Analgesic Effect from Ibuprofen Nanoparticles Inhaled by Male Mice

Onischuk, A. A.; Толстикова, Т. Г.; Сорокина, И. В.; Жукова, Н. А.; Baklanov, A.; Карасев, В. Е.; Borovkova, Olga V.; Dultseva, G.G.; Болдырев, В. В.; Fomin, V. M.

doi:10.1089/jamp.2008.0721

Cited by 33 publications

(15 citation statements)

References 13 publications

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“…The effect of temperature 77 , initial film thickness 78 and energy 79 on the condensation aerosol was previously studied. The method was successfully used to make ibuprofen and indomethacin nanoparticles for inhalation 80,81 .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Inhalable nanoparticulate powders for respiratory delivery

Muralidharan

Malapit

Mallory

et al. 2015

Nanomedicine: Nanotechnology, Biology and Medicine

189

123

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Section: Accepted Manuscriptmentioning

confidence: 99%

Inhalable nanoparticulate powders for respiratory delivery

Muralidharan

Malapit

Mallory

et al. 2015

Nanomedicine: Nanotechnology, Biology and Medicine

189

123

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“…In addition, intubation includes a much higher risk of injury to the animal that could compromise the study. Aerosol administration via a nebulizer-based device [8], [9], [10], [11] also offers very efficient delivery of materials to the lungs with little risk of injury to the animal; however, this method is technically demanding and requires expensive equipment that is not widely available. Moreover, the use of aerosol generators for studies involving dangerous pathogens involves safety issues for research personnel that do not exist when using the intranasal delivery method.…”

Section: Introductionmentioning

confidence: 99%

Visualization of Murine Intranasal Dosing Efficiency Using Luminescent Francisella tularensis: Effect of Instillation Volume and Form of Anesthesia

et al. 2012

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Intranasal instillation is a widely used procedure for pneumonic delivery of drugs, vaccine candidates, or infectious agents into the respiratory tract of research mice. However, there is a paucity of published literature describing the efficiency of this delivery technique. In this report we have used the murine model of tularemia, with Francisella tularensis live vaccine strain (FTLVS) infection, to evaluate the efficiency of pneumonic delivery via intranasal dosing performed either with differing instillation volumes or different types of anesthesia. FTLVS was rendered luminescent via transformation with a reporter plasmid that constitutively expressed the Photorhabdus luminescens lux operon from a Francisella promoter. We then used an IVIS Spectrum whole animal imaging system to visualize FT dissemination at various time points following intranasal instillation. We found that instillation of FT in a dose volume of 10 µl routinely resulted in infection of the upper airways but failed to initiate infection of the pulmonary compartment. Efficient delivery of FT into the lungs via intranasal instillation required a dose volume of 50 µl or more. These studies also demonstrated that intranasal instillation was significantly more efficient for pneumonic delivery of FTLVS in mice that had been anesthetized with inhaled (isoflurane) vs. parenteral (ketamine/xylazine) anesthesia. The collective results underscore the need for researchers to consider both the dose volume and the anesthesia type when either performing pneumonic delivery via intranasal instillation, or when comparing studies that employed this technique.

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“…Òåõíîëîãèþ ïîëó÷åíèÿ àýðîçîëåé ñì. [3]. Äëÿ ïîëó÷åíèÿ àýðîçîëÿ èñïîëüçîâàëè ñóáñòàíöèè ëåêàðñòâåííûõ ïðåïàðàòîâ ôèðìû Fluka (Èòàëèÿ, 99,0 %).…”

Section: ýêñïåðèìåíòàëüíàÿ ÷àñòüunclassified

“…Âî âðåìÿ îïûòîâ aeèâîòíûõ ïîìåùàëè ïî îäíîìó â ñòåêëÿííûå êàìåðû, êîòîðûå ñîîáùàëèñü ñ ïîòîêîì àýðîçîëÿ ÷åðåç íåáîëüøîå îòâåðñòèå. Ìåòîäèêà îïðåäåëåíèÿ èíãàëÿöèîííîé äîçû îïèñàíà â [3,4,6,8,9].…”

Section: ýêñïåðèìåíòàëüíàÿ ÷àñòüunclassified

“…Àâòîðàìè äàííîãî ñîîáùåíèÿ áûë ïðåäëîaeåí ìåòîä ãîìîãåííîé íóêëåàöèè ïåðåñûùåííûì ïàðîì [6] äëÿ ïîëó÷åíèÿ àýðîçîëåé ÍÏÂÑ ñ âûñîêîé êîíöåíòðàöèåé è ñòàáèëüíîñòüþ íàíî÷àñòèö ðàçìåðîì îò 20 -220 íì. Â ýêñïåðèìåíòàõ íà aeèâîòíûõ áûëî ïîêàçàíî, ÷òî ïîëó÷åííûå ýòèì ìåòîäîì íàíîàýðîçîëè èíäîìåòàöèíà, äèêëîôåíàêà è èáóïðîôåíà íàòðèÿ â ñóáìàëûõ äîçàõ ïðîÿâëÿþò ïðîòèâîâîñïàëèòåëüíûé ýôôåêò [3,8], à èáóïðîôåí îêàçûâàåò òàêaeå è àíàëüãåòè÷åñêîå äåéñòâèå [3 -5].…”

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Анальгетический Эффект Наноаэрозольной Формы Некоторых Нестероидных Противовоспалительных Препаратов

Аньков¹,

Толстикова²,

Онищук³

et al. 2015

Хим.-фарм. ж.

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Изучена анальгетическая активность наноаэрозольной формы нестероидных противовоспалительных средств — индометацина, бутадиона и диклофенака. Установлено, что, в сравнении с традиционным способом введения данных препаратов, наноаэрозольный способ доставки имеет аналогичную анальгетическую активность через 5 – 8 мин после введения в дозе от 3 до 5 порядков ниже пероральной.

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Analgesic Effect from Ibuprofen Nanoparticles Inhaled by Male Mice

Cited by 33 publications

References 13 publications

Inhalable nanoparticulate powders for respiratory delivery

Inhalable nanoparticulate powders for respiratory delivery

Visualization of Murine Intranasal Dosing Efficiency Using Luminescent Francisella tularensis: Effect of Instillation Volume and Form of Anesthesia

Анальгетический Эффект Наноаэрозольной Формы Некоторых Нестероидных Противовоспалительных Препаратов

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