The collision force of a heavy rail transit vehicle hitting a bridge pier is affected by many factors. In order to investigate the characteristics of the collision force when a heavy rail transit vehicle hits a bridge, the finite element software LS-DYNA is used to simulate the impact of a heavy rail transit vehicle on a bridge. The influence of the vehicle speed of heavy rail transit vehicles, the strength of bridge pier concrete, the spacing of pier stirrups, the ratio of pier stirrup reinforcement, and the eccentric distance between the vehicle and the bridge pier on the characteristics of the collision force. The simulation analysis results show that the total deformation frequency around the impact point of the bridge pier and the heavy rail transit vehicle decreases as the distance from the impact point increases, and the deformation frequency in the vicinity of the impact point is the largest. The speed of the heavy rail transit vehicle, the concrete strength of the bridge pier, the reinforcement ratio of the pier stirrup, the larger the eccentric distance between the vehicle and the bridge pier, and the smaller the spacing between the stirrups, the greater the collision force when the heavy rail transit vehicle hits the bridge pier.