Análise química e atividades biológicas de &lt;i&gt;Guatteria elliptica&lt;/i&gt; R. E. Fries (Annonaceae)

Ferreira, Agnieszka Katarzyna Rajca

doi:10.11606/t.9.2016.tde-19052016-150855

Cited by 3 publications

(4 citation statements)

References 56 publications

(115 reference statements)

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“…Another plant species of the family Annonaceae (Guatteria elliptica R. E. Fries) that is rich in alkaloids, demonstrated antimicrobial activity by the turbidimetric method [34]. Therefore, even if this organic group is not known for the antimicrobial action, it is possible that there are species-rich in alkaloids and with this activity.…”

Section: Resultsmentioning

confidence: 99%

Larvicidal Evaluation of Aedes aegypti and Antioxidant, Cytotoxic and Antimicrobial Potential of the Aqueous Acid Extract of Pseudoxandra cuspidata (ANNOACEAE).

Simões¹,

Martins²,

Rabelo³

et al. 2021

JPP

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The Anonnaceae family has 2,500 species and 135 genera, which has about 14 representatives of species in Brazil, including Pseudoxandra cuspidata. The objective of this research was to study the aqueous-acid extract of P. cuspidata, evaluating its antioxidant, larvicidal, antimicrobial and cytotoxic potential. In the preliminary phytochemical analysis, there were positivity to organicacids and alkaloids. Inhibitory Activity of EAA was 65% against DPPH. The AAE presented to A. Salina nauplii at LC50% of 600.79 μg/mL for a periodof 24 hours. In relation to larvicidal activity to Aedes aegypti intermediates, AAE presented the LC50% in 24 Hours of 475.91 ppm and 290.73 ppm in 48 Hours. Regarding the antimicrobial action, the EAA presented 50 mg/mL MIC for P. Aeruginosa and MBC at 100 mg/mL, and for S. aureus it presented MIC of 50 mg/mL and did not present MBC. This research characterized the presence of alkaloids and organicacids present in the aqueousacid extract of P. cuspidata. The extract presented lowtoxicity in relation to the microcrustacean A. salina. It also had a relevant antioxidant potential (65% of Inhibition), larvicidalaction considered effective, antimicrobialaction for both P. Aeruginosa and S. Aureus even did not present bacterici dalaction.

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Section: Resultsmentioning

confidence: 99%

Larvicidal Evaluation of Aedes aegypti and Antioxidant, Cytotoxic and Antimicrobial Potential of the Aqueous Acid Extract of Pseudoxandra cuspidata (ANNOACEAE).

Simões¹,

Martins²,

Rabelo³

et al. 2021

JPP

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“…Isolated alkaloids of Guatteria sp. (family Annonaceae) have antitumor, antimalarial, antifungal and mutagenic activities 53 . The chemical composition and biological activity of essential oils from species of basal angiosperms may be related, as their compounds are detoxification products of harmful substances generated by the primary metabolism of plants, acting as allelopathic agents, which can inhibit germination owing to their chelating and/or cytotoxic power 54 .…”

Section: Results Chemical Composition Of the Essential Oils The Extrmentioning

confidence: 99%

Phytocytotoxicity of volatile constituents of essential oils from Sparattanthelium Mart. species (Hernandiaceae)

