An ultrasensitive heart-failure BNP biosensor using B/N co-doped graphene oxide gel FET

Efficacy of graphene oxide-loaded cationic antimicrobial peptide AWRK6 on the neutralization of endotoxin activity and in the treatment of sepsis

“…GO is a new type of active material that contains a large number of oxygen-containing functional groups, characterized by a positive biological activity, an excellent hydrophilicity and a stable dispersity in water, which is widely used in the chemical and medical areas [19]. Biodistribution analysis revealed that GO presented in mice brain, spleen, liver, kidney and bone marrow within a month after injection [20].…”

Recent advances of graphene–biomacromolecule nanocomposites in medical applications

“…Novodchuk et al prepared BNP covalently functionalized B/N co-doped GO gels to fabricate BNP field effect transistor (FET) biosensors for the targeted detection of BNP. 107 The biosensor, which was able to detect BNP within 2 minutes with the lowest limit of detection of 10 aM and a large detection range which stretches over 11 orders of magnitude (10 aM–1 μM) in buffer solution, was a sensitive and rapid bio-platform for BNP detection and played a very important role in the early diagnosis of HF.…”

Multifunctional carbon nanomaterials for diagnostic applications in infectious diseases and tumors

“…On the other hand, ordinary graphene and GO have a small band gap energy and lose their FET properties with little or no gate interaction. However, it has been found that doping graphene/GO with appropriate amounts of impurity elements can change their semiconductor electrical properties, leading to FET behavior with gate response [ 61 ]. Therefore, graphene/GO-based FET sensors lay the foundation for biomolecular sensing, especially for the rapid detection of SARS-CoV-2.…”