An Update on Diagnostic Laboratory Biomarkers for Multiple Sclerosis

Kaisey, Marwa; Lashgari, Ghazal; Fert-Bober, Justyna; Ontaneda, Daniel; Solomon, Andrew; Sicotte, Nancy L.

doi:10.1007/s11910-022-01227-1

Cited by 13 publications

(11 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also plays a role in cell mitosis, astrocyte-neuron communication and glial scar formation. The detection of GFAP in CSF or serum reflects the damage of astrocytes ( 24 , 25 ). There is a close correlation between CSF and serum GFAP (sGFAP) levels in patients with demyelinating diseases ( 26 , 27 ).…”

Section: Glial Fibrillary Acid Protein (Gfap)mentioning

confidence: 99%

See 1 more Smart Citation

Biomarkers in autoimmune diseases of the central nervous system

et al. 2023

View full text Add to dashboard Cite

The autoimmune diseases of the central nervous system (CNS) represent individual heterogeneity with different disease entities. Although clinical and imaging features make it possible to characterize larger patient cohorts, they may not provide sufficient evidence to detect disease activity and response to disease modifying drugs. Biomarkers are becoming a powerful tool due to their objectivity and easy access. Biomarkers may indicate various aspects of biological processes in healthy and/or pathological states, or as a response to drug therapy. According to the clinical features described, biomarkers are usually classified into predictive, diagnostic, monitoring and safety biomarkers. Some nerve injury markers, humoral markers, cytokines and immune cells in serum or cerebrospinal fluid have potential roles in disease severity and prognosis in autoimmune diseases occurring in the CNS, which provides a promising approach for clinicians to early intervention and prevention of future disability. Therefore, this review mainly summarizes the potential biomarkers indicated in autoimmune disorders of the CNS.

show abstract

Section: Glial Fibrillary Acid Protein (Gfap)mentioning

confidence: 99%

“…Recently, a large number of studies have investigated the potential of GFAP as an indicator of disability progression, diagnosis and early disease activity in MS ( 24 ). One study established a positive correlation between sGFAP and EDSS score or recent attacks, but no therapeutic effect was detected in RRMS.…”

Section: Glial Fibrillary Acid Protein (Gfap)mentioning

confidence: 99%

Biomarkers in autoimmune diseases of the central nervous system

et al. 2023

View full text Add to dashboard Cite

show abstract

“…317 Intravenous administration of MSC-EXOs recovered Theiler’s murine encephalomyelitis virus (TMEV)-induced demyelinating disease. 172 , 318 MSC-EXOs polarize microglia cells mainly into the M2 phenotype and consequently improve clinical scores of EAE. MSC-EXOs improved proliferation of oligodendroglia cell line (OLN93) through reduction of both inflammatory responses and demyelinated lesions in the CNS of EAE mice.…”

Section: Multiple Sclerosis (Ms)mentioning

confidence: 99%

Biogenesis, Composition and Potential Therapeutic Applications of Mesenchymal Stem Cells Derived Exosomes in Various Diseases

Yuan¹,

Wang²,

Zhang³

et al. 2023

IJN

View full text Add to dashboard Cite

Exosomes are nanovesicles with a wide range of chemical compositions used in many different applications. Mesenchymal stem cell-derived exosomes (MSCs-EXOs) are spherical vesicles that have been shown to mediate tissue regeneration in a variety of diseases, including neurological, autoimmune and inflammatory, cancer, ischemic heart disease, lung injury, and liver fibrosis. They can modulate the immune response by interacting with immune effector cells due to the presence of anti-inflammatory compounds and are involved in intercellular communication through various types of cargo. MSCs-EXOs exhibit cytokine storm-mitigating properties in response to COVID-19. This review discussed the potential function of MSCs-EXOs in a variety of diseases including neurological, notably epileptic encephalopathy and Parkinson’s disease, cancer, angiogenesis, autoimmune and inflammatory diseases. We provided an overview of exosome biogenesis and factors that regulate exosome biogenesis. Additionally, we highlight the functions and potential use of MSCs-EXOs in the treatment of the inflammatory disease COVID-19. Finally, we covered a strategies and challenges of MSCs-EXOs. Finally, we discuss conclusion and future perspectives of MSCs-EXOs.

show abstract

“…More prevalent in females, multiple sclerosis (MS) is a neurological inflammatory and degenerative disease with an increasing prevalence worldwide, with approximately three million people estimated to be affected [ 1 , 2 ]. Timely diagnosis of MS enables effective therapy and minimizes unpredictable dysfunction [ 3 ]. Efforts have been made to improve diagnostic criteria for MS recently [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…While the criteria are often misunderstood and inappropriately applied [ 6 ]. Therefore, recent researches have been attempted to explore novel diagnostic biomarkers to improve diagnosis, monitoring and treatment for MS [ 3 ]. Serum glial fibrillary acid protein readily distinguishes MS from healthy controls [ 7 ].…”

Section: Introductionmentioning

confidence: 99%