2015
DOI: 10.1016/j.bpj.2014.11.1277
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Analysing Small DNA Constructs via a Chromophore Model within the Point Dipole Approximation

Abstract: their dysregulation in disease. However, the molecular mechanisms that drive these phase transitions, the biophysical properties of the resulting droplets, and the way their properties impact biological function, remain poorly understood. Here, we focus on LAF-1, an essential DEAD-box RNA helicase associated with P granules in the C. elegans germline. We find that purified LAF-1 can phase separate into liquid droplets at near physiological (low mM) concentrations. LAF-1 droplet formation is driven by its disor… Show more

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