2021
DOI: 10.1016/j.jep.2020.113697
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Analgesic and anti-inflammatory articular effects of essential oil and camphor isolated from Ocimum kilimandscharicum Gürke leaves

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Cited by 39 publications
(23 citation statements)
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“…Several species of the Ocimum genus possess multiple pharmacological properties, e.g., in vitro antimicrobial, antiviral, antimalarial activities and in vivo analgesic, anti-inflammatory, antidiarrhoeal, antidiabetic, anticancer, radiation protective, anti-hyperlipidemic activities, etc. (Ali et al 2021 ; Pandey et al 2014 ; Purushothaman et al 2018 ; Santos et al 2021 ; Singh and Chaudhuri 2018 ; Singh et al 2015 , 2016 ), whereas essential oil is valued in aromatherapy (Li and Chang 2016 ). On the other hand, silver and copper nanoparticles synthesized using aqueous leaf extract of O. americanum have shown therapeutic properties, including in vitro antibacterial, anticancer and catalytic properties, which can be used for photocatalytic dye degradation (Manikandan et al 2021a , b ).…”
Section: Introductionmentioning
confidence: 99%
“…Several species of the Ocimum genus possess multiple pharmacological properties, e.g., in vitro antimicrobial, antiviral, antimalarial activities and in vivo analgesic, anti-inflammatory, antidiarrhoeal, antidiabetic, anticancer, radiation protective, anti-hyperlipidemic activities, etc. (Ali et al 2021 ; Pandey et al 2014 ; Purushothaman et al 2018 ; Santos et al 2021 ; Singh and Chaudhuri 2018 ; Singh et al 2015 , 2016 ), whereas essential oil is valued in aromatherapy (Li and Chang 2016 ). On the other hand, silver and copper nanoparticles synthesized using aqueous leaf extract of O. americanum have shown therapeutic properties, including in vitro antibacterial, anticancer and catalytic properties, which can be used for photocatalytic dye degradation (Manikandan et al 2021a , b ).…”
Section: Introductionmentioning
confidence: 99%
“…O tratamento com o seu óleo essencial inibiu significativamente o edema induzido por carragenina, hiperalgesia mecânica e fria. Ambos, o óleo essencial de O. kilimandscharicum e a cânfora inibiram significativamente a rolagem de leucócitos induzida por carragenina e a adesão, confirmando sua capacidade anti-inflamatória, contribuindo, pelo menos em parte, para explicar o uso popular das folhas de O. kilimandscharicum contra a dor (Santos et al, 2021).…”
Section: Plantas Medicinais Com Atividade Anti-inflamatóriaunclassified
“…A cânfora é o principal constituinte do óleo essencial de Ocimum kilimandscharicum e foi cientificamente estudada por suas propriedades analgésicas, antiedematogênicas e cardiovasculares. Outros constituintes deste óleo, como 1,8-cineol, pineno e limoneno também mostraram atividade anti-inflamatória (Santos et al, 2021).…”
Section: Constituintes Químicos Responsáveis Pela Atividade Anti-inflamatóriaunclassified
“…This explanation would also explain why orris maintained a position in modern British pharmacopoeias due to its ability to cure dropsy (Crisan and Cantor 2016). In many of the sources cited for the anti-inflammatory molecules (Bhowal and Gopal 2016, Cheriet et al 2020, dos Santos et al 2021, Ibrahim et al 2012, Jain and Joshi 2012, Lim et al 2008, Min et al 2009, Peana et al 2003, Santosa et al 2004, the anti-inflammatory action of the molecule was determined by its ability to reduce experimentally-induced edema, which is a synonym for dropsy.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, dos Santos et al (2021) found that camphor had in vivo antiinflammatory potential through inhibition of leukocyte-endothelium interaction, and reduction of IL-1β, IL-4, and TNF. This mechanism was also linked to analgesic effects, particularly against articular pain.…”
Section: (+)-Camphormentioning
confidence: 99%