An Updated Meta-analysis on the Association of X-Ray Repair Cross Complementing Group 1 Codon 399 Polymorphism with Hepatocellular Carcinoma Risk

Wang, Yadong; Zhai, Wenlong; Wang, Hai‐Yu; Xia, Xiang-Qun

doi:10.7314/apjcp.2014.15.11.4443

Cited by 8 publications

(4 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetic variations in different individuals may alter the function of cytokine proteins, influencing the risk (Cheng et al, 2013;Liu et al, 2014;Wang et al, 2014;Zhang et al, 2014) and clinical outcomes of HCC (Pan et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study

Jeng

Wu²,

Tsai³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study

Jeng

Wu²,

Tsai³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Since this is preliminary report, our study is affected by the following limitations: (a) although there are 3 common single-nucleotide polymorphism (SNP) sites in the XRCC1 gene, and haplotype analyses could increase the power of the statistical analysis, a careful review of the literature leads us to analyze only the XRCC1 Arg399Gln polymorphism (14,(45)(46)(47)(48); (b) despite the fact that our analysis has shown no significant correlation between the XRCC1 Arg399Gln polymorphism and susceptibility to HCC in HCV-positive patients, as confirmed in previous studies (14), further analysis are needed to evaluate if HCV-positive status could be a significant variable in HCC patients…”

Section: Discussionmentioning

confidence: 99%

XRCC1 Arg399Gln Gene Polymorphism and Hepatocellular Carcinoma Risk in the Italian Population

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Current XRCC1 polymorphism studies mainly focus on 3 nonsynonymous mutant SNPs, namely Arg194Trp (rs1799782), Arg280His (rs25489), Arg399Gln (rs25487). The relationship between XRCC1 polymorphism and susceptibility to malignant tumors (such as nasopharyngeal cancer, breast cancer, lung cancer, stomach cancer, liver cancer, pancreatic cancer, colorectal cancer, prostate cancer, glioma, etc) has been reported many times [9–15] . Among the 3 non-synonymous mutated SNPs, Arg399Gln, and Arg194Trp were most correlated with cervical cancer susceptibility, but the conclusions were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

“…The relationship between XRCC1 polymorphism and susceptibility to malignant tumors (such as nasopharyngeal cancer, breast cancer, lung cancer, stomach cancer, liver cancer, pancreatic cancer, colorectal cancer, prostate cancer, glioma, etc) has been reported many times. [9][10][11][12][13][14][15] Among the 3 nonsynonymous mutated SNPs, Arg399Gln, and Arg194Trp were most correlated with cervical cancer susceptibility, but the conclusions were inconsistent. Therefore, this study used metaanalysis method to explore the relationship between XRCC1 Arg399Gln, Arg194Trp, Arg280His and susceptibility to 3 common female reproductive system tumors.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of XRCC1 single nucleotide polymorphism and susceptibility to gynecological malignancies

Zhang

2021

Medicine

View full text Add to dashboard Cite

Background: Gynecological malignant tumor is a serious threat to women's health, cervical cancer, endometrial cancer and ovarian cancer are the most common. The eponymous protein encoded by the XRCC1 (X-ray repair cross complementation 1) gene is an important functional protein in the process of single-stranded DNA damage. Non-synonymous mutations of XRCC1 gene cause amino acid sequence changes that affect protein function and DNA repair ability, and may affect the interaction with other DNA repair proteins, leading to increased risk of tumor development. Many studies have assessed the association between XRCC1 gene polymorphism and the risk of cancer in the female reproductive system, but the results have been inconclusive. In this study, the relationship between XRCC1 Arg399Gln, Arg194Trp, Arg280His single nucleotide polymorphisms and susceptibility to gynecological malignancies was further explored by meta-analysis. Methods: English database: Pubmed, Medline, Excerpta Medica Database, Cochrance, etc; Chinese database: China national knowledge infrastructure, Wanfang Database, etc. STATA14 was used for statistical analysis, such as odd ratio (OR) value, subgroup analysis, heterogeneity test, sensitivity analysis, and publication bias. Results: In gynecologic cancers, the allele frequency difference of Arg399Gln case control group was statistically significant (GvsA: P = .007). There was no significant difference in allele frequency in the Arg194Trp and Arg280His case control groups ( P = .065, 0.198). In different gene models, Arg399Gln was significantly correlated with gynecologic cancers susceptibility (GGvs AA: OR 0.91; 95% confidence interval [CI], 0.85 0.98); Arg194Trp was significantly correlated with gynecologic cancers susceptibility (CCvs TT: OR 0.94; 95% CI 0.88,1.00; CCvs CT: OR 0.97; 95% CI 0.90, 1.05); Arg280His was significantly correlated with gynecologic cancers susceptibility (GGvs AA: OR 0.98; 95% CI 0.94, 1.02; GGvs GA: OR 1.00;95% CI 0.97, 1.04). In the subgroup analysis, Arg399Gln and Arg194Trp were significantly correlated with gynecologic cancers susceptibility in the Asian race ( P = .000, 0.049). In the analysis of different cancer subgroups, Arg399Gln and cervical cancer susceptibility were statistically significant ( P = .039). Arg194Trp and endometrial cancer susceptibility were statistically significant ( P = .033, 0.001). Conclusions: XRCC1 Arg399Gln, Arg194Trp, Arg280His single nucleotide polymorphisms were associated with gynecologic cancer susceptibility. Arg399Gln genotype was statistically significant in relation to cervical cancer susceptibility. Arg194Trp genotype was statistically significant in relation to endometrial cancer susceptibility.

show abstract

An Updated Meta-analysis on the Association of X-Ray Repair Cross Complementing Group 1 Codon 399 Polymorphism with Hepatocellular Carcinoma Risk

Cited by 8 publications

References 34 publications

Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study

Independent and Additive Interaction Between Tumor Necrosis Factor β +252 Polymorphisms and Chronic Hepatitis B and C Virus Infection on Risk and Prognosis of Hepatocellular Carcinoma: a Case-Control Study

XRCC1 Arg399Gln Gene Polymorphism and Hepatocellular Carcinoma Risk in the Italian Population

A meta-analysis of XRCC1 single nucleotide polymorphism and susceptibility to gynecological malignancies

Contact Info

Product

Resources

About