An unusual syncope

Prado, Marta; Fiorelli, Elisa Maria; Tobaldini, Eleonora; Sandrone, Giulia; Montano, Nicola

doi:10.1007/s11739-012-0770-4

Cited by 4 publications

(7 citation statements)

References 8 publications

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“…Similarly, levothyroxine administration in hypothyroid patients induces a decrease in total and LDL cholesterol [16]. Moreover, TRT in hypogonadal males is able to influence metabolic parameters causing a reduction of fasting plasma glucose, HOMA-IR, triglycerides, waist circumference, and usually augmenting HDL cholesterol [19, 31–34]; also, estrogens, which increase after TRT due to aromatase-mediated conversion [35, 36], have been found to be positively associated with metabolic syndrome [37]. …”

Section: Discussionmentioning

confidence: 99%

“…Inclusion criteria were, (a) hypogonadotropic hypogonadism [19, 20] secondary to surgical removal of pituitary adenoma, (b) absence of hypophyseal adenoma hypersecretion before surgery, (c) absence of hypophyseal hormone deficit before surgery, (d) absence of hypogonadism before surgery, (e) presence of clinical follow-up data for the whole length of the study, and (f) absence of previous diseases able to condition metabolic parameters considered in this study (e.g., diabetes mellitus, dyslipidaemia, arterial hypertension, etc. ).…”

Section: Methodsmentioning

confidence: 99%

“…1000 mg of undecanoate testosterone was administered intramuscularly after 6 weeks before the first injection (loading dose), followed by similar injections every 10–14 weeks, depending on blood testosterone values and clinical symptoms [21]. All subjects presented both somatotropic and gonadotropic function deficits [19, 20, 22]; among them, four had also thyreotropic [23], two also corticotropic [24], and three both thyreotropic and corticotropic function deficits. All patients were treated with appropriate doses of glucocorticoid (cortisone acetate, 37.5–50 mg daily), somatotropic (recombinant human GH, 0.3–0.6 mg daily), and thyroid (levothyroxine, 75–100 μ g daily) replacement therapy, depending on the specific hormone deficit.…”

Section: Methodsmentioning

confidence: 99%

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Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism

Tirabassi

Muti

Corona

et al. 2013

International Journal of Endocrinology

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Aim. To evaluate the independent role of androgen receptor (AR) gene CAG repeat polymorphism on metabolic effects of testosterone replacement therapy (TRT) in male postsurgical hypogonadotropic hypogonadism, a condition frequently associated with hypopituitarism and in which the TRT-related metabolic effects are combined with those deriving from concomitant administration of metabolically active pituitary-function replacement therapies. Methods. 15 men affected by postsurgical hypogonadotropic hypogonadism were evaluated before and after TRT. Cardiovascular risk factors (CVRFs), pituitary-dependent hormones, and AR gene CAG repeat polymorphism were considered. Results. Testosterone, insulin-like growth factor 1 (IGF-1), and estradiol were the only hormones, which varied significantly between the two phases. All CVRFs significantly improved after TRT. The number of CAG triplets was positively and significantly correlated with all the variations (Δ-) of CVRFs (except for a significant negative correlation with Δ-high-density lipoprotein); the opposite occurred between the latter and Δ-testosterone. No correlation between Δ-IGF-1 or estradiol and Δ-CVRFs was found. At multiple linear regression, after correction for Δ-testosterone, nearly all the associations between the number of CAG triplets and Δ-CVRFs were confirmed. Conclusions. In male postsurgical hypogonadotropic hypogonadism, shorter AR gene CAG tract length seems to yield greater metabolic improvement after TRT, independently of the effects of concomitant pituitary-function replacement therapies.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism

