An unquenchable thirst

Gallop, Amy

doi:10.12788/cp.0167

CP 2021

DOI: 10.12788/cp.0167

|View full text |Cite

An unquenchable thirst

Amy Gallop¹

Abstract: Mr. F, age 44, has schizophrenia that includes religious delusions. After a presumed seizure and fall, he develops delirium. What's causing these symptoms? DisclosuresThe authors report no financial relationships with any companies whose products are mentioned in this article, or with manufacturers of competing products.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The Neurokinin-1 Receptor: Structure Dynamics and Signaling

Rodríguez

Coveñas

2022

Receptors

View full text Add to dashboard Cite

Substance P (SP), the first isolated neuropeptide, belongs to the family of tachykinin peptides and is the natural ligand of neurokinin-1 receptors (NK-1R), also named SP receptors. The undecapeptide activates the receptor after specifically binding to the protein and triggers intracellular signals leading to different biochemical events and subsequent physiological responses. This study reviews the main architectural features of this receptor, its interaction with natural and synthetic ligands, and the functional conformational states adopted after interacting with ligands and effector G proteins. The analysis of the main intracellular signaling pathways turned on by the activation of NK-1 receptors reveals the participation of different proteins supporting metabolic changes and genetic and epigenetic regulations. Furthermore, the analysis of receptor occupancy and receptor downregulation and internalization represents a complex and estimable field for basic and clinical research focused on the role of SP in physiopathology. Profound knowledge of the structural dynamics of NK-1R may help develop and assay new selective synthetic non-peptide antagonists as potential therapeutic agents applied to various pathologies and symptoms.

show abstract

The Neurokinin-1 Receptor: Structure Dynamics and Signaling

Rodríguez

Coveñas

2022

Receptors

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

An unquenchable thirst

Cited by 1 publication

References 11 publications

The Neurokinin-1 Receptor: Structure Dynamics and Signaling

The Neurokinin-1 Receptor: Structure Dynamics and Signaling

Contact Info

Product

Resources

About