Analysis of 35 cases of <scp>X</scp>anthogranulomatous pyelonephritis

Addison, Ben; Zargar, Homayoun; Lilic, Nikola; Merrilees, David; Rice, Michael

doi:10.1111/ans.12581

Cited by 37 publications

(58 citation statements)

References 19 publications

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“…The most common pathogens isolated with XGP are Proteus mirabilis and Escherichia coli, although other organisms have been isolated, as listed in Table 1 [12]. S. intermedius was isolated from the abscess culture in this case.…”

Section: Discussionmentioning

confidence: 83%

Xanthogranulomatous Pyelonephritis in a Surgically Complicated Patient: A Case Report

Kwon¹,

Greene²

2019

Journal of Microbiology and Infectious Diseases

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Xanthogranulomatous pyelonephritis is an uncommon destructive process that is associated with urinary tract infection and/or obstruction. We present the case of a 63 year old female who had an unusual case of xanthogranulomatous pyelonephritis due to Streptococcus intermedius in the left kidney. CT scan revealed a chronic obstructive pyelonephritis with associated staghorn calculi, and renal histopathology confirmed xanthogranulomatous pyelonephritis with foamy macrophages. She was a surgically complicated patient, who underwent two ventral hernia repairs along with her left nephrectomy. She ultimately had a complete recovery after surgical treatment and antibiotics.

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Section: Discussionmentioning

confidence: 83%

Xanthogranulomatous Pyelonephritis in a Surgically Complicated Patient: A Case Report

Kwon¹,

Greene²

2019

Journal of Microbiology and Infectious Diseases

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“…In one series, it was found to be the histopathological diagnosis in 20% of such cases [4]. Epidemiologically, it is found most commonly in women aged greater than 40 years old [4].…”

Section: Discussionmentioning

confidence: 99%

“…In one series, it was found to be the histopathological diagnosis in 20% of such cases [4]. Epidemiologically, it is found most commonly in women aged greater than 40 years old [4]. Diabetes mellitus, immune compromise, and abnormal lipid metabolism are also thought to be risk factors for developing this condition.…”

Section: Discussionmentioning

confidence: 99%

A Case of Xanthogranulomatous Pyelonephritis Associated with Renoduodenal Fistula

Holton-Burke

Varughese

2017

Case Reports in Medicine

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Xanthogranulomatous pyelonephritis (XGP) is a rare form of pyelonephritis associated with repeated infection, chronic inflammation, and obstruction. Various fistulas, including those to the intestine, are a known association with XGP. Here, a 55-year-old woman with a history of multiple previous renal calculi presented with dysuria and back pain. Contrast-enhanced computed tomography (CT) revealed a soft tissue density in her renal pelvis and perirenal space consistent with XGP along with a tract connecting the upper pole of her right kidney to the second portion of the duodenum. This finding was subsequently confirmed during percutaneous nephrostomy placement, stent placement, a small bowel follow-through study, and upper endoscopy. She was diagnosed with XGP with associated renoduodenal fistula, eventually treated by open nephrectomy with fistula takedown. Histopathologic analysis was consistent with the diagnosis of XGP with no malignant or infectious cause of the fistula. XGP should be considered in the diagnosis of patients with dysuria and back pain, especially when a history of obstruction or chronic inflammation. Associated fistulas should also be considered prior to surgical management to prevent complications.

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“…However it is primarily due to recurrent urinary tract infections following chronic obstruction of the urinary tract (5,12). Urinary calculi are the most common reason for the obstruction, being the cause in 70%-100% of patients, but they are not essential in making the diagnosis (3,4). Majority of renal calculi in XGPN are staghorn calculi, and are found in 50% of patients (3).…”

Section: Aetiologymentioning

confidence: 99%

“…XGPN commonly affects middle aged females (3)(4)(5)(6), especially during the fourth to sixth decades of life (7). But in children it has a male preponderance and mostly affects those under the age of 10 years (8).…”

Section: Introductionmentioning

confidence: 99%