Análisis de la morbilidad postoperatoria en pacientes con adenocarcinoma gástrico tratados según protocolo de quimiorradioterapia preoperatoria y cirugía

Valentí, Víctor; Hernández-Lizoain, José Luís; Regueira, Fernando Martínez; Gil, A.; Martí, Pablo; Zozaya, Gabriel; Bueno, Álvaro; Pedano, Nicolás; Arredondo, Jorge; Beorlegui, M. Carmen; Cienfuegos, Javier A.

doi:10.1016/j.ciresp.2009.08.005

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…yaptığı çalışmalar da neoadjuvan kemoterapi yapılan hastaların genel yaşam sürelerinin daha uzun olduğu saptanmıştır. Oysa Valenti [12] ve Biffi ve ark. [13] çalışmalar da ise neoadjuvan kemoterapi sonrası cerrahi tedavi yapılan hastalar ile standart cerrahi tedavi yapılan hastaların genel sağkalım sürelerinde anlamlı bir fark saptanmamıştır.…”

Section: Discussionunclassified

Overall Survival Results with Surgical Treatment After Neoadjuvant Chemotherapy in Local Invasive Gastric Cancers

Ertuğrul¹

2019

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Objectives: Gastric cancer is a very common and fatal cancer. The only known curative treatment is radical gastrectomy. This retrospective study compared the overall survival results of surgical treatment after neoadjuvant chemotherapy and standard surgical treatment. Methods:The records of 90 patients from a single center who had locally invasive gastric cancer were evaluated retrospectively. Of those, 45 patients (50%) underwent neoadjuvant chemotherapy and surgical treatment. Results:Patients who underwent surgical treatment after neoadjuvant chemotherapy for locally invasive gastric cancer were found to have a general survival time of 16.6 months, while it was 15.6 months for those who pursued standard surgical treatment. Conclusion:In this study, there was no significant difference in terms of overall survival between surgical treatment after neoadjuvant chemotherapy and standard surgical treatment for patients with gastric cancer. ÖZETAmaç: Mide kanseri son derece sık görülen ve ölümcül seyreden bir kanserdir. Bilinen tek küratif tedavisi radikal gastrektomidir. Bu retrospektif çalışma ile neoadjuvan kemoterapi sonrası cerrahi tedavi ile standart cerrahi tedavinin genel sağ kalım sonuçları karşılaştırılmıştır.Yöntem: Merkezimizde lokal ileri evre mide kanseri tanısıyla cerrahi tedavi uygulanan 90 hasta retrospektif olarak değerlendirildi. Hastaların 45'ine (%50) neoadjuvan kemoterapi sonrası cerrahi tedavi uygulanmıştı.Bulgular: Lokal ileri evre mide kanseri nedeniyle neoadjuvan kemoterapi sonrası cerrahi tedavi uygulanan hastalar da genel sağkalım süresi 16.6 ay, standart cerrahi tedavi uygulanan hastalar da 15.6 ay olarak bulundu.Sonuç: Bu çalışmada neoadjuvan kemoterapi sonrası cerrahi tedavi ile standart cerrahi tedavi arasında genel sağkalım süreleri açısından fark bulunmadı.Anahtar sözcükler: Mide kanseri; neoadjuvan kemoterapi; radikal gastrektomi.

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Section: Discussionunclassified

Overall Survival Results with Surgical Treatment After Neoadjuvant Chemotherapy in Local Invasive Gastric Cancers

Ertuğrul¹

2019

bogazicitip

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“…[1–3] And nowadays, most RCT (randomized control trial) focus on the long-term effects that patients can benefit from NACT rather than the side effects it brings in the short term [3, 4]. Although many studies, which engaged in proving the safety of using NACT, exhibited no significant difference in overall postoperative complications [5–7], few papers mentioned that postoperative infections were more common in patients who underwent NACT [8]. Given that chemotherapy has been known to cause bone marrow suppression [9] and intestinal barrier structural damage [10] in animal models which might raise the risk for infection, so we hypothesize that intestinal barrier injuries are the key point between preoperative chemotherapy and postoperative infections.…”

Section: Introductionmentioning

confidence: 99%

The influence of neoadjuvant chemotherapy on gastric cancer patients’ postoperative infectious complications: What is the negative role played by the intestinal barrier dysfunction?

et al. 2017

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Evidence has shown that neoadjuvant chemotherapy (NACT) is correlated with patients’ overall postoperative complications. But investigations on relationship between NACT and postoperative infectious complications, which is closely linked to intestinal barrier damage, were scanty. Accordingly, 90 patients with advanced gastric cancer were included in this study. The differences in postoperative infectious complications were determined between NACT group in which patients received NACT before surgery and SURG group in which received surgical treatment immediately after diagnosis. The damage of mechanical structure of intestinal barrier was assessed by hematoxylin and eosin staining, transmission electron microscopy, and immunohistochemistry. Mucosal microbiota changes were determined by using a 16S rRNA gene sequencing approach. Results showed that the incidence of postoperative infectious complications were significantly higher in the NACT group. Tight junctions were disrupted, and claudin-1, ZO-1 and occludin were down-regulated in patients with infectious complications in overall compared with those without. And similarly, the patients in the NACT group also showed damaged intestinal barrier compared with those in SURG group. Besides, the total diversity of mucosal related bacteria was decreased and relative abundance of some probiotics, such as Bifidobacterium, Faecalibacterium and Ruminococcus, was reduced in the NACT group as well. In conclusion, our study identifies a higher incidence of postoperative infection in gastric cancer patients who underwent NACT treatment, and these changes might be caused by a significant damage in the intestinal barrier as well as reduced probiotics.

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Docetaxel-Based Preoperative Chemoradiation in Localized Gastric Cancer: Impact of Pathological Complete Response on Patient Outcome

Rostom

Zaghloul

Khedr

et al. 2012

J Gastrointest Canc

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Análisis de la morbilidad postoperatoria en pacientes con adenocarcinoma gástrico tratados según protocolo de quimiorradioterapia preoperatoria y cirugía

Cited by 4 publications

References 27 publications

Overall Survival Results with Surgical Treatment After Neoadjuvant Chemotherapy in Local Invasive Gastric Cancers

Overall Survival Results with Surgical Treatment After Neoadjuvant Chemotherapy in Local Invasive Gastric Cancers

The influence of neoadjuvant chemotherapy on gastric cancer patients’ postoperative infectious complications: What is the negative role played by the intestinal barrier dysfunction?

Docetaxel-Based Preoperative Chemoradiation in Localized Gastric Cancer: Impact of Pathological Complete Response on Patient Outcome

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