Tirabassi

Muti

Corona

et al. 2013

International Journal of Endocrinology

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“…A retrospective study involving 44 PCa patients who received ADT showed an increase in fasting blood glucose, total cholesterol, LDL cholesterol, and TG, but a decrease in HDL cholesterol in these patients [ 34 ]. In addition, longitudinal studies indicate that lower T levels in men independently predict MetS [ 97 , 98 ] and type 2 diabetes mellitus (T2DM) [ 99 ]. Because MetS is independently associated with CV mortality [ 100 ], it is plausible that the positive association between lower serum T levels and MetS may at least in part explain the higher CV mortality in men with PCa receiving ADT (with therapy-induced hypogonadism as the likely trigger of these events) [ 101 ].…”

Section: Adverse Effects Of Adtmentioning

confidence: 99%

“…Because MetS is independently associated with CV mortality [ 100 ], it is plausible that the positive association between lower serum T levels and MetS may at least in part explain the higher CV mortality in men with PCa receiving ADT (with therapy-induced hypogonadism as the likely trigger of these events) [ 101 ]. The protective role of T on the CV system and its relationship to MetS, CV morbidity and mortality has been recently reviewed [ 98 ]. Since CV disease has become the most common cause of non-PCa-related death among this patient group [ 102 ], the potential risks of ADT with regards to CV events should be carefully weighed against the expected benefits.…”

Section: Adverse Effects Of Adtmentioning

confidence: 99%

The Use of Dietary Supplements to Alleviate Androgen Deprivation Therapy Side Effects during Prostate Cancer Treatment

et al. 2014

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Prostate cancer (PCa), the most commonly diagnosed cancer and second leading cause of male cancer death in Western societies, is typically androgen-dependent, a characteristic that underlies the rationale of androgen deprivation therapy (ADT). Approximately 90% of patients initially respond to ADT strategies, however many experience side effects including hot flashes, cardiotoxicity, metabolic and musculoskeletal alterations. This review summarizes pre-clinical and clinical studies investigating the ability of dietary supplements to alleviate adverse effects arising from ADT. In particular, we focus on herbal compounds, phytoestrogens, selenium (Se), fatty acids (FA), calcium, and Vitamins D and E. Indeed, there is some evidence that calcium and Vitamin D can prevent the development of osteoporosis during ADT. On the other hand, caution should be taken with the antioxidants Se and Vitamin E until the basis underlying their respective association with type 2 diabetes mellitus and PCa tumor development has been clarified. However, many other promising supplements have not yet been subjected large-scale clinical trials making it difficult to assess their efficacy. Given the demographic trend of increased PCa diagnoses and dependence on ADT as a major therapeutic strategy, further studies are required to objectively evaluate these supplements as adjuvant for PCa patients receiving ADT.

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Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study

Tirabassi

Sudano

Salvio

et al. 2018

International Journal of Endocrinology

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Background The effects of vitamin D on sexual function are very unclear. Therefore, we aimed at evaluating the possible association between vitamin D and sexual function and at assessing the influence of vitamin D administration on sexual function. Methods We retrospectively studied 114 men by evaluating clinical, biochemical, and sexual parameters. A subsample (n = 41) was also studied longitudinally before and after vitamin D replacement therapy. Results In the whole sample, after performing logistic regression models, higher levels of 25(OH) vitamin D were significantly associated with high values of total testosterone and of all the International Index of Erectile Function (IIEF) questionnaire parameters. On the other hand, higher levels of total testosterone were positively and significantly associated with high levels of erectile function and IIEF total score. After vitamin D replacement therapy, total and free testosterone increased and erectile function improved, whereas other sexual parameters did not change significantly. At logistic regression analysis, higher levels of vitamin D increase (Δ-) were significantly associated with high values of Δ-erectile function after adjustment for Δ-testosterone. Conclusions Vitamin D is important for the wellness of male sexual function, and vitamin D administration improves sexual function.

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An unusual syncope

Cited by 4 publications

References 8 publications

Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism

Androgen Receptor Gene CAG Repeat Polymorphism Regulates the Metabolic Effects of Testosterone Replacement Therapy in Male Postsurgical Hypogonadotropic Hypogonadism

The Use of Dietary Supplements to Alleviate Androgen Deprivation Therapy Side Effects during Prostate Cancer Treatment

Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study

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