An UPLC - Q - Orbitrap method for pharmacokinetics and tissue distribution of four triterpenoids in rats after oral administration of Poria cocos ethanol extracts

Quality Evaluation of Traditional Chinese Medicine Prescription in Naolingsu Capsule Based on Combinative Method of Fingerprint, Quantitative Determination, and Chemometrics

“…As for compounds which had low content, especially Ginseng Radix et Rhizoma, Rehmanniae Radix, and Poria, or were difficult to be completely separated, we used LC-MS/MS to quantify them. The candidate ingredients were chosen based on the references of pertinent herbs, including the following 14 chemical components: XS and XZ from the minister medicine of Xanthii fructus [ 21 ]; JA and JB from the minister medicine of Ziziphi Spinosae Semen [ 22 ]; MPA from the minister medicine of Ophiopogonis Radix [ 23 ]; RD from the minister medicine of Rehmanniae Radix [ 24 ]; GRF, GRG, GRR, and GRB from the minister medicine of Ginseng Radix et Rhizoma [ 25 ]; DA, PAC, and ATA from the adjuvants medicine of Poria [ 26 ]; and PX from adjuvants medicine of the guide medicine of Polygalae Radix [ 27 ]. The chemical structures of the 25 compounds are shown in Figure S5 .…”

Pharmacological profiles and therapeutic applications of pachymic acid (Review)

“…Determination of PA (12.3 mg/kg) in rats after oral administration using UPLC-Q-Orbi-trap MS demonstrated that the pharmacokinetic parameters were terminal half-life at 11.51±9.90 h, AUC 0-∞ at 336.29±161.99 ng h/ml and CL at 45.07±73.64 L/h. PA is mainly distributed in the intestine and stomach and is considered to be further converted into other molecules in vivo ( 91 ). In addition, treatment of human liver microsomes with PA (100 µ M) demonstrated that PA inhibits cytochrome P450 (CYP)3A4, 2E1 and 2C9, with IC 50 values of 15.04, 27.95 and 24.22 µ M, respectively, indicating potential drug-drug interactions ( 92 ).…”

Preparation, characterization, antioxidant and antianemia activities of Poria cocos polysaccharide iron (III) complex

“…In the 2020 edition of the Chinese Pharmacopoeia, there are 1587 kinds of prescription preparations and single preparation, 260 of which contain Poria cocos , accounting for 16%. In addition, Poria cocos is also widely used as food [ 9 10 11 12 ]. Modern pharmacological research shows that the polysaccharides isolated from Poria cocos have many biological activities, including anti-tumor [ 13 ], anti-inflammatory [ 14 ], liver protection [ 9 ], and immunity enhancement [ 15 , 16 ], especially antioxidant effects [ 17 ].…”