An Update on the Efficacy and Functionality of Probiotics for the Treatment of Non-Alcoholic Fatty Liver Disease

Yao, Mingfei; Qv, Lingling; Lu, Yao; Wang, Baohong; Berglund, Björn; Li, Lanjuan

doi:10.1016/j.eng.2020.01.017

Cited by 27 publications

(22 citation statements)

References 101 publications

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“…In this regard, besides the more “conventional” probiotics such as Bifidobacterium and Lactobacillus , much attention has also been paid to other microorganisms referred to as next-generation probiotics (NGP) as potential therapeutic approaches for NAFLD management. These “new” probiotics, resulting from improved culture methods, bioinformatics and next-generation sequencing, include such species as Akkermansia muciniphila , Faecalibacterium prausnitzii , Eubacterium hallii , Propionibacterium , Bacteroides fragilis and genus belonging to the Clostridia clusters IV, XIVa and XVIII [ 69 ]. For instance, lower Akkermansia muciniphila abundances have been related to metabolic disorders such as obesity and NAFLD [ 70 , 71 ].…”

Section: Limitations Of Probiotic Administration and Potential Altern...mentioning

confidence: 99%

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Usefulness of Probiotics in the Management of NAFLD: Evidence and Involved Mechanisms of Action from Preclinical and Human Models

Arellano-García

Baquedano

Martínez

et al. 2022

IJMS

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The present review aims at analyzing the current evidence regarding probiotic administration for non-alcoholic fatty liver disease (NAFLD) management. Additionally, the involved mechanisms of action modulated by probiotic administration, as well as the eventual limitations of this therapeutic approach and potential alternatives, are discussed. Preclinical studies have demonstrated that the administration of single-strain probiotics and probiotic mixtures effectively prevents diet-induced NAFLD. In both cases, the magnitude of the described effects, as well as the involved mechanisms of action, are comparable, including reduced liver lipid accumulation (due to lipogenesis downregulation and fatty acid oxidation upregulation), recovery of gut microbiota composition and enhanced intestinal integrity. Similar results have also been reported in clinical trials, where the administration of probiotics proved to be effective in the treatment of NAFLD in patients featuring this liver condition. In this case, information regarding the mechanisms of action underlying probiotics-mediated hepatoprotective effects is scarcer (mainly due to the difficulty of liver sample collection). Since probiotics administration represents an increased risk of infection in vulnerable subjects, much attention has been paid to parabiotics and postbiotics, which seem to be effective in the management of several metabolic diseases, and thus represent a suitable alternative to probiotic usage.

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Section: Limitations Of Probiotic Administration and Potential Altern...mentioning

confidence: 99%

“…In addition, it was reported that in NAFLD patients, the abundance of Faecalibacterium prausnitzii tends to be low. Since this bacteria is known to produce butyrate, its usefulness for NAFLD prevention was proposed [ 69 ]. Similarly, Roseburia spp.…”

Section: Limitations Of Probiotic Administration and Potential Altern...mentioning

confidence: 99%

Usefulness of Probiotics in the Management of NAFLD: Evidence and Involved Mechanisms of Action from Preclinical and Human Models

Arellano-García

Baquedano

Martínez

et al. 2022

IJMS

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“…As previously mentioned, the GM plays a dominant role in the pathogenesis of NAFLD [ 155 ]. Changes in its composition (for instance, an increase in Gram-negative bacteria belonging to Proteobacteria , Escherichia , and Enterobacteria species) increase intestinal permeability, resulting in the translocation of endotoxins and toxic metabolites into the liver, and leading to the production of inflammatory cytokines by Kupffer cells [ 156 , 157 , 158 ].…”

Section: Probioticsmentioning

confidence: 99%

Age-Related NAFLD: The Use of Probiotics as a Supportive Therapeutic Intervention

Campagnoli

Marchesi

Vairetti

et al. 2022

Cells

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Human aging, a natural process characterized by structural and physiological changes, leads to alterations of homeostatic mechanisms, decline of biological functions, and subsequently, the organism becomes vulnerable to external stress or damage. In fact, the elderly population is prone to develop diseases due to deterioration of physiological and biological systems. With aging, the production of reactive oxygen species (ROS) increases, and this causes lipid, protein, and DNA damage, leading to cellular dysfunction and altered cellular processes. Indeed, oxidative stress plays a key role in the pathogenesis of several chronic disorders, including hepatic diseases, such as non-alcoholic fatty liver disease (NAFLD). NAFLD, the most common liver disorder in the Western world, is characterized by intrahepatic lipid accumulation; is highly prevalent in the aging population; and is closely associated with obesity, insulin resistance, hypertension, and dyslipidemia. Among the risk factors involved in the pathogenesis of NAFLD, the dysbiotic gut microbiota plays an essential role, leading to low-grade chronic inflammation, oxidative stress, and production of various toxic metabolites. The intestinal microbiota is a dynamic ecosystem of microbes involved in the maintenance of physiological homeostasis; the alteration of its composition and function, during aging, is implicated in different liver diseases. Therefore, gut microbiota restoration might be a complementary approach for treating NAFLD. The administration of probiotics, which can relieve oxidative stress and elicit several anti-aging properties, could be a strategy to modify the composition and restore a healthy gut microbiota. Indeed, probiotics could represent a valid supplement to prevent and/or help treating some diseases, such as NAFLD, thus improving the already available pharmacological intervention. Moreover, in aging, intervention of prebiotics and fecal microbiota transplantation, as well as probiotics, will provide novel therapeutic approaches. However, the relevant research is limited, and several scientific research works need to be done in the near future to confirm their efficacy.

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“…Furthermore, increasing the abundance of P. copri in the guts of pregnant mothers may help prevent food allergies in children [7]. Oral probiotics have many benefits for human health [8][9][10][11]. Some probiotics or mixed probiotics can be used to interfere with the microbiota of mothers, which may have beneficial effects on the offspring.…”

Section: Introductionmentioning

confidence: 99%

A. muciniphila Supplementation in Mice during Pregnancy and Lactation Affects the Maternal Intestinal Microenvironment

Tian

et al. 2022

Nutrients

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During pregnancy and lactation, considerable factors that affect the maternal microbiome are associated with the advancement of numerous diseases, which can potentially affect offspring health. Probiotics have shown potential for the maintenance of microbiota homeostasis of mothers in this period. The specific objective of this study was to investigate whether the application of Akkermansia muciniphila (A. muciniphila) during pregnancy and lactation impacts maternal and offspring health. Here we show that dams fed with A. muciniphila is safe, enhances the intestinal barrier and alters gut microbiota composition and diversity at the end of lactation, including the significant enrichment of A. muciniphila and Ruminococcus_1 in offspring from probiotic-fed dams. However, compared with the control group, the fecal metabolites of the A. muciniphila group only changed slightly. Additionally, A. muciniphila supplementation did not significantly increase the abundance of A. muciniphila in the fecal microbiota of offspring mice. Compared with the control group, the fecal metabolic profile of three-week-old offspring of mice fed with A. muciniphila were significantly changed, containing the D-glutamine and D-glutamate metabolism pathways. These results provided evidence that A. muciniphila supplementation in mice during pregnancy and lactation is safe and seemed to have a more beneficial effect on dams. In the future, using probiotics to regulate maternal microbiomes during pregnancy and lactation could be shown to have a more lasting and beneficial effect.

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An Update on the Efficacy and Functionality of Probiotics for the Treatment of Non-Alcoholic Fatty Liver Disease

Cited by 27 publications

References 101 publications

Usefulness of Probiotics in the Management of NAFLD: Evidence and Involved Mechanisms of Action from Preclinical and Human Models

Usefulness of Probiotics in the Management of NAFLD: Evidence and Involved Mechanisms of Action from Preclinical and Human Models

Age-Related NAFLD: The Use of Probiotics as a Supportive Therapeutic Intervention

A. muciniphila Supplementation in Mice during Pregnancy and Lactation Affects the Maternal Intestinal Microenvironment

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