1996
DOI: 10.1006/bbrc.1996.0847
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An Upstream Positive Regulatory Element in Human GM-CSF Promoter Is Recognized by NF-κB/Rel Family Members

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Cited by 19 publications
(19 citation statements)
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“…We have previously reported that epithelial cells also produce GM-CSF in response to rhinovirus infection (8). In several cell types, GM-CSF transcription has also been reported to be at least partially dependent upon NF-B activation (33,34). In time course experiments, we established that expression of GM-CSF mRNA is also rapidly induced after HRV-16 infection, with maximal expression seen 1 h postinfection.…”
Section: Effect Of Sulfasalazine On Hrv-16 Induction Of Gm-csfmentioning
confidence: 60%
See 1 more Smart Citation
“…We have previously reported that epithelial cells also produce GM-CSF in response to rhinovirus infection (8). In several cell types, GM-CSF transcription has also been reported to be at least partially dependent upon NF-B activation (33,34). In time course experiments, we established that expression of GM-CSF mRNA is also rapidly induced after HRV-16 infection, with maximal expression seen 1 h postinfection.…”
Section: Effect Of Sulfasalazine On Hrv-16 Induction Of Gm-csfmentioning
confidence: 60%
“…We have already demonstrated that rhinovirus infection of epithelial cells leads to the production of GM-CSF, a cytokine whose promoter is known to be responsive to NF-B (33,34). In contrast to IL-8 and IL-6, which are rapidly and transiently induced by HRV-16 infection, expression of GM-CSF is rapid but more sustained.…”
Section: Discussionmentioning
confidence: 99%
“…1 The 5¢-flanking regions of the CSF genes have been reported to contain putative cis-acting sites for transcription factors such as NF-kB and AP-1, [31][32][33][34][35][36][37][38][39][40] and the interaction between these regulatory transcription elements would be expected to contribute to CSF gene expression. Our EMSAs, using the NF-kB and AP-1 binding motifs, demonstrated that IL-17, IL1b, and TNF-a induced NF-kB and AP-1 DNA-binding activities in colonic SEMFs.…”
Section: Discussionmentioning
confidence: 99%
“…[31][32][33][34][35][36][37][38][39][40] To elucidate the mechanisms underlying the transcriptional activation of CSF genes in response to IL-17, IL-1b, and TNF-a, we evaluated NF-kB and AP-1 activation. As demonstrated in Fig.…”
Section: Modulation Of Transcription Factor Activationmentioning
confidence: 99%
“…The GM-CSF gene also contains an upstream element in the 5′ flanking region which is able to bind an NF-κB factor, most likely containing c-Rel. 32 In vitro effects of GM-CSF on mature neutrophils include shedding of L-selectin and priming for enhanced respiratory burst activity in response to stimulation with the peptide N-Formyl-Leu-Met-Phe (fLMP). GM-CSF is chemotactic for both neutrophils and monocytes in vitro.…”
Section: Discussionmentioning
confidence: 99%