An Updated Inventory on Properties, Pathophysiology and Therapeutic Potential of Snake Venom Thrombin-Like Proteases

A proteomic analysis of Pakistan Daboia russelii russelii venom and assessment of potency of Indian polyvalent and monovalent antivenom

“…S1) reported from Pakistan RVV [9]. Some of the SVSPs demonstrate fibrinogen clotting activity and they are termed "snake venom thrombin-like enzymes" (SVTLEs) [9,31,45]. Another class of SVSPs is similar to mammalian kallikrein and cleaves kininogen, thereby releasing bradykinin; these SVSPs are known as "kallikrein-like proteases" [49,50].…”

“…Snake venom proteases have been broadly classified into two catalytic types -SVSPs and SVMPs [40,41]. RVV is rich in both SVSPs and SVMPs, and they affect the hemostatic system in victims by proteolytic cleavage of several different blood coagulation factors [31,42,43]; thrombin-like activity is prominent [9,44,45]. In in vitro conditions, crude RVV displays procoagulant activity owing to the predominance of pro-coagulant proteases [2].…”