“…These studies investigated the use of MTA, EndoSequence ERRM and Biodentine in the root perforation that happened during the endodontic treatment on human and animal studies. All the studies included in this systematic review were eleven In-vitro studies 8,10,12,13,20,26,[28][29][30][31][32] , two In-vivo studies 2,17 , one Randomized controlled trial study (RCT) 33 , four Retrospective clinical studies 18,[34][35][36] , and four Case reports. 1,7,9,37 In regard to the types of root repair materials performed, fourteen studies were performed with MTA in a combination of other root repair materials such as ERRM and Biodentine.…”