GeoGebra is an interactive geometry, algebra, statistics, and calculus application designed for teaching and learning math, science, and engineering. Its dynamic interface allows its users to accurately and interactively visualize their work, models, and results. GeoGebra employs the synthesis of three key features: modeling, visualization, and programming (MVP). Many studies have shown the positive effects of GeoGebra on the efficiency and effectiveness of learning and teaching topics related to science, technology, engineering, and mathematics. In this study, we discuss how GeoGebra provides an environment for learning that is very interactive and collaborative between the learner and the instructor. We also show how integrating GeoGebra into the learning scheme can help improve the skills and knowledge of school and university students in numerous advanced mathematical courses, such as calculus, mathematical statistics, linear algebra, linear programming, computer-aided design, computer-aided geometric design, analytic and projective geometry, and graphical representation. Therefore, this study shows the effectiveness of GeoGebra and its MVP key features in science and engineering, particularly in topics related to mathematics. Each key feature of GeoGebra is thoroughly analyzed, and further analyses, along with how GeoGebra can be helpful in different topics, are discussed.