Analysis of absorbed dose distribution in head phantom in boron neutron capture therapy

Marashi, M.K.

doi:10.1016/s0168-9002(99)00827-x

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Marashi (from NSTRI) initiated BNCT research in Iran in 1990s. Their research was about the use of a beam tube of Tehran Research Reactor (TRR) to produce a proper neutron beam for BNCT [109,116,117]. The results showed that the final neutron flux was not sufficient for BNCT.…”

Section: Jinst 12 P05005mentioning

confidence: 99%

Neutron beams implemented at nuclear research reactors for BNCT

2017

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A: This paper presents a survey of neutron beams which were or are in use at 56 Nuclear Research Reactors (NRRs) in order to be used for BNCT, either for treatment or research purposes in aspects of various combinations of materials that were used in their Beam Shaping Assembly (BSA) design, use of fission converters and optimized beam parameters. All our knowledge about BNCT is indebted to researches that have been done in NRRs. The results of about 60 years research in BNCT and also the successes of this method in medical treatment of tumors show that, for the development of BNCT as a routine cancer therapy method, hospital-based neutron sources are needed. Achieving a physical data collection on BNCT neutron beams based on NRRs will be helpful for beam designers in developing a non-reactor based neutron beam. K: Instrumentation for neutron sources; Instrumentation for particle-beam therapy 1Corresponding author.

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Section: Jinst 12 P05005mentioning

confidence: 99%

Neutron beams implemented at nuclear research reactors for BNCT

2017

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“…Boron Neutron Capture Therapy (BNCT) is a very effective cancer treatment technique for several types of brain tumor (Dao-wen et al 2012;Marashi 2000;Perks et al 1988). This technique is based on the bombardment of Boron with low energy thermal neutron that yields alpha particles ( 4 He) and recoiling lithium nuclei ( 7 Li).…”

Section: Introductionmentioning

confidence: 99%

Measurement of Neutron Flux and Gamma Dose Rate Distribution Inside a Water Phantom for Boron Neutron Capture Therapy Study at Dalat Research Reactor

Trinh¹,

Pham²,

Nhan³

et al. 2019

JSM

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Exposure dose rate to the tumor and surrounding cells during neutron beam irradiation in Boron Neutron Capture Therapy (BNCT) comes not only from heavy charged particles produced from the 10 B(n,α) 7 Li nuclear reaction, but also from neutron-induced reactions with other biological elements in living tissue, as well as from gamma rays leaked from the reactor core. At Dalat Research Reactor, Vietnam, the neutron and gamma dose rate distribution inside a water phantom were measured by using activation method and Thermoluminescent Dosimeter (TLD) detector, respectively. The results showed that effective thermal neutron dose rate along the center line of the water phantom had a maximum value of 479 mSv h -1 at 1 cm in phantom and then decreases rapidly to 4.87 mSv h -1 at 10 cm. The gamma dose rate along the center line of the water phantom also reach its maximum of 4.31 mSv h -1 at 1 cm depth and decreases to 1.16 mSv h -1 at 10 cm position. The maximum biological tumor dose rate was 1.74 Gy-eq h -1 , not high enough to satisfy the treatment requirement of brain tumors. However, the results of this work are important in supporting of BNCT study in the upcoming stages at Dalat Research Reactor. ABSTRAK Kadar dos pendedahan kepada tumor dan sel sekitarnya semasa pancaran sinaran neutron dalam Terapi Boron NeutronTertawan (BNCT) datang bukan sahaja daripada zarah berat bercas yang dihasilkan daripada tindak balas nuklear 10 B(n,α) 7 Li, tetapi juga daripada tindak balas neutron-teraruh daripada unsur biologi lain dalam tisu hidup, selain daripada sinar gama yang bocor daripada teras reaktor. Di Reaktor Penyelidikan Dalat, Vietnam, kadar pengagihan dos neutron dan gama dalam fantom air diukur masing-masing menggunakan kaedah pengaktifan dan pengesan Thermoluminescent Dosimeter (TLD). Keputusan menunjukkan bahawa kadar dos haba neutron yang berkesan sepanjang garis tengah fantom air mempunyai nilai maksimum 479 mSv h -1 pada 1 cm dalam phantom dan kemudian menurun dengan pantas kepada 4.87 mSv h -1 pada 10 cm. Kadar dos gama sepanjang garis tengah fantom air juga mencapai tahap maksimum 4.31 mSv h -1 pada kedalaman 1 cm dan menurun ke 1.16 mSv h -1 pada kedudukan 10 cm. Kadar dos maksimum tumor biologi adalah 1.74 Gy-eq h -1 namun tidak cukup tinggi untuk memenuhi keperluan rawatan tumor otak. Walau bagaimanapun, keputusan kajian ini adalah penting dalam menyokong pengajian BNCT pada peringkat akan datang di Reaktor Penyelidikan Dalat. Kata kunci: BNCT; fantom air; fluks haba neutron; kadar dos; pengesan TLD

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“…2013;Kato et.al, 2004) or deep-seated tumors (Rao et.al, 2004;Kageji, 2011;Yamamoto, 2004;Kawabata, 2009). While a thermal neutron beam (E<1eV) is suitable for treating shallow tumors, the irradiation of epithermal neutron beam (1 eV≤ E ≤ 10 keV) for treatment of deeper tissues is examined in the literature (IAEA-TECDOC, 2001;Kiger III et.al, 2009;Marashi, 2000). Since the suggested neutron sources for BNCT, such as nuclear reactors (Auterinen et.al, 2004;Ceballos and Esposito, 2009;Kiger III et.al, 2004), neutron generators (Durisi et.al, 2007;Verbeke et.al, 2000;Rasouli et.al, 2012), and accelerator based sources (Kononov et.al,.…”

Section: Introductionmