An ultrasensitive SERS sensor for simultaneous detection of multiple cancer-related miRNAs

Song, Chunyuan; Yang, Yanjun; Yang, Boyue; Sun, Youzhi; Zhao, Yiping; Wang, L. H.

doi:10.1039/c6nr05504d

Cited by 111 publications

(55 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An ultrasensitive SERS substrate was developed for the detection of multiple microRNA (miRNA) biomarkers for lung cancer using molecular beacons attached to the surface of an Ag nanorod array. This sensor was able to detect attomolar concentrations of the miRNA sequences in human serum, creating the potential for use of this substrate as a clinical lung cancer detection mechanism [ 102 , 103 ].…”

Section: Cancermentioning

confidence: 99%

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

et al. 2018

View full text Add to dashboard Cite

For many disease states, positive outcomes are directly linked to early diagnosis, where therapeutic intervention would be most effective. Recently, trends in disease diagnosis have focused on the development of label-free sensing techniques that are sensitive to low analyte concentrations found in the physiological environment. Surface-enhanced Raman spectroscopy (SERS) is a powerful vibrational spectroscopy that allows for label-free, highly sensitive, and selective detection of analytes through the amplification of localized electric fields on the surface of a plasmonic material when excited with monochromatic light. This results in enhancement of the Raman scattering signal, which allows for the detection of low concentration analytes, giving rise to the use of SERS as a diagnostic tool for disease. Here, we present a review of recent developments in the field of in vivo and in vitro SERS biosensing for a range of disease states including neurological disease, diabetes, cardiovascular disease, cancer, and viral disease.

show abstract

Section: Cancermentioning

confidence: 99%

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Using this process, single nucleotide polymorphism has been detected in BRCA1 gene . Multiplexed SERS detection of serum miRNAs in lung cancer has been demonstrated using DNA hairpin aptamer‐coated AgNR array …”

Section: In Vitro Detection Of Biomarkers With Sers For Cancer Diagnomentioning

confidence: 99%

“…The dose‐response relation was quantified based on 386‐cm −1 band intensity of 4‐FBT. Inset shows the SERS spectra of PSA for respective methods, reprinted from Song et al Copyright American Chemical Society. (a) Ratio‐metric quantification of f‐PSA to t‐PSA for prostate cancer diagnosis.…”

Section: In Vitro Detection Of Biomarkers With Sers For Cancer Diagnomentioning

confidence: 99%

Advances in surface‐enhanced Raman spectroscopy for cancer diagnosis and staging

Chakraborty

Ghosh

Barui

2019

J Raman Spectroscopy

View full text Add to dashboard Cite

Surface‐enhanced Raman spectroscopy (SERS) is rapidly emerging as a bioanalytical tool for cancer diagnosis and therapy. The SERS‐based molecular diagnostics have progressed from proof‐of‐concept studies towards analysis in animal models as well as for in vitro clinical diagnostics in the last decade. Recently, SERS has also been implemented in screening, diagnosis, and staging of clinical cancer samples. Moreover, in vivo SERS imaging has been implemented for mapping the extent of tumor growth and metastasis; SERS nanoparticles have also enabled image‐guided therapies strongly indicating SERS technology can significantly complement the practice of oncology. Despite the progress, widespread clinical translation of SERS nanoparticles is still challenging. Current SERS strategies in diagnostic oncology require further development and standardization to progress from bench‐top to point‐of‐care applications. The present review critically analyzes the current state of the art about various strategies for SERS‐based cancer detection and staging from cellular metabolites, exosomes, circulating tumor cells, extracellular fluids, and cancer cells.

show abstract

“…So far colloidal nanoparticles of various shapes and sizes have been extensively used in SERS; however, the lack of control over their relative orientation and separation limits efficient plasmonic coupling therebetween . While this issue is addressed in SERS substrates made of immobilized nanoparticles, interparticle gaps in these substrates are typically optimized to generate maximum field confinement for single wavelengths. Broadband SERS substrates can be made by immobilizing a mixture of nanoparticles resonant over a range of laser wavelengths on surface plasmon polariton (SPP)‐supporting thin films .…”

Section: Introductionmentioning

confidence: 99%

Multiwavelength Surface‐Enhanced Raman Spectroscopy Using Rainbow Trapping in Width‐Graded Plasmonic Gratings

Kazemi-Zanjani

Shayegannia

Prinja

et al. 2018

Advanced Optical Materials

View full text Add to dashboard Cite

as plasmonic hot-spots. [2] The resulting spectroscopic technique, known as surface-enhanced Raman spectroscopy (SERS), [3] surpasses the inherently low sensitivity of Raman by counterbalancing its low scattering efficiency [4] through spatial localization of the sample molecules proximal to the hot-spots on SERS substrates. So far colloidal nanoparticles of various shapes and sizes have been extensively used in SERS; [5][6][7][8][9] however, the lack of control over their relative orientation and separation limits efficient plasmonic coupling therebetween. [10] While this issue is addressed in SERS substrates made of immobilized nanoparticles, [11][12][13][14] interparticle gaps in these substrates are typically optimized to generate maximum field confinement for single wavelengths. Broadband SERS substrates can be made by immobilizing a mixture of nanoparticles resonant over a range of laser wavelengths on surface plasmon polariton (SPP)-supporting thin films. [15,16] However, the magnitude of SERS signal enhancement and the broadband nature of such substrates remain highly dependent on the nanoparticle-film separation as well as the interparticle distances which are difficult to control in practice. More robust broadband SERS substrates have been recently fabricated by sputtering randomly sized silver nanoparticles on glass-silver-glass multilayered substrates, [17] yielding plasmonic resonances over the 400-1100 nm

show abstract

An ultrasensitive SERS sensor for simultaneous detection of multiple cancer-related miRNAs

Cited by 111 publications

References 40 publications

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

In Vitro and In Vivo SERS Biosensing for Disease Diagnosis

Advances in surface‐enhanced Raman spectroscopy for cancer diagnosis and staging

Multiwavelength Surface‐Enhanced Raman Spectroscopy Using Rainbow Trapping in Width‐Graded Plasmonic Gratings

Contact Info

Product

Resources

About