Analysis by liquid chromatography and infrared spectrometry of di(2-ethylhexyl)phthalate released by multilayer infusion tubing

Bourdeaux, Daniel; Sautou, V.; Bagel-Boithias, Sandrine; Boyer, Anne; Chopineau, J.

doi:10.1016/j.jpba.2003.12.018

Cited by 33 publications

(23 citation statements)

References 13 publications

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“…1 The major problem of the PVC bags for drug infusion purpose is that di-(2-ethylhexyl) phthalate (DEHP), the main plasticizer used in manufacturing PVC bags, can leach into the infusion solutions. [2][3][4][5][6] DEHP, when injected into the human patients, may have adverse effects on their bodies including chronic toxicities on the liver and the reproductive systems. [5][6][7] To overcome these problems, several types of non-PVC bags comprised of polyolefins, such as polyethylene and polypropylene (PP), have been developed.…”

Section: Introductionmentioning

confidence: 99%

Compatibility of diazepam with polypropylene multilayer infusion container

et al. 2009

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Techflex ® , a polypropylene-lined, multilayer infusion bag, was studied for its compatibility with diazepam, in comparison to the conventional infusion bag, Safeflex ® , which is comprised of poly(vinyl chloride) (PVC). Diazepam was diluted in 0.9% sodium chloride isotonic solution and stored in the infusion bags for 24 h. To evaluate the sorption of diazepam into the infusion bags during storage, the concentration of the drug remaining in the bag was measured using gas chromatography-mass spectroscopy. The PVC bags exhibited a marked sorption of diazepam, with a drug loss reaching up to 90% of the initial concentration after 24 h of contact, whereas Techflex ® inhibited the drug sorption, showing approximately 10%, under the same conditions. The differences in the sorption behaviors of the bags are discussed in terms of solubility parameters and crystallinities of the polymers.

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Section: Introductionmentioning

confidence: 99%

Compatibility of diazepam with polypropylene multilayer infusion container

et al. 2009

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“…However, the rate of plasticizer migration does not change linearly with time. The study by D. Bourdeaux et al, carried out on 150 cm extension lines in contact with Polysorbate 80®, showed that the release of plasticizers was very high in the first 24 hours then decreased [22]. These results are supported by Chellini et al, who demonstrated DEHP release from endoctracheal tubings in the early hours of intubation [24].…”

Section: The Contact Conditions Between the MD And The Fluid In A Climentioning

confidence: 86%

“…These two parameters, which are often inseparable, considerably influence the release of plasticizers. The work carried out on DEHP by Loff [22], and Kambia in 2003 [23] shows that exposure to phthalate increases with the contact time between the PVC container and the contents until the exhaustion of the phtalate in the material. However, the rate of plasticizer migration does not change linearly with time.…”

Section: The Contact Conditions Between the MD And The Fluid In A Climentioning

confidence: 99%

Migration of plasticizers from PVC medical devices: Development of an infusion model.

Bernard

Cueff

Chagnon

et al. 2015

International Journal of Pharmaceutics

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“…Além disso, o pico localizado em 1230 cm -1 , se presente, encontra-se sobreposto por um pico muito intenso em 1270 cm -1 , correspondente ao plastificante DOP [20,21] , presente em todas as formulações estudadas. Entretanto, um exame cuidadoso dos espectros de FT-IR das formulações F7 (10 pcr de resina epóxi, denotada 10:0) e F9 (10 pcr de resina epóxi + 10 pcr de amino acelerador, denotada 10:10), apresenta indícios de um pico na região entre 3300 e 3500 cm -1 , correspondente ao grupo hidroxila.…”

Section: Figuraunclassified

Reticulação de plastissóis de PVC utilizando resina epóxi polifuncional: Síntese e caracterização

Carvalho¹,

Mei²,

Rodolfo³

2013

Polímeros

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Resumo: Plastissois reticulados de PVC foram obtidos por meio de espalmagem, na presença de uma resina epóxi polifuncional tipo tetraglicidilmetilenodianilina (TGMDA). A presença de um amino acelerador, baseado numa poliaminoamida comercial, mostrou-se imprescindível para a ocorrência de reticulação das cadeias do PVC. Resultados de grau de reticulação mostraram que só houve formação de gel nas amostras onde o amino acelerador foi utilizado concomitantemente com a resina epóxi, evidenciando uma sinergia entre ambos. Apesar dos resultados de módulo de Young sugerirem a formação de uma rede tridimensional entre as moléculas do PVC e a resina epóxi, a comprovação de uma reação química de reticulação entre o PVC e a resina epóxi não foi possível, devido ao grande numero de moléculas presentes na formulação final. Entretanto, a evidência de que a reticulação de fato ocorreu poderá vir de estudos mais detalhados e o uso de outras técnicas de caracterização complementares, já iniciados. Palavras-chave: PVC, poli(cloreto de vinila), plastissol, resina epóxi, polímeros hiperramificados, reticulação. Crosslinking of PVC Plastisols Using a Polyfunctional Epoxy Resin: Synthesis and CharacterizationAbstract: PVC plastisols, crosslinked in the presence of a polyfunctional epoxy resin, were obtained via spread coating. It was possible to infer that the presence of an amine type accelerator, at least in the conditions used in this study, proved to be essential for crosslinking. The results of reticulation degree showed that gel formation only happened in samples where the amine type accelerator has been used concomitantly with the epoxy resin. The results of Young's modulus seem to confirm the hypothesis of formation of a three dimensional network between the molecules of PVC and epoxy resin, but it was not possible to confirm a chemical reaction between these two polymers because of the large number of molecules present in the formulation. Evidence that crosslinking actually occurred may come from more detailed studies and the use of complementary characterization techniques, which are underway.

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Analysis by liquid chromatography and infrared spectrometry of di(2-ethylhexyl)phthalate released by multilayer infusion tubing

Cited by 33 publications

References 13 publications

Compatibility of diazepam with polypropylene multilayer infusion container

Compatibility of diazepam with polypropylene multilayer infusion container

Migration of plasticizers from PVC medical devices: Development of an infusion model.

Reticulação de plastissóis de PVC utilizando resina epóxi polifuncional: Síntese e caracterização

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