An ultraviolet spectrophotometric procedure for the routine determination of naproxen

Holzbecher, M.; Ellenberger, H. A.; Marsh, J M; Boudreau, S.

doi:10.1016/s0009-9120(79)80010-7

Cited by 15 publications

(11 citation statements)

References 6 publications

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“…Naproxen's determination is carried out normally through HPLC coupled to UV detector as reported in the Mexican Pharmacopeia 2011 (4) and in the United States Pharmacopeia 2003 (5)(6)(7)(8). Also, there are other techniques reported like capillary electrophoresis (9), spectrophotometry (10,11), spectrofluorimetry (12,13) and chemiluminescence (14,15). The majority of these techniques are demandingly laborious and time-consuming mostly because of their inherent response periods, require expensive main and ancillary instrumentation, also the sample needs prior derivatization and most of them use organic solvents.…”

Section: Introductionmentioning

confidence: 99%

New Insights on Naproxen Quantification Using Voltammetry and Graphite Electrodes: Development of an Optimized and Competitive Methodology

et al. 2015

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The present work describes a novel, simple and fast electroanalytical methodology for naproxen determination in pharmaceutical formulations. Naproxen's indirect quantification through an adsorption anodic wave was performed at a graphite bar electrode using differential pulse voltammetry. An anodic current maximum was recorded at a potential of -0.3 V referred to a saturated Ag/AgCl electrode, in the presence of 0.1 mol L -1 phosphates buffer at pH 7 as supporting electrolyte. The naproxen's oxidation is an irreversible diffusion-controlled process. A calibration plot was done from which a correlation coefficient of 0.990 was obtained with a sensibility of 4.19 ± 0.62 µA L µg -1 , detection and quantification limits of 2.99 and 9.97 µg L -1 respectively.

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Section: Introductionmentioning

confidence: 99%

New Insights on Naproxen Quantification Using Voltammetry and Graphite Electrodes: Development of an Optimized and Competitive Methodology

et al. 2015

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“…However, a recent study classified naproxen as the least harmful NSAID in cardiovascular terms. 3 Different analytical methods have been proposed for the determination of naproxen in pharmaceutical formulations including spectrophotometry (UV region), 4,5 spectrofluorimetry, [6][7][8] capillary isotachophoresis 9 and high-performance liquid-chromatography (HPLC) coupled with spectrophotometric, 10 amperometric 11 and mass spectrometric detectors. 1 Nevertheless, these analytical methods require expensive equipment and reagents, are time-consuming and often necessitate laborious pre-and post-column derivatization procedures.…”

Section: Introductionmentioning

confidence: 99%

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

Stefano¹,

Lima²,

Montes³

et al. 2012

J. Braz. Chem. Soc.

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Um método eletroanalítico original e rápido para a determinação de naproxeno em formulações farmacêuticas usando análise por injeção em batelada (BIA) com detecção amperométrica pulsada é descrito. Eletrodo de carbono vítreo foi usado como eletrodo de trabalho e solução tampão fosfato 0,05 mol L -1 como eletrólito suporte. O método amperométrico envolveu a aplicação contínua de dois pulsos de potencial ao eletrodo de trabalho com intuito de detectar naproxeno pela sua oxidação eletroquímica (+1,5 V por 200 ms) e de limpar a superfície do eletrodo de produtos de adsorção (+1,0 V por 100 ms), evitando contaminação do eletrodo. O método proposto possui várias vantagens para análises de rotina, incluindo: baixo desvio padrão relativo (3,0%, n = 10), elevada frequência analítica (90 h -1 ), exatidão satisfatória (baseado em determinações comparativas por espectrofluorimetria) e baixo limite de detecção (0,3 µmol L -1 ).A novel and fast electroanalytical method for naproxen determination in pharmaceutical formulations using batch injection analysis (BIA) with pulsed amperometric detection is described. Bare glassy carbon electrode was used as working electrode and 0.05 mol L -1 phosphate buffer solution as supporting electrolyte. The amperometric method involved the continuous application of two sequential potential pulses to the working electrode in order to detect naproxen by its electrochemical oxidation (+1.5 V for 200 ms) and to clean the electrode surface from adsorption products (+1.0 V for 100 ms), avoiding electrode contamination. The proposed method has several advantages for routine analysis, including: a low relative standard deviation between injections (3.0%, n = 10), high analytical frequency (90 h -1 ), satisfactory accuracy (based on comparative determinations by spectrofluorimetry) and low limit of detection (0.3 µmol L -1 ).Keywords: batch injection analysis, multiple-pulse amperometry, non-steroidal antiinflammatory drug IntroductionNaproxen, 2-(6-methoxynaphthalen-2-yl) propanoic acid, is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and has been widely used as an over-the-counter analgesic, anti-inflammatory and antipyretic agent. It is also commonly used for the reduction of stiffness caused by conditions including kidney stones, rheumatoid arthritis and other inflammatory rheumatic diseases. 1,2 NSAIDs have been associated with the increasing number of potentially cardiovascular events. However, a recent study classified naproxen as the least harmful NSAID in cardiovascular terms. 3 Different analytical methods have been proposed for the determination of naproxen in pharmaceutical formulations including spectrophotometry (UV region), 4,5 spectrofluorimetry, 6-8 capillary isotachophoresis 9 and high-performance liquid-chromatography (HPLC) coupled with spectrophotometric, 10 amperometric 11 and mass spectrometric detectors. 1 Nevertheless, these analytical methods require expensive equipment and reagents, are time-consuming and often necessitate laborious pre-and pos...

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“…The non‐steroidal anti‐inflammatory drug naproxen, (+)‐2‐(6‐methoxy‐2‐naphthyl) propionic acid, is widely consumed by population and due to its improper disposal, microgram‐per‐liter concentration of this compound was found in natural waters and in sewage treatment plant effluents 1. Analytical methods have been developed for naproxen determination in pharmaceutical samples including UV spectrophotometry 2, 3, spectrofluorimetry 4, 5, and high‐performance liquid‐chromatography (HPLC) 6–9. Most of these analytical methods require expensive equipment and reagents and are time‐consuming.…”

mentioning

confidence: 99%

Exploring Multiwalled Carbon Nanotubes for Naproxen Detection

et al. 2014

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The electrochemical oxidation of naproxen was investigated at a multiwalled carbon nanotube (MWCNT)‐modified electrode. A decrease (200 mV) in the overpotential of the naproxen oxidation reaction and considerable (4‐fold) current increase (compared to the bare glassy‐carbon electrode) was observed. Two one‐electron transfers were verified at both bare and MWCNT‐modified electrodes and thus a new mechanism for the electrochemical oxidation of naproxen is proposed. Indicative of a mass transport regime that includes a thin‐layer diffusional process (entrapment of naproxen species within the MWCNT film) is presented as a possible explanation for the lowered oxidation potential and substantial current increase. The anti‐fouling properties of MWCNTs on the amperometric detection of naproxen using a batch‐injection analysis (BIA) system is demonstrated.

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An ultraviolet spectrophotometric procedure for the routine determination of naproxen

Cited by 15 publications

References 6 publications

New Insights on Naproxen Quantification Using Voltammetry and Graphite Electrodes: Development of an Optimized and Competitive Methodology

New Insights on Naproxen Quantification Using Voltammetry and Graphite Electrodes: Development of an Optimized and Competitive Methodology

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

Exploring Multiwalled Carbon Nanotubes for Naproxen Detection

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