An Update on the Recent Emergence of Candida auris

Jain, Monika; Jain, Anushree; Khare, Basant; Jain, Deepak Kumar; Khan, Rubeena; Jain, Dolly

doi:10.22270/ajdhs.v2i1.11

Cited by 7 publications

(8 citation statements)

References 36 publications

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“…Bestatin possesses antitumor activity and also increase the antitumor activity of bleomycin and adriamycin. Bestatin efficiently prevented the metastasis of P388 leukemia when the antibiotic was constantly injected after tumor inoculation 23 . The dipeptide was immunorestorator in the elderly and cancer patients and HIVinfected subjects.…”

Section: Immunostimulatory Drugsmentioning

confidence: 99%

Immunostimulants: Concepts, Types and Functions

Jain

Darji²,

Thakur³

et al. 2022

Asian J Dental Health Sci

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The proper functioning of human immune system is essential for organism survival against infectious, toxic and oncogenic agents. The concept of immunomodulation was proposed by Edward Jenner, while working on polio vaccine in 1796. A brawny, fine-functioning immune system is the keystone of excellent health. Immune replies are the consequence of an effectual interaction among innate (natural and non-specific) and acquired (adaptive and specific) components of the immune system. Inequity or failure of the immune systems is connected with a variety of chronic illness counting allergies, autoimmune diseases, cancers and furthers. Immunomodulators are natural or synthetic materials that regulate the immune system and induce innate and adaptive defense mechanisms. These substances are classified into two types, immunostimulants and immunosuppressants. Immunostimulants can enhance body's resistance against various infections through increasing the basal levels of immune response. These agents could increase the oxidative activity of neutrophils, augment engulfment activity of phagocytic cells and stimulate cytotoxic cells as necessary defense mechanisms. The researchers classified the immunostimulants using their origin and mode of action such as bacterial products, complex carbohydrates, vaccines (antigens and adjuvants), cytokines, immunoenhancing drugs, nutritional factors, animal extracts, and plant extracts. The link between immune system with diet, exercise, sleep, stress, microbial exposure, alcohol, water, hygiene are found to influence the immune response to a greater extent. Immunostimulants and some immunity enhancing nutrients improve the functioning of the immune system. In addition, some preventive measures such as healthy diet or proper nutrition, moderate exercise, sound sleep, drinking adequate water, subclinical exposure to microbes and managing stress, good hygiene, are altogether capable of boosting the immune system. In this review, the concepts, types and functions of immunostimulants will be described as a therapeutic approach against different diseases. Keywords: Immunomodulators, Immunostimulants, Adjuvant, Mechanism, Immune system.

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Section: Immunostimulatory Drugsmentioning

confidence: 99%

Immunostimulants: Concepts, Types and Functions

Jain

Darji²,

Thakur³

et al. 2022

Asian J Dental Health Sci

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“…Psoriasis is a common autoimmune inflammatory skin disease that affects approximately 2-3% of the US population and over 125 million patients globally [26][27][28] . It is distinguished by T-cellmediated keratinocyte hyperproliferation and inflammatory processes that are based on a complex genetic background 26,27 .…”

Section: Beta Blocker Induced Psoriasismentioning

confidence: 99%

Review on Toxicity of Antihypertensive Drugs

Rajak

Sahu

Jain

et al. 2022

Asian J Dental Health Sci

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Adverse drug reactions are common and pose a serious health problem, limiting treatment options, causing compliance issues, and even leading to therapy discontinuation. Hypertension is a chronic disease that is regarded as a major risk factor for cardiovascular disease. To achieve a target blood pressure in an individual patient, a wide range of anti-hypertensive agents are available as single or combination therapy, whereas combination therapy increases the risk of developing Adverse Drug Reaction. Hypertensive patients frequently have coexisting disease conditions such as hyperlipidemia, impaired glucose metabolism, and renal impairment, which increase the risk of Cardio Vascular morbidity and mortality. When treating hypertensive patients, comprehensive management of both hypertension and concomitant Cardio Vascular Disease risk factors is essential. Some of the rare and serious Adverse Drug Reactions that occurred in patients treated with these drugs included beta-blockers causing psoriasis, calcium channel blockers causing gingival hyperplasia, peripheral oedema, Angiotensin Converting Enzyme inhibitors causing ankle oedema, and thiazide diuretics causing hyponatremia and hyperglycemia. Asymptomatic hypertension is more common and necessitates lifelong treatment with antihypertensive agents, predisposing to Adverse Drug Events.In order to improve treatment outcomes and reduce morbidity and mortality associated with adverse drug reactions, healthcare professionals must monitor adverse drug reactions in patients taking antihypertensive drugs. Keywords: Adverse drug reactions, Hypertension, hyperlipidemia, glucose metabolism

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“…Mayer et al 2013 30 lists 23 antibacterial compounds in preclinical pharmacological research. An interesting example is Anthracimycin, a polyketide antibiotic discovered in 2013, derived from marine actinobacteria that has shown significant activity against Bacillus anthracis, the bacteria that causes anthrax [31][32][33] .…”

Section: Antibacterialsmentioning

confidence: 99%

Novel Bioactive Compounds from Marine Sources as a Tool for Drug Development

Sahu

Kachhi

Thakur

et al. 2022

Int J Med Sci Pharm Res

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The marine environment is a relatively unexplored source of functional ingredients that can be used in food processing, storage, and fortification in a variety of ways. Marine microorganisms are a possible source of novel bioactive chemicals with potential human utility. Some of these microbes can live in the harsh marine environments, resulting in complex compounds with unique biological properties that can be used in several industrial and biotechnological applications. So far, several marine microorganisms (fungi, myxomycetes, bacteria, and microalgae) have been isolated that produce antioxidant, antibacterial, apoptotic, antitumoral, and antiviral chemicals. Furthermore, it emphasizes the enormous potential for marine microbes to produce very important bioactive chemicals. They are used for new drug developments extensively across the world. Marine pharmacology offers the scope for research on these drugs of marine origin. Few institutes in India offer such opportunities which can help us in the quest for new drugs. This is an extensive review of the drugs developed and the potential new drug candidates from marine origin along with the opportunities for research on marine derived products. It also gives the information about the institutes in India which offer marine pharmacology related courses. Keywords: Anticancer, Bryostatin, Cytarabine, Keyhole limpet hemocyanin, Mariculture, Sponge, Ziconotide

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An Update on the Recent Emergence of Candida auris

Cited by 7 publications

References 36 publications

Immunostimulants: Concepts, Types and Functions

Immunostimulants: Concepts, Types and Functions

Review on Toxicity of Antihypertensive Drugs

Novel Bioactive Compounds from Marine Sources as a Tool for Drug Development

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