An Update on the Management of Uterine Carcinosarcoma

Abstract

After completing this CME activity, physicians should be better able to appraise the aggressive nature of uterine carcinosarcoma and factors which would help in delaying or preventing recurrence, assess the importance of lymphadenectomy for uterine carcinosarcoma and its effect on survival, and evaluate various recent trials addressing the chemo-radiotherapeutic combinations as adjuvant therapy.

Improved survival related to changes in endometrial cancer treatment, a 30-year population based perspective

“…2 The Hordaland cohort collected during our study thus is assumed to be representative of a general Norwegian endometrial cancer population. During later years these tumours have increasingly been treated and classified as endometrial carcinomas 171 , in line with national guidelines. 40 Identification of cases and registration of clinical data was otherwise similar for the Haukeland University Hospital and the Hordaland Cohorts.…”

Role of p53 Pathway Alterations in Uterine Carcinosarcomas (Malignant Mixed Müllerian Tumors)

“…The sarcomatous component may be homologous (endometrial stromal sarcoma, fibrosarcoma or leiomyosarcoma) or heterologous (rhabdomyosarcoma, chondrosarcoma, osteosarcoma or liposarcoma) [1,2,3]. The patients' overall survival is still unsatisfactory due to the high rate of distant recurrences [2,4,5,6,7,8,9]. In general, the overall 5-year survival for all clinical stages of uterine CSs is nearly 30%, increasing to 50% for tumors confirmed only to the uterus [4,6,10,11].…”

“…Histologically, both tumor components - epithelial and mesenchymal - are malignant, and they are characterized by an extremely aggressive course leading to an unfavorable prognosis [1,4,5,6]. Uterine CSs are classified as homologous or heterologous tumors, based on the types of sarcomatous differentiation [1,2,3,7].…”

Integratives Management unter Einsatz von Ayurveda-Medizin bei einer Patientin mit fortgeschrittenem Malignen Müllerschen Mischtumor - ein Fallbericht

“…Dabei steht aufgrund des üblichen Verlaufs und der schlechten Prognose bei solch fortgeschrittenen Stadien einer Tumorerkrankung der Erhalt der Lebensqualität im Zentrum des therapeutischen Bemühens [9,10,11,12]. Hierfür erscheint das in Südasien tradierte «Whole Medical System» Ayurveda besonders geeignet.…”