An updated narrative review on the management of the most common oncological and hematological emergencies

Issani, Ali

doi:10.1016/j.disamonth.2022.101355

Cited by 6 publications

(5 citation statements)

References 55 publications

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“…X² refers to chi square test,** refers to highly significance if p value is less than 0.001. (Issani, 2022). Oncology nurses play an important role in the identification, prevention, and management of the chemotherapy extravasation (Atay, Üzen Cura, & Efil, 2021).…”

Section: Resultsmentioning

confidence: 99%

“…Variable r P Nurses' knowledge & practice (Pretest) 0.375 0.004* Nurses' knowledge & practice (Posttest) 0.332 0.012* r=refers to Pearson correlation, * refers to significance if p value is less than 0.001 5.Discussion:Chemotherapy extravasation refers to the inadvertent leakage of chemotherapy into the subcutaneous tissue during administration. It results in local reactions ranging from local irritation, swelling, erythema, burning, and pain at injected site to severe tissue destruction and necrosis(Issani, 2022). Oncology nurses play an important role in the identification, prevention, and management of the chemotherapy extravasation(Atay, Üzen Cura, & Efil, 2021).…”

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confidence: 99%

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Enhancement of Oncology Nurses' Competency Regarding Management of Intravenous Chemotherapy Extravasation

Elsayed,

Badran,

El Zaafarany

et al. 2024

Mansoura Nursing Journal

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Background: Chemotherapy extravasation is serious problem, causing a damage that may range from a minor skin reaction to full-thickness burn , muscle , tendon necrosis and results in extending hospital stays, increasing morbidity, and treatment costs. Aim: Enhance oncology nurses' competency regarding management of intravenous chemotherapy extravasation. Method: A quasi-experimental design one-group pretest posttest was used with a sample of 63 nurses working at the medical department and chemotherapy installation unit at Oncology Center at Mansoura University Hospital. Tools: Two tools were used: Tool 1: Structured Interview questionnaire . Tool 2: Nurses' practice observational checklist. Results: Nurses' knowledge levels improved regarding chemotherapy extravasation post educational intervention (80.7%) compared to (7%) pre educational intervention(P value <0.001*). Nurses' practice levels improved post educational intervention(86%) compared to (50.9%) pre educational intervention(P value <0.001*). Conclusion: There was statistically significant improvement in nurses' competency regarding chemotherapy extravasation post educational intervention. Recommendation: Continuous in-service training programs for oncology nurses regarding prevention and management of intravenous chemotherapy extravasation to improve their knowledge and practice.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Enhancement of Oncology Nurses' Competency Regarding Management of Intravenous Chemotherapy Extravasation

Elsayed,

Badran,

El Zaafarany

et al. 2024

Mansoura Nursing Journal

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“…have been continued until ANC recovery. 25 A randomized controlled trial suggested that antibiotics can safely be discontinued before the ANC recovers if the patient is stable, afebrile for 72 hours, and an infectious source has not been identified. 26 More research on this guideline is forthcoming.…”

Section: Cmementioning

confidence: 99%

“…This drug can be considered for off-label use in patients with known or suspected colonization with resistant organisms, previous hospitalizations, or antibiotic overuse 24. Historically, antibiotics have been continued until ANC recovery 25. A randomized controlled trial suggested that antibiotics can safely be discontinued before the ANC recovers if the patient is stable, afebrile for 72 hours, and an infectious source has not been identified 26.…”

Section: Managementmentioning

confidence: 99%

Evaluation and management of febrile neutropenia in patients with cancer

Cossey,

Cote

2024

Jaapa

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Febrile neutropenia is a common oncologic emergency that increases the risk for serious infection. This article reviews a joint American Society of Clinical Oncology and Infectious Diseases Society of America guideline for the evaluation and management of patients with cancer who present with fever and neutropenia. Knowledge and use of available risk assessment tools may reduce unnecessary hospitalizations, decrease inappropriate antibiotic use, and improve patient outcomes.

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“…Furthermore, radiation injury to the surrounding normal tissues, as well as the cancer patient's skin, brain, heart, lung, kidney, liver, or gastrointestinal tract, would result in unfavorable effects. Moreover, symptoms such as tissue fibrosis, hair loss, xerostomia, xerophthalmia, and others significantly limit the use of a high dose radiation targeting the tumor-bearing organs (Dest, 2006;Issani, 2022).…”

Section: E P U Lc H E R R Im a E H E Te R O P H Y Llamentioning

confidence: 99%

Enhancement of Radiation-induced Cytotoxicity in Hepatocellular Carcinoma Cells by Some Plant Extracts In vitro

2022

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R ADIOSENSITIZERS are introduced to boost cytotoxicity against tumor cells while having much less toxicity on normal cells. The radio sensitizing properties of methanolic extracts of Euphorbia pulcherrima and Euphorbia heterophylla against a hepatocellular cancer cell line were investigated in this work (HepG2). The cytotoxic effect of E. pulcherrima and E. heterophylla combined with ionizing radiation (IR) were detected. Caspase-3 levels, Bcl 2 , Bax & P53 gene expression and Annexin V-FITC apoptosis test were determined. The combination of these extracts and IR showed a considerably higher cytotoxic effect than the one using either extracts or IR alone. There is a substantial increase of Bax & P53 a combined with a decrease in Bcl2. In comparison to the control, there is a 12 to 9 fold increase in total active caspase-3. Both extracts increased the proportion of annexin-positive apoptotic cells from 1.69 percent to 17.22 percent and 14.07 percent, respectively. The combination of extracts and IR showed 17 and 11 folds higher p53 level compared to the control in the nucleus, respectively. These results showed that combined E. Pulcherrima and E. Heterophylla and IR contribute to increased cytotoxic effects on the HPG2. It can be suggested that these extracts can be used as radio-sensitizers.

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An updated narrative review on the management of the most common oncological and hematological emergencies

Cited by 6 publications

References 55 publications

Enhancement of Oncology Nurses' Competency Regarding Management of Intravenous Chemotherapy Extravasation

Enhancement of Oncology Nurses' Competency Regarding Management of Intravenous Chemotherapy Extravasation

Evaluation and management of febrile neutropenia in patients with cancer

Enhancement of Radiation-induced Cytotoxicity in Hepatocellular Carcinoma Cells by Some Plant Extracts In vitro

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