Dutra

Christ

Carrijo

et al. 2020

Sci Rep

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praça-fontes 1,3* the intensive application of agrochemicals in crops has negatively impacted the environment and other organisms. The use of naturally occurring compounds may be an alternative to mitigate these effects. Plants are secondary metabolite reservoirs and may present allelopathic activity, which is potentially interesting to be used in bioherbicide formulations. In this context, the present work aimed to evaluate the phytotoxic and cytotoxic effects of essential oils extracted from leaves of Sparattanthelium botocudorum and Sparattanthelium tupiniquinorum in bioassays with the plant models Lactuca sativa L. and Sorghum bicolor L. Moench. The essential oils were applied at concentrations of 3,000, 1,500, 750, 375 and 187.5 ppm. Chemical characterization of the oils was performed, and their impact on the percentage of germinated seeds, initial development of L. sativa and S. bicolor seedlings, and changes in the mitotic cycle of meristematic cells from L. sativa roots was evaluated. The major compound of the essential oils was germacrene D, followed by bicyclogermacrene, β-elemene and germacrene A. The phytotoxicity assay showed that the essential oils of both species reduced the root and shoot growth in L. sativa and decreased the germination and shoot growth in S. bicolor. Inhibition was dependent on the tested oil concentration. In the cytotoxicity assay, a decrease in mitotic index and chromosomal and nuclear alterations were observed, which resulted from aneugenic and clastogenic action. Herbicides, which are used for weed control 1 , are among the most applied agrochemicals in crop fields. However, the use of these compounds has led to problems related to plant resistance, environmental contamination, and risks to human and animal health. Therefore, it is necessary to find alternative methods for agricultural pest control 2,3. In this context, secondary metabolites may be of particular interest, as they can be directly or indirectly used in the development of new herbicides. These compounds are produced by plants and comprise three major groups, which are found in extracts and essential oils: terpenoids, alkaloids and phenolic compounds 4,5. Essential oils play an important role in protecting the plant during the competition with other species as well as against herbivore and pest attacks, and are produced variably according to the plant's interactions with the environment 6. Essential oils are volatile products, found in all plant organs, and are obtained by extraction processes such as hydrodistillation and cold pressing, depending on plant location, quantity and characteristics required for the final product 7-9. The identification and phytochemical classification of these oils enable the investigation of biologically active substances 10-12. Known as allelochemicals, these substances can be a favorable source for the development of natural herbicides, which may contribute to reduce the environmental impact caused by commercial herbicides, and additionally serve as plant growth stimulants 13-16 .

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“…It could be considered a repurposing [30] antidepressant. [31] With this study, Fernandes-Gomez and co-workers [29] were able to establish a structure-activity relationship for the inhibition of TR. The higher activity of 23 compared to the other compounds indicates that a 3-methylene spacer group located between the two amino groups is superior to that consisting of 2 methylene.…”

Section: Trypanothione Reductasementioning

confidence: 93%

“…The most active compound was ( 23 ), Ki 27 μM, which was comparable to clomipramine (Figure 5), the most potent TR inhibitor. It could be considered a repurposing [30] antidepressant [31] …”

Section: Introductionmentioning

confidence: 99%

The Importance of the Piperazine Ring for the Development of Trypanomicide Compounds

Gomes Pernichelle,

Tavares Marcelino Alves,

Massarico Serafim

et al. 2023

ChemistrySelect

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Chagas disease (CD) is one of extremely Neglected Tropical Diseases (NTD) that have been challenging the health of billions of people in the world. Despite being a threat worldwide many of these diseases have a scarce chemotherapeutic armamentarium and the drugs currently used are not effective because of several reason, such as drug resistance, serious side‐effects, among others. Only two drugs are currently available for CD therapeutics, and they are not active in the chronic phase of the diseases. Considering the huge necessity of drugs for this parasitosis, the search for either new or better drugs than those used, many research groups have been involved in this investigation. New scaffolds can be used with this purpose and piperazine is one of them. Since it has many chemical, pharmacological and pharmacokinetics advantages, including multitarget activity, this group has been often used in CD. In this review, which the role of piperazine group in the structure‐activity of some important targets for T. cruzi, as cruzain, trypanothione reductase, Fe‐superoxide dismutase, and nitroreductase as well, is comprehended, several examples have been given to inspire researchers to optimize either hit or lead compounds against T. cruzi.

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Análise química e atividades biológicas de <i>Guatteria elliptica</i> R. E. Fries (Annonaceae)

Abstract: Rajca-Ferreira, A.K. Chemical analysis and biological activities of Guatteria elliptica R. E. Fries (Annonaceae). 2016. 201f. Tese (Doutorado)

Cited by 3 publications

References 56 publications

Larvicidal Evaluation of Aedes aegypti and Antioxidant, Cytotoxic and Antimicrobial Potential of the Aqueous Acid Extract of Pseudoxandra cuspidata (ANNOACEAE).

Larvicidal Evaluation of Aedes aegypti and Antioxidant, Cytotoxic and Antimicrobial Potential of the Aqueous Acid Extract of Pseudoxandra cuspidata (ANNOACEAE).

Phytocytotoxicity of volatile constituents of essential oils from Sparattanthelium Mart. species (Hernandiaceae)

The Importance of the Piperazine Ring for the Development of Trypanomicide Compounds

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