2021
DOI: 10.5644/ama2006-124.333
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An Update on Molecular Genetic Aberrations in Spitz Melanocytic Proliferations: Correlation with Morphological Features and Biological Behavior

Abstract: <p>The aim of the paper is to give an update on molecular genetic aberrations in Spitz melanocytic proliferations with special em- phasis on their correlation with morphological features and biological behavior. The Spitz group of melanocytic proliferations is defined by a combination of distinctive morphological features and driver molecular genetic events. Morphologically, these neoplasms are characterized by large, oval, polygonal, or spindled melanocytes with abundant eosinophilic cytoplasm, vesicula… Show more

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Cited by 9 publications
(12 citation statements)
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“…Whenever histopathology is insufficient to make the final diagnosis, ancillary methods are utilized, such as immunohistochemical staining, fluorescence in situ hybridization (FISH), or molecular genetic analysis (1,13).…”
Section: Ancillary Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Whenever histopathology is insufficient to make the final diagnosis, ancillary methods are utilized, such as immunohistochemical staining, fluorescence in situ hybridization (FISH), or molecular genetic analysis (1,13).…”
Section: Ancillary Methodsmentioning
confidence: 99%
“…The hallmark of Spitz melanocytic proliferation upon histological examination is the presence of epithelioid and/or spindled melanocytes with abundant eosinophilic cytoplasm and frequently associated hyperplasia of the epidermis (13). Atypical Spitz tumors show histopathological characteristics of Spitz nevi and melanomas.…”
Section: Histopathologic Featuresmentioning
confidence: 99%
“…Kamino bodies are variable, and approximately 25% of cases will have a degree of pagetoid spread [29]. Both Pan-trk and NTRK1 are reliable and cost-effective but non-specific methods for screening for NTRK fusion [23,[27][28][29][30].…”
Section: Ntrk1-rearranged Spitz Tumorsmentioning
confidence: 99%
“…In addition, rare BRAF gene fusions have been described in various cancer subtypes (frequency 0.3%), particularly in Spitzoid melanomas, pilocytic astrocytomas, papillary thyroid carcinomas, acinar pancreatic carcinomas, gastric carcinomas, serous ovarian carcinomas (both low-and highgrade), salivary gland carcinomas, and histiocytic neoplasms (pediatric and adult xanthogranulomas) (64)(65)(66)(67)(68)(69)(70)(71)(72)(73). BRAF gene fusions and point mutations have recently been found in a subset of adult and pediatric soft tissue tumors with spindle cell morphology and infantile fibrosarcoma-like growth pattern (74)(75)(76).…”
Section: Braf Mutations and Other Genomic Alterationsmentioning
confidence: 99%