Análise comparativa do efeito de dois protocolos de ultrassom terapêutico para regeneração de defeito ósseo crítico

Daltro, Ana Flávia Calmon; Barreto, Isabela Cerqueira; Almeida, Renata dos Santos; Ribeiro, Iorrana Índira dos Anjos; Barbosa, Aryon de Almeida; Rosa, Fabiana Paim

doi:10.1055/s-0039-3402457

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…In addition, the literature shows that up to 20% of fractures evolve with a delayed or no repair. Among the factors contributing to this complication of non-consolidation is the location of the bone lesion, the treatment method applied, and the characteristics of the patient's lifestyle and type ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…A simple radiology examination is one of the methods used for evaluating bone repair and can be used to assess the evolution of bone defect repairs in the skeleton ( 5 , 6 ). However, there are other methods, such as nuclear magnetic resonance ( 7 ), computed tomography ( 8 ), ultrasound ( 3 ), and bone scintigraphy ( 3 , 9 ). Bone scintigraphy is an imaging procedure that demonstrates bone metabolic activity.…”

Section: Introductionmentioning

confidence: 99%

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Temporal evolution of postsurgical bone repair in a rabbit model: A [99mTc]Tc-MDP scintigraphic study

Yoneda,

Lacerda,

Alexandre-Santos

et al. 2024

Braz J Med Biol Res

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Bone regeneration is crucial for repairing bone tissue following various injuries. Research techniques that enable the study of metabolic changes in bone tissue under different conditions are important for understanding bone repair and remodeling. This study used bone scintigraphy to evaluate osteogenesis secondary to osteotomy in a preclinical model of New Zealand rabbits. For this purpose, we conducted a longitudinal, prospective, case-control study in which scintigraphic variables were measured in both the right forearm (case-operated) and the left forearm (control - non-operated). The study sample consisted of 10 rabbits subjected to osteotomy, followed by a 12-week postoperative evaluation period, divided into six imaging stages at 1, 2, 3, 4, 8, and 12 weeks. We observed that the operated forearm showed significantly higher external radiation than the control side, using the pinhole collimator, denoting an increase in the biodistribution and tropism of the radiopharmaceutical to the operated forearm. Among the three evaluated time points, osteoblastic activity was highest in the second week and presented a significant decline in the 8th and 12th weeks, denoting regeneration and resolution of the surgical injury; the control forearm was also influenced by the inactivity imposed by the operated forearm. This fact was notably evidenced by the reduction in the metabolic activity of osteoblasts in the left forearm. Our study suggested that bone scintigraphy was sensitive enough to semi-quantitatively differentiate the metabolic activity of osteoblasts in the operated forearm in the three temporal landmarks evaluated in the study.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Temporal evolution of postsurgical bone repair in a rabbit model: A [99mTc]Tc-MDP scintigraphic study

Yoneda,

Lacerda,

Alexandre-Santos

et al. 2024

Braz J Med Biol Res

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“…2017). Segundo Daltro et al (2020) emite ondas de alta frequência de pressão acústica que, ao interagir com os tecidos biológicos, promovem alterações micromecânicas. Essas alterações geram eventos bioquímicos capazes de acelerar a consolidação de fraturas, estimular o reparo de tecidos lesionados, como o tecido ósseo e o muscular, inibir respostas inflamatórias e participar do processo de modulação da dor.…”

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Influência da velocidade da movimentação do transdutor na administração da terapia ultrassônica pulsada na cicatrização de feridas cutâneas em ratos / Influence of transducer drive speed on ultrasonic pulsed therapy management in the healing of skin wounds in rats

Santos¹,

Sousa²,

Reis³

et al. 2022

Braz. J. Hea. Rev.

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Collagen-chitosan-hydroxyapatite composite scaffolds for bone repair in ovariectomized rats

Chacon

Bertolo

Plepis

et al. 2023

Sci Rep

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Lesions with bone loss may require autologous grafts, which are considered the gold standard; however, natural or synthetic biomaterials are alternatives that can be used in clinical situations that require support for bone neoformation. Collagen and hydroxyapatite have been used for bone repair based on the concept of biomimetics, which can be combined with chitosan, forming a scaffold for cell adhesion and growth. However, osteoporosis caused by gonadal hormone deficiency can thus compromise the expected results of the osseointegration of scaffolds. The aim of this study was to investigate the osteoregenerative capacity of collagen (Co)/chitosan (Ch)/hydroxyapatite (Ha) scaffolds in rats with hormone deficiency caused by experimental bilateral ovariectomy. Forty-two rats were divided into non-ovariectomized (NO) and ovariectomized (O) groups, divided into three subgroups: control (empty defect) and two subgroups receiving collagen/chitosan/hydroxyapatite scaffolds prepared using different methods of hydroxyapatite incorporation, in situ (CoChHa1) and ex situ (CoChHa2). The defect areas were submitted to macroscopic, radiological, and histomorphometric analysis. No inflammatory processes were found in the tibial defect area that would indicate immune rejection of the scaffolds, thus confirming the biocompatibility of the biomaterials. Bone formation starting from the margins of the bone defect were observed in all rats, with a greater volume in the NO groups, particularly the group receiving CoChHa2. Less bone formation was found in the O subgroups when compared to the NO. In conclusion, collagen/chitosan/hydroxyapatite scaffolds stimulate bone growth in vivo but abnormal conditions of bone fragility caused by gonadal hormone deficiency may have delayed the bone repair process.

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Análise comparativa do efeito de dois protocolos de ultrassom terapêutico para regeneração de defeito ósseo crítico

Cited by 3 publications

References 24 publications

Temporal evolution of postsurgical bone repair in a rabbit model: A [99mTc]Tc-MDP scintigraphic study

Temporal evolution of postsurgical bone repair in a rabbit model: A [99mTc]Tc-MDP scintigraphic study

Influência da velocidade da movimentação do transdutor na administração da terapia ultrassônica pulsada na cicatrização de feridas cutâneas em ratos / Influence of transducer drive speed on ultrasonic pulsed therapy management in the healing of skin wounds in rats

Collagen-chitosan-hydroxyapatite composite scaffolds for bone repair in ovariectomized rats

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