1995
DOI: 10.1073/pnas.92.24.11140
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An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae.

Abstract: Competence for genetic transformation in Streptococcus pneumoniae has been known for three decades to arise in growing cultures at a critical cell density, in response to a secreted protease-sensitive signal. We show that strain CP1200 produces a 17-residue peptide that induces cells of the species to develop competence. The sequence of the peptide was found to be H-Glu-Met-Arg-Leu-Ser-Lys-Phe-Phe-ArgAsp-Phe-Ile-Leu-Gln-Arg-Lys-Lys-OH. A synthetic peptide of the same sequence was shown to be biologically activ… Show more

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Cited by 664 publications
(634 citation statements)
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“…The regulation of bacteriocin production in L. sake LTH673 bears striking similarities to the regulation of competence for genetic transformation in Streptococcus pneumoniae (Hå varstein et al, 1995b;1996;Pestova et al, 1996;Cheng et al, 1997). Both regulatory mechanisms involve an unmodified, basic peptide pheromone whose secretion is directed by a typical double-glycine leader peptide (Håvarstein et al, 1995b) and whose gene is co-transcribed with a two-component signal transduction system (Cheng et al, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…The regulation of bacteriocin production in L. sake LTH673 bears striking similarities to the regulation of competence for genetic transformation in Streptococcus pneumoniae (Hå varstein et al, 1995b;1996;Pestova et al, 1996;Cheng et al, 1997). Both regulatory mechanisms involve an unmodified, basic peptide pheromone whose secretion is directed by a typical double-glycine leader peptide (Håvarstein et al, 1995b) and whose gene is co-transcribed with a two-component signal transduction system (Cheng et al, 1997).…”
Section: Discussionmentioning
confidence: 99%
“…2) (22). Alternatively, some linear-peptide-based QS systems actively transport the autoinducers back into the cell where the peptide signal can interact directly with a cognate regulator to alter target gene expression.…”
Section: Peptide-based Quorum Sensingmentioning
confidence: 99%
“…CSP controls the natural genetic transformation of S. pneumoniae [13], with two overlapping waves of transcription of CSP-responsive genes, “early” and “late” competence genes. Those early genes participate in competence regulation and link signals to late gene expression [23], while deletion of late genes, such as coiA, celA , and celB , abolishes transformation [15,24].…”
Section: Discussionmentioning
confidence: 99%
“…When CSP is sensed, a transient shift in the transcriptome and proteome pattern is induced, which affects competence as well as pneumococcal virulence [13,14]. This transcriptional shift arises from two overlapping transcription waves of CSP-responsive genes, i.e.…”
Section: Introductionmentioning
confidence: 99%