An update on liposomes in drug delivery: a patent review (2014-2018)

El-Hammadi, Mazen M.; Arias, José L.

doi:10.1080/13543776.2019.1679767

Cited by 87 publications

(39 citation statements)

References 39 publications

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“…In recent decades, many biomembrane-wrapped drug delivery systems have been rapidly developed. One strategy is to reconstitute the natural biosystems by mimicking their basic components, such as the well-known liposomes [29,30] and the reconstituted lipoproteins (e.g. reconstituted low/high-density lipoproteins) [20,31,32].…”

Section: Discussionmentioning

confidence: 99%

Isolated cell-bound membrane vesicles (CBMVs) as a novel class of drug nanocarriers

et al. 2020

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Background: Cell-bound membrane vesicles (CBMVs) are a type of membrane vesicles different from the wellknown extracellular vesicles (EVs). In recent years, the applications of EVs as drug delivery systems have been studied widely. A question may arise whether isolated CBMVs also have the possibility of being recruited as a drug delivery system or nanocarrier? Methods: To test the possibility, CBMVs were isolated/purified from the surfaces of cultured endothelial cells, loaded with a putative antitumor drug doxorubicin (Dox), and characterized. Subsequently, cellular experiments and animal experiments using mouse models were performed to determine the in vitro and in vivo antitumor effects of Doxloaded CBMVs (Dox-CBMVs or Dox@CBMVs), respectively. Results: Both Dox-free and Dox-loaded CBMVs were globular-shaped and nanometer-sized with an average diameter of ~ 300-400 nm. Dox-CBMVs could be internalized by cells and could kill multiple types of cancer cells. The in vivo antitumor ability of Dox-CBMVs also was confirmed. Moreover, Quantifications of blood cells (white blood cells and platelets) and specific enzymes (aspartate aminotransferase and creatine kinase isoenzymes) showed that Dox-CBMVs had lower side effects compared with free Dox. Conclusions: The data show that the CBMV-entrapped Doxorubicin has the antitumor efficacy with lower side effects. This study provides evidence supporting the possibility of isolated cell-bound membrane vesicles as a novel drug nanocarrier.

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Section: Discussionmentioning

confidence: 99%

Isolated cell-bound membrane vesicles (CBMVs) as a novel class of drug nanocarriers

et al. 2020

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“…An ideal drug delivery vehicle demands, targeted drug delivery of smaller doses to the target site in order to reduce toxicity and other unwanted side effects, biocompatibility, non-immunogenicity, and biodegradability. 195 To fulfill these demands, a lot of attempts have been done over the past few decades to develop some innovative drug delivery systems, such as liposomes, [196][197][198] micelles, 199,200 polymeric and synthetic nanoparticles, 201,202 extracellular vesicles, [203][204][205] dendrimers, 206,207 and so on. However, due to some of their limitations, the naturally occurring exosomes are gaining much attention in this aspect, thanks to their vital characteristic features.…”

Section: Exosome As a Potential Drug Delivery Vehicle To Bone Diseasesmentioning

confidence: 99%

Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma

Samal

Dash

2021

IJN

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The increasing incidence of bone-related disorders is causing a burden on the clinical scenario. Even though bone is one of the tissues that possess tremendous regenerative potential, certain bone anomalies need therapeutic intervention through appropriate delivery of a drug. Among several nanosystems and biologics that offer the potential to contribute towards bone healing, the exosomes from the class of extracellular vesicles are outstanding. Exosomes are extracellular nanovesicles that, apart from the various advantages, are standing out of the crowd for their ability to conduct cellular communication. The internal cargo of the exosomes is leading to its potential use in therapeutics. Exosomes are being unraveled in terms of the mechanism as well as application in targeting various diseases and tissues. Through this review, we have tried to understand and review all that is already established and the gap areas that still exist in utilizing them as drug delivery vehicles targeting the bone. The review highlights the potential of the exosomes towards their contribution to the drug delivery scenario in the bone microenvironment. A comparison of the pros and cons of exosomes with other prevalent drug delivery systems is also done. A section on the patents that have been generated so far from this field is included.

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“…Gold and silver nanoparticles are solid structures that can be associated with drugs, or can be functionalized themselves to perform a specific function: the nanoparticle itself is a drug. For the case of silica nanoparticles they can be porous and contain drugs and can even have complex multi-compartment structure, carrying many different drug molecules (Torchilin, 2007;Pattni et al, 2015;Bulbake et al, 2017;El-Hammadi and Arias, 2019;Bhardwaj et al, 2020;Crommelin et al, 2020), for example for applications like theragnostics (Janib et al, 2010). In the same fashion as solid inorganic nanoparticles, carbon architectures are contiguous solid structures, however, due to its unique chemistry, composition from carbon allows for a wide variety of forms, including carbon dots (Peng et al, 2017;Ghosal and Ghosh, 2019), nanotubes (Sun et al, 2014), nanodiamonds (Barnard, 2016;Ge and Wang, 2017), nanographene (Zhang L. et al, 2013;Sun et al, 2014;Sgarlata et al, 2016;Ghadari and Kashefi, 2017;Hasanzade and Raissi, 2017;Moradi et al, 2018;Alinejad et al, 2020;Mahdavi et al, 2020), and graphene oxide (Duverger and Picaud, 2020;Shahabi and Raissi, 2020).…”

Section: Nanomedicinementioning

confidence: 99%

Mechanistic Understanding From Molecular Dynamics Simulation in Pharmaceutical Research 1: Drug Delivery

Bunker

Róg

2020

Front. Mol. Biosci.

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In this review, we outline the growing role that molecular dynamics simulation is able to play as a design tool in drug delivery. We cover both the pharmaceutical and computational backgrounds, in a pedagogical fashion, as this review is designed to be equally accessible to pharmaceutical researchers interested in what this new computational tool is capable of and experts in molecular modeling who wish to pursue pharmaceutical applications as a context for their research. The field has become too broad for us to concisely describe all work that has been carried out; many comprehensive reviews on subtopics of this area are cited. We discuss the insight molecular dynamics modeling has provided in dissolution and solubility, however, the majority of the discussion is focused on nanomedicine: the development of nanoscale drug delivery vehicles. Here we focus on three areas where molecular dynamics modeling has had a particularly strong impact: (1) behavior in the bloodstream and protective polymer corona, (2) Drug loading and controlled release, and (3) Nanoparticle interaction with both model and biological membranes. We conclude with some thoughts on the role that molecular dynamics simulation can grow to play in the development of new drug delivery systems.

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An update on liposomes in drug delivery: a patent review (2014-2018)

Cited by 87 publications

References 39 publications

Isolated cell-bound membrane vesicles (CBMVs) as a novel class of drug nanocarriers

Isolated cell-bound membrane vesicles (CBMVs) as a novel class of drug nanocarriers

Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma

Mechanistic Understanding From Molecular Dynamics Simulation in Pharmaceutical Research 1: Drug Delivery

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