Analgesic Effect of Electroacupuncture on Paclitaxel-induced Neuropathic Pain via Spinal Opioidergic and Adrenergic Mechanisms in Mice

Choi, Jung-Wan; Kang, Suk-Yun; Choi, Jae-Gyun; Kang, Dong-Wook; Kwon, O Sang; Yeon, Sun Hee; Cho, Seong Jin; Choi, Kwang-Dong; Ryu, Yeonhee; Kim, Hyun-Woo

doi:10.1016/j.imr.2015.04.066

Cited by 2 publications

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“…Electroacupuncture (EA) is a modified acupuncture technique that induced analgesic effects on neuropathic pain have been reported in several clinical studies. 11–13 Previously studies found that EA at specific acupoints can improve the clinical symptoms of peripheral neuropathy, 14,15 which may be related to the improvement of the peripheral nerve conduction velocity, and some patients can even achieve healing. Although it has not been studied whether or how EA treatment of OIPN, the possible mechanisms including (1) the electric field of acupuncture is beneficial to the regeneration of injured nerve and the improvement of ion channel function 16 ; (2) the electric field of acupuncture can promote the growth of nerve growth–associated proteins 17 ; and (3) the electric field of acupuncture can promote the expression of S-100 protein in Schwann cells.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Molecular mechanism of electroacupuncture treatment on oxaliplatin-induced peripheral neurotoxicity in rats

Shan-shan¹,

Yang²,

Sun

et al. 2020

Eur J Inflamm

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Oxaliplatin (L-OHP) has been widely used in the treatment of various tumors, especially in colorectal cancer. The mechanism of peripheral neurotoxicity induced by L-OHP (OIPN) is unclear and current therapeutic options only serve to alleviate the symptoms rather than prevent OIPN. To observe the effects of electroacupuncture (EA) stimulation on OIPN in rats, rats were randomly divided into the control group, OIPN model group, and OIPN + EA group. To establish OIPN rat models, a single intraperitoneal injection with 10 mg/kg L-OHP in the OIPN model rats. Rats in the control group received a single intraperitoneal injection with 0.9% lactose. From the third day after establishing OIPN models, the rats were treated with EA. Cold allodynia and heat sensitivity were assessed using the acetone drop and the Hargreaves method, respectively. Pathological changes in nerves were detected using hematoxylin and eosin (H&E) staining and transmission electron microscopy. Related mRNA and protein expression levels were measured by real-time polymerase chain reaction (PCR) and western blotting from 14 days after establishing OIPN models. Our results showed that L-OHP significantly increased the sensitivity to cold allodynia and nervous injury, which were ameliorated after EA treatment. The expression of glucocorticoid receptor alpha (GR-α) and B-cell lymphoma 2 (Bcl-2) was significantly decreased and that of Bax was significantly increased in sciatic nerve of OIPN model rats compared with control rats. However, EA treatment significantly inhibited L-OHP-induced protein expressions in rats. Moreover, compared with the control rats, the nucleus NF-κBp65 levels were significantly increased, while the cytoplasm NF-κBp65 levels were significantly decreased, which were reversed by EA treatment. In conclusion, EA treatment may reduce peripheral neurotoxicity induced by L-OHP through regulating related protein expression.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Molecular mechanism of electroacupuncture treatment on oxaliplatin-induced peripheral neurotoxicity in rats

Shan-shan¹,

Yang²,

Sun

et al. 2020

Eur J Inflamm

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show abstract

“…In another study to affirm the effectiveness of EA and determining relation mechanism of EA and PTX-induced neuropathic pain, 12) Acupuncture treatment has been raised as a treatment for CIPN according to some articles.…”

Section: Effect Through α2-and β-Adrenoceptors Opioid Receptormentioning

confidence: 99%

A Suggestion on the Action Mechanisms of Acupuncture Treatment for Controlling Chemotherapy-Induced Peripheral Neuropathy

et al. 2020

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Analgesic Effect of Electroacupuncture on Paclitaxel-induced Neuropathic Pain via Spinal Opioidergic and Adrenergic Mechanisms in Mice

Cited by 2 publications

References 0 publications

RETRACTED: Molecular mechanism of electroacupuncture treatment on oxaliplatin-induced peripheral neurotoxicity in rats

RETRACTED: Molecular mechanism of electroacupuncture treatment on oxaliplatin-induced peripheral neurotoxicity in rats

A Suggestion on the Action Mechanisms of Acupuncture Treatment for Controlling Chemotherapy-Induced Peripheral Neuropathy

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