An Unsymmetrical Squaraine‐Based Activatable Probe for Imaging Lymphatic Metastasis by Responding to Tumor Hypoxia with MSOT and Aggregation‐Enhanced Fluorescent Imaging

Lin, Yi; Sun, Linhui; Zeng, Fang; Wu, Shuizhu

doi:10.1002/chem.201904675

Cited by 23 publications

(14 citation statements)

References 111 publications

(13 reference statements)

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“…Reproduced with permission: Copyright 2019, Wiley-VCH GmbH. [233] (F) Schematic illustration of the reaction of nanoprobe 99a with NTR in a tumor (top) and two image scenarios of breast tumor metastasis (bottom). Reproduced with permission: Copyright 2019, Wiley-VCH GmbH.…”

Section: Aiegens For Cathepsin Bmentioning

confidence: 99%

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

et al. 2021

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Activity‐based approaches for designing AIEgens possess prominent advantages including high selectivity, sensitivity, and signal‐to‐noise ratio, and they have received more attention in recent years. Excellent activatable AIE probes have been reported for detecting toxic substances, imaging intracellular active molecules/biomolecules, as well as monitoring the activity of overexpressed enzymes in cancers. Moreover, the majority of activatable theranostic AIEgens can be specifically triggered in cancer cells and can kill these cells under light irradiation, while they have no distinct effect on normal cells, demonstrating satisfactory therapeutic selectivity that is superior to that of traditional chemotherapy. Thus, in this review, we systematically summarized the development of activatable AIE bioprobes in recent years from molecular design principles to biological applications. The challenges of activatable AIE probes and the corresponding solutions are described. We hope that the information provided in this review will facilitate the design of more activatable AIE probes to promote practical application of corresponding AIEgens.

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Section: Aiegens For Cathepsin Bmentioning

confidence: 99%

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

et al. 2021

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“…Recently, quite a few NTR-activatable optical probes or theranostic systems have been reported. [38][39][40][41][42][43][44][45][46][47][48][49] The general working mechanisms are summarized in Figure 4.…”

Section: Reductasementioning

confidence: 99%

“…A number of activatable NIR FL probes (e.g., 7-9) have been successfully obtained by means of the nitro-to-amino transformation strategy, demonstrating the feasibility of this means. [44][45][46][47][48][49] The work shown in Figure 5 is a good example to the strategy I. The nanoprobe developed by Zeng and Wu et al through the self-assembly of Q-NO 2 (i.e., compound 10) is NTR-activatable for the imaging of breast cancer metastases via NIR-I/NIR-II FL imaging and MSOT imaging.…”

Section: Reductasementioning

confidence: 99%

Most recent advances on enzyme‐activatable optical probes for bioimaging

Mei

Tian

2021

Aggregate

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Enzymes are essential biological elements that play vital roles in many key cellular events and physiological processes. The dysregulation of enzyme activity broadly occurs in a large number of diseases ranging from inflammation to neurodegenerative disorders to tumors. Molecular imaging allows accurate and noninvasive visualization of biological analytes/physiological processes of interest closely linked to human health at different levels. Among various imaging modalities, optical imaging stands out benefited from its high sensitivity, excellent spatiotemporal resolution, real‐time mode, and facile accessibility. Diverse optical probes specifically activatable by disease‐relevant enzymes have sprung up. In comparison to the “always‐on” counterparts, the “off‐on” imaging probes activated by enzymes hold great promise for precise diagnosis of diseases at early stage with high target‐to‐background ratio, dramatically improved specificity, and significantly enhanced sensitivity. Herein, the most recent advances in optical probes activatable by enzymes for biosensing and bioimaging are briefly reviewed emphasizing their molecular design, working mechanism, and biomedical applications. Besides, some important prospects and the current challenges to fully implement the potential of enzyme‐activatable probes for precise and efficient theranostics in life science are also pointed out to hopefully arouse new insights into the development of new generation of theranostics.

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“…injection of the nanoprobe, PA imaging of a 4T1 subcutaneous tumor bearing mice displayed contrast at the tumor and indicated the hypoxic regions as a reflection of tumor heterogeneity. [211] A similar nanoparticle-based approach utilized bioreductive properties with azoreductase-responsive PA probes. Huang et al reported a xanthene dye conjugated to N-phenyldiethanolamine via an azo linker (NR-azo).…”

Section: Multispectral Photoacoustic Tomographymentioning

confidence: 99%

Nano versus Molecular: Optical Imaging Approaches to Detect and Monitor Tumor Hypoxia

Cheng

Zheng

2020

Adv Healthcare Materials

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Hypoxia is a ubiquitous feature of solid tumors, which plays a key role in tumor angiogenesis and resistance development. Conventional hypoxia detection methods lack continuous functional detection and are generally less suitable for dynamic hypoxia measurement. Optical sensors hereby provide a unique opportunity to noninvasively image hypoxia with high spatiotemporal resolution and enable real‐time detection. Therefore, these approaches can provide a valuable tool for personalized treatment planning against this hallmark of aggressive cancers. Many small optical molecular probes can enable analyte triggered response and their photophysical properties can also be fine‐tuned through structural modification. On the other hand, optical nanoprobes can acquire unique intrinsic optical properties through nanoconfinement as well as enable simultaneous multimodal imaging and drug delivery. Furthermore, nanoprobes provide biological advantages such as improving bioavailability and systemic delivery of the sensor to enhance bioavailability. This review provides a comprehensive overview of the physical, chemical, and biological analytes for cancer hypoxia detection and focuses on discussing the latest nano‐ and molecular developments in various optical imaging approaches (fluorescence, phosphorescence, and photoacoustic) in vivo. Finally, this review concludes with a perspective toward the potentials of these optical imaging approaches in hypoxia detection and the challenges with molecular and nanotechnology design strategies.

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An Unsymmetrical Squaraine‐Based Activatable Probe for Imaging Lymphatic Metastasis by Responding to Tumor Hypoxia with MSOT and Aggregation‐Enhanced Fluorescent Imaging

Cited by 23 publications

References 111 publications

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

Most recent advances on enzyme‐activatable optical probes for bioimaging

Nano versus Molecular: Optical Imaging Approaches to Detect and Monitor Tumor Hypoxia

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