Analysis and prediction model of ferroptosis related genes in breast cancer

Abstract

Background: The prognosis of patients with breast cancer (BRCA) is difficult to predict because of the high degree of heterogeneity and complex etiological factors. Ferroptosis, an iron-dependent, new form of cell death, plays an important role in regulation of tumor growth and progression. The aim of this study was to clarify the predictive value of ferroptosis-related genes in the overall survival of patients with BRCA. Methods:The messenger RNA expression profile and clinical information of patients with BRCA were collected from The Cancer Genome Atlas (TCGA) database. The differences between BRCA and adjacent normal tissues were analyzed, and candidates with differentially expressed ferroptosis-related genes were identified. Through Cox and LASSO analyses, the prognostic genetic characteristics of ferroptosis-related genes were established. Lastly, according to the median risk score, the patients were divided into high-risk and low-risk groups, a nomogram was constructed, and the prediction accuracy was tested.Results: It was determined that the four ferroptosis related genes had a significant difference in survival in BRCA (P<0.05); a prognostic model was constructed based on the four ferroptosis related genes, and the overall survival of patients in the high-risk group was significantly worse (P<0.05). The four-gene nomogram can quantify the contribution of each index to survival, and the calibration chart shows high prediction accuracy.Conclusions: This study constructed four ferroptosis related gene characteristics and nomogram, which can effectively predict the prognosis of BRCA patients and provide new insights for future anti-cancer treatments based on ferroptosis targets.

Engineering Fe/Mn-doped zinc oxide nanosonosensitizers for ultrasound-activated and multiple ferroptosis-augmented nanodynamic tumor suppression

“…In the ferroptosis program, ROS produced by Fenton reaction damaged the cell membrane and mitochondria, and Fe 3+ prevented GSH from protecting cell membrane and mitochondria [ 41 , 47 , 48 ]. Herein, the Fe 2+ and Mn 2+ in the doping nanostructure triggered Fenton reaction in the presence of H 2 O 2 , then the produced Fe 3+ and Mn 4+ enhanced GSH consumption effect.…”

Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer

“…Research showed that SHARPIN promoted cholangiocarcinoma cell proliferation and inhibited ferroptosis via p53/SLC7A11/ GPX4 signaling [50]. In addition, ferroptosis related elements was identified as potential predictive markers for a variety of cancers, such as liver cancer [51] and breast cancer [52,53]. Immunotherapies are now targeting more than just the CTLA-4 or PD-1 related pathways.…”

Ferroptosis biomarkers predict tumor mutation burden's impact on prognosis in HER2-positive breast cancer

“…Notably, not all patients derive equal benefits from existing anti-HER2 therapies, and HER2-positive BC is inherently heterogeneous. Although numerous studies have focused on investigating the prognostic significance of ferroptosis-related genes in BC[ 8 - 10 ], analyses specific to BC subtypes are lacking. A more comprehensive understanding of tumor biology and the HER2 signaling pathway is essential for advancing novel strategies to improve patient outcomes.…”