetallic Nanoclusters

Nanoengineering multifunctional organized systems highlighting hybrid micelles, vesicles and lipidic aggregates towards higher sized structures for theranostics perspectives

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