An update on bacterial brain abscess in immunocompetent patients

Sonneville, Romain; Ruimy, Raymond; Benzonana, Nur; Riffaud, Laurent; Carsin, A.; Tadié, Jean‐Marc; Piau, Caroline; Revest, Matthieu; Tattevin, Pierre

doi:10.1016/j.cmi.2017.05.004

Cited by 138 publications

(144 citation statements)

References 37 publications

Supporting

Mentioning

109

Contrasting

Unclassified

Order By: Relevance

“…The barrier comprises microvascular endothelial cells, astrocytes and pericytes, and is tasked with the regulated passage of molecules into and out of the brain (Abbott et al, 2010;Sochocka et al, 2017b). Neurotropic bacteria are capable of evading host defenses, gaining access to the CNS (Dando et al, 2014), with >95% of brain abscesses caused by bacterial infection(s) (Sonneville et al, 2017). Furthermore, the brain may become particularly susceptible to bacterial infection(s), if the BBB is chronically compromised by an initial infection (Mendes et al, 1980;Cantiera et al, 2019).…”

Section: Main Findings Referencesmentioning

confidence: 99%

Overview of Brain-to-Gut Axis Exposed to Chronic CNS Bacterial Infection(s) and a Predictive Urinary Metabolic Profile of a Brain Infected by Mycobacterium tuberculosis

et al. 2020

View full text Add to dashboard Cite

Frontiers in Neuroscience | www.frontiersin.org April 2020 | Volume 14 | Article 296 Isaiah et al.CSF Metabolic Response to Mycobacterium effects expected, predicting pivotal altered metabolic pathways that would be reflected in the urinary profiles of TBM subjects. Our cascading metabolic model should be adjustable to account for other types of CNS bacterial infection(s) associated with chronic neuroinflammation, typically prevalent, and difficult to distinguish from TBM, in the resource-constrained settings of poor communities.

show abstract

Section: Main Findings Referencesmentioning

confidence: 99%

Overview of Brain-to-Gut Axis Exposed to Chronic CNS Bacterial Infection(s) and a Predictive Urinary Metabolic Profile of a Brain Infected by Mycobacterium tuberculosis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Timely initiation of empiric antibiotics has been associated with better clinical outcome [13]. For better diagnostic accuracy and antibiotic coverage, an empiric regimen should be started shortly after the aspiration of one abscess has been performed, and should be able to cover staphylococci, streptococci, strict anaerobes, and Enterobacteriaceae [14].…”

Section: Discussionmentioning

confidence: 99%

Multiple Listeria Abscesses in an Immunocompetent Patient

Frade

Pingili

Nattanamai

2020

Cureus

View full text Add to dashboard Cite

“…The medical therapy is based on prolonged systemic antibiotic administration [3]. In literature, different antibiotic combinations were reported, but in all cases, the duration of therapy was at least 4 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…Brain abscess is a focal infective process of cerebral parenchyma that can be caused by bacteria, mycobacteria, fungi, or parasites [1][2][3]. The incidence is variable according to the existence of predisposing conditions such as a primary infection focus, metastatic infection from a pulmonary focus, and heart disease [2].…”

Section: Introductionmentioning

confidence: 99%

Rare Pathogens of Central Nervous System: a Systematic Literature Review and Report of Two New Cases of Cerebral Abscesses Due to Gemella morbillorum

Vetrano

Caroli

Spagnoli

et al. 2019

SN Compr. Clin. Med.

View full text Add to dashboard Cite

To evaluate and characterize cases of brain abscess in immunocompetent patients due to Gemella morbillorum, an opportunistic Gram-positive coccus. Two cases of brain abscess due to this pathogen which occurred at the authors' native institution in 2013 and 2016 were analyzed. Moreover, a literature search regarding brain abscess surgically treated due to this pathogen was performed in PubMed database, following PRISMA statement. The final review comprised ten articles for a total of 11 patients-all immunocompetent-with a median age of 50.2 years (range 28-77); almost total were males. Neurological deficits and fever were the most common initial signs; seizures were present only in two cases. Surgical treatment was based on craniotomy and excision in six cases; the remaining five underwent stereotactic aspiration. The antibiotic initial therapy was intravenous in all cases. The average duration of therapy was of six weeks with a minimum of four and maximum of ten. One patient died, while in the other cases, a complete or partial regression of presenting symptoms and disappearing of MRI signs at intermediate follow-up were obtained. In eight patients (72%), it was possible to identify a primary infection or a predisposing factor (as cardiac diseases or septic arthritis). G. morbillorum is an emerging pathogen involved in brain abscesses. Even if it is infrequently reported, the identification of specific characteristics that may increase its neurotropism and virulence also in immunocompetent patients can help to better understand such a rare pathology.

show abstract

An update on bacterial brain abscess in immunocompetent patients

Abstract: Significant advances in brain imaging, minimally invasive neurosurgery, molecular biology and antibacterial agents have dramatically improved the prognosis of brain abscess in immunocompetent patients over the last decades.

Cited by 138 publications

References 37 publications

Overview of Brain-to-Gut Axis Exposed to Chronic CNS Bacterial Infection(s) and a Predictive Urinary Metabolic Profile of a Brain Infected by Mycobacterium tuberculosis

Overview of Brain-to-Gut Axis Exposed to Chronic CNS Bacterial Infection(s) and a Predictive Urinary Metabolic Profile of a Brain Infected by Mycobacterium tuberculosis

Multiple Listeria Abscesses in an Immunocompetent Patient

Rare Pathogens of Central Nervous System: a Systematic Literature Review and Report of Two New Cases of Cerebral Abscesses Due to Gemella morbillorum

Contact Info

Product

Resources

About