Analysis of 23 Y-STRs in a population sample from eastern Paraguay

Ribeiro, Julyana; Romero, Magdalena; Simão, Filipa; Almeida, Ana Paula F.; Quiroz, Alfredo; Machado, Patrícia; Velázquez, Vanessa; Carvalho, E.F.; Vullo, Carlos; Gusmão, Leonor

doi:10.1016/j.fsigen.2018.08.007

Cited by 8 publications

(7 citation statements)

References 13 publications

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“…Therefore, due to the high mobility detected between departments and the genetic homogeneity found among them, all samples were grouped as eastern Paraguay for further analyses. This genetic homogeneity across eastern Paraguay is in accordance with previous results from autosomal and Y-chromosomal STRs [8,9].…”

Section: Demography and Genetic Structure Of Eastern Paraguaysupporting

confidence: 92%

“…Nonetheless, to date, no extensive knowledge about the genetic diversity of Paraguay and its stratification has been developed, and only little research is available for a limited number of markers. Previous studies for both autosomal and Y-chromosomal STRs (Y-STRs) reported allele/haplotype frequencies for eastern Paraguay [8,9]. With these markers, no statistically significant differentiation was detected among departments in the eastern Paraguay region.…”

Section: Introductionmentioning

confidence: 89%

“…The Y-SNPs were selected to discriminate the most frequent haplogroups in African, Native American, European, and Asian populations. Y-STR haplotypes previously reported for these samples [9] were used for haplogroup prediction on Y-DNA Haplogroup Predictor NevGen [15]. This way, it was possible to direct genotyping and avoid extra typing.…”

Section: Genotyping Methodsmentioning

confidence: 99%

“…The sample size previously analyzed for mtDNA was enlarged [10], and this allowed for a more detailed tracking of the ethno-linguistic/geographic origin of the maternal lineages in Paraguay, in addition to the previous estimates on the ancestry from different continents. Moreover, specific Y chromosome SNPs (Y-SNPs) were genotyped for the samples previously studied for Y-STRs [9]. Although the results of the Y-STRs have shown a proximity between Paraguay and European populations, the exact proportion of European heritage is only possible with the classification of haplogroups based on Y-SNPs.…”

Section: Introductionmentioning

confidence: 99%

“…For the same samples, a set of 46 ancestry informative indels (AIM-InDels), located in autosomes, was also analyzed. Information on mtDNA, Y-SNPs and AIM-InDels was used to estimate differential maternal and paternal contributions and their variation within and across geographic regions more accurately than in previous studies [9,10]. Furthermore, the data obtained were used to track the origin of maternal and paternal lineages in more detail and to determine how migration patterns shaped the country's genetic makeup.…”

Section: Introductionmentioning

confidence: 99%

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The Ancestry of Eastern Paraguay: A Typical South American Profile with a Unique Pattern of Admixture

Simão¹,

Ribeiro²,

Vullo³

et al. 2021

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Immigrants from diverse origins have arrived in Paraguay and produced important demographic changes in a territory initially inhabited by indigenous Guarani. Few studies have been performed to estimate the proportion of Native ancestry that is still preserved in Paraguay and the role of females and males in admixture processes. Therefore, 548 individuals from eastern Paraguay were genotyped for three marker sets: mtDNA, Y-SNPs and autosomal AIM-InDels. A genetic homogeneity was found between departments for each set of markers, supported by the demographic data collected, which showed that only 43% of the individuals have the same birthplace as their parents. The results show a sex-biased intermarriage, with higher maternal than paternal Native American ancestry. Within the native mtDNA lineages in Paraguay (87.2% of the total), most haplogroups have a broad distribution across the subcontinent, and only few are concentrated around the Paraná River basin. The frequency distribution of the European paternal lineages in Paraguay (92.2% of the total) showed a major contribution from the Iberian region. In addition to the remaining legacy of the colonial period, the joint analysis of the different types of markers included in this study revealed the impact of post-war migrations on the current genetic background of Paraguay.

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Section: Demography and Genetic Structure Of Eastern Paraguaysupporting

confidence: 92%

Section: Introductionmentioning

confidence: 89%

Section: Genotyping Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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