An Unusual “Thyroid Cyst”: Intrathyroidal Parathyroid Cyst

Atwan, Manal; Chetty, Runjan

doi:10.1007/s12022-011-9158-7

Cited by 7 publications

(6 citation statements)

References 9 publications

(9 reference statements)

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“…14 Currently, there is no consensus on the management of ectopic intrathyroidal PCs as these are very rare cases often incidentally discovered following surgical intervention. 15 However, from our case and cases that were reported in the literature, percutaneous cyst aspiration would be a reasonable approach for uncomplicated nonfunctioning PCs. 8 Surgical excision remains the treatment of choice in functioning PCs or nonfunctioning cysts presenting with compressive symptoms or carcinomas.…”

Section: Discussionmentioning

confidence: 66%

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Intrathyroidal Parathyroid Cyst: An Unusual Neck Mass

Ahmad

Almohaya

Almalki

et al. 2017

Clin Med Insights Endocrinol Diabetes

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Parathyroid cyst (PC) is a very rare condition. A case of intrathyroidal PC is being reported here in a 53-year-old woman who presented to the endocrine clinic with slowly progressive painless left anterior neck swelling for 1 year with no symptoms of thyroid or parathyroid dysfunction and no compressive symptoms. Ultrasound of the thyroid showed a well-defined cystic lesion measuring 4.7 × 3.6 cm in maximum diameter with internal echoes within the cyst located in the left lobe of the thyroid gland. Fine needle aspiration revealed colorless clear fluid with a high concentration of parathyroid hormone. The patient underwent left hemithyroidectomy at her request. Histopathology revealed parathyroid tissue with unilocular cyst and thyroid tissue with goitrous changes. She was in remission, and there was no evidence of thyroid or parathyroid dysfunction after surgery.

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Section: Discussionmentioning

confidence: 66%

“…Currently, there is no consensus on the management of ectopic intrathyroidal PCs as these are very rare cases often incidentally discovered following surgical intervention. 15…”

Section: Discussionmentioning

confidence: 99%

Intrathyroidal Parathyroid Cyst: An Unusual Neck Mass

Ahmad

Almohaya

Almalki

et al. 2017

Clin Med Insights Endocrinol Diabetes

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“…In contrast, increased FNA-iPTH from an incidentally detected intrathyroid cyst, during USG evaluation of a multinodular goiter, lead to diagnosis of nonfunctional intrathyroidal parathyroid cyst in a 29-year-old asymptomatic female with papillary microcarcinoma of thyroid (4). Histopathological evaluation of left hemithyroidectomy, done for left-sided neck lump and simple thyroid cyst in a 19-year-old female, was diagnosed to be nonfunctional intrathyroidal parathyroid cyst (5). Pacini et al .…”

Section: Discussionmentioning

confidence: 99%

“…It is believed to be due to abnormal migration of parathyroid cells during embryogenesis. Ectopic superior parathyroids have been most commonly observed above intersection between recurrent laryngeal nerve and superior thyroid artery, followed by cricothyroid junction, posterior to upper pole of thyroid and rarely in retropharyngeal, retroesophageal, and intrathyroidal regions (5). In contrast, ectopic inferior parathyroids have been documented most commonly between lower pole of thyroid and thymus, followed by intra-thymus and in anterior mediastinum (5).…”

Section: Discussionmentioning

confidence: 99%

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Needle aspirate PTH in diagnosis of primary hyperparathyroidism due to intrathyroidal parathyroid cyst

Dutta¹,

Selvan²,

Kumar³

et al. 2013

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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SummaryParathyroid cysts are rare (0.8–3.41% of all parathyroid lesions) and usually arise secondary to cystic degeneration of parathyroid adenomas. Intrathyroidal parathyroid cysts are extremely rare with only three cases reported till date. We present a 24-year-old female with clinical and biochemical features of primary hyperparathyroidism (PHPT; Ca2 +: 12.1 mg/dl; intact parathyroid hormone (iPTH): 1283 pg/ml) and poor radiotracer uptake with minimal residual uptake in the left thyroid lobe at 2 and 4 h on Tc99m sestamibi imaging. Neck ultrasonography (USG) revealed 0.6×1 cm parathyroid posterior left lobe of thyroid along with 22×18 mm simple thyroid cyst. USG-guided fine-needle aspiration (FNA) and needle tip iPTH estimation (FNA-iPTH) from parathyroid lesion was inconclusive (114 pg/ml), necessitating FNA of thyroid cyst, which revealed high iPTH (3480 pg/ml) from the aspirate. The patient underwent a left hemithyroidectomy. A >50% drop in serum iPTH 20 min after left hemithyroidectomy (29.4 pg/ml) along with histopathology suggestive of intrathyroidal cystic parathyroid adenoma (cystic lesion lined by chief cell variant parathyroid cells without any nuclear atypia, capsular or vascular invasion surrounded by normal thyroid follicles) confirmed that the parathyroid cyst was responsible for PHPT. This report highlights the importance of FNA-iPTH in localizing and differentiating a functional parathyroid lesion from nonfunctional tissue in PHPT.Learning points Fine-needle aspiration from suspected parathyroid lesion and needle tip iPTH (FNA-iPTH) estimation from the saline washing has an important role in localizing primary hyperparathyroidism (PHPT).FNA-iPTH estimation may help in differentiating functional from nonfunctional parathyroid lesion responsible for PHPT.iPTH estimation from aspirate of an intrathyroid cyst is helpful in differentiating intrathyroidal parathyroid cyst from thyroid cyst.

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Swellings of the Tracheal Region

Sakr

2024

Midline Neck Swellings

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An Unusual “Thyroid Cyst”: Intrathyroidal Parathyroid Cyst

Cited by 7 publications

References 9 publications

Intrathyroidal Parathyroid Cyst: An Unusual Neck Mass

Intrathyroidal Parathyroid Cyst: An Unusual Neck Mass

Needle aspirate PTH in diagnosis of primary hyperparathyroidism due to intrathyroidal parathyroid cyst

Swellings of the Tracheal Region

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