An Update on Spinal Dural Arteriovenous Fistulae: Case Series and Systematic Review

Abstract

Spinal dural arteriovenous fistulae (sDAVFs) are rare entities with delayed diagnosis, potentially dramatic clinical manifestations, and complex management. We aim to present our mini case series and perform an updated systematic review of the usual patient profile, to search for established prognostic factors, to compare the effectiveness and safety of surgical and endovascular intervention, and to discuss trends in therapeutic strategy. We retrospectively collected data from patients treated in our department in the last decade (2014-2024) and we systematically reviewed the literature according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria and searched the PubMed database for relevant articles published in the same period. Epidemiologic data, imaging modalities, prognostic factors, and treatment modalities were assessed. Firstly, we identified four illustrative cases from our institution. In addition, our search yielded 559 studies and our review included 82 original studies. 3130 patients were identified (mean age 61; male-to-female ratio 3:1). Most commonly, the fistula level was in the thoracic spine (65%). Surgery was provided to 1837 patients (1213 as primary treatment) and embolism to 1085 (932 as primary treatment). Initial fistula occlusion rate and recurrence rate were 98.1% and 1.9% for surgery and 71.1% and 9.6% for embolism, respectively. No difference between the two modalities with respect to clinical outcome was observed. SDAVFs remain a challenge for neurosurgeons concerning both diagnosis and management. Surgery remains superior to embolism with respect to success as an initial treatment. Embolism can be offered if certain contraindications do not coexist. All symptomatic patients should be offered treatment, whereas asymptomatic patients could be conservatively managed only if the close patient follow-up can be secured.