2010
DOI: 10.2147/jpr.s12520
|View full text |Cite
|
Sign up to set email alerts
|

Analgesic effects of intra-articular botulinum toxin Type B in a murine model of chronic degenerative knee arthritis pain

Abstract: Objective:To evaluate the analgesic effectiveness of intra-articular botulinum toxin Type B (BoNT/B) in a murine model of chronic degenerative arthritis pain.Methods and materials:Chronic arthritis was produced in adult C57Bl6 mice by intra-articular injection of Type IV collagenase into the left knee. Following induction of arthritis, the treatment group received intra-articular BoNT/B. Arthritic control groups were treated with intra-articular normal saline or sham injections. Pain behavior testing was perfo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
18
0

Year Published

2013
2013
2018
2018

Publication Types

Select...
9

Relationship

1
8

Authors

Journals

citations
Cited by 26 publications
(20 citation statements)
references
References 28 publications
0
18
0
Order By: Relevance
“…This broad approach has been promoted for improving the translational value of preclinical studies and to help refine the understanding of the specific analgesic mechanisms of the compounds under study. [53][54][55][56] Our studies were designed to address these goals, and the data obtained were consistent in demonstrating a broad potential spectrum of analgesic activity. For example, our first observations provided evidence of curcumin's ability to reverse both thermal and mechanical sensitization for several days after incision.…”
Section: Discussionmentioning
confidence: 85%
“…This broad approach has been promoted for improving the translational value of preclinical studies and to help refine the understanding of the specific analgesic mechanisms of the compounds under study. [53][54][55][56] Our studies were designed to address these goals, and the data obtained were consistent in demonstrating a broad potential spectrum of analgesic activity. For example, our first observations provided evidence of curcumin's ability to reverse both thermal and mechanical sensitization for several days after incision.…”
Section: Discussionmentioning
confidence: 85%
“…As SNAREs mediate most vesicular release, it is not surprising that toxins such as BoNT-A and B cleaving respectively SNAP-25 or VAMP also block release of primary afferent transmitters (substance P (SP) and calcitonin gene-related peptide (CGRP)) after local application in ex vivo [25; 74] and in vivo models [38]. Peripherally delivered BoNTs have no effect upon acute pain thresholds, but exhibit a homotopic antihyperalgesic effect in rodent models of inflammation and arthritis [2; 7; 8; 20; 26; 57; 69; 71] and in models of mono- and poly-neuropathy [8-10; 56; 59; 67; 79]. These results parallel human studies where local BoNTs have no effect upon acute thresholds [12; 34; 89; 101], but reduce hyperesthesia in postherpetic neuralgia [39; 55; 104], diabetic neuropathy [108], nerve injury [30; 81; 83], residual limb pain [47] and in certain forms of migraine [22; 24].…”
Section: Introductionmentioning
confidence: 99%
“…The most frequently used method for assessing the severity of carrageenan-induced arthritis is a semiquantitative clinical scoring system. It is based on the degree of inflammation and swelling in the joints and vocal and/or physical displays of pain behavior 3,4. Both the clinical scoring system and the elicitation of pain behavior displays are subjective measures that are time- and labor-intensive.…”
Section: Introductionmentioning
confidence: 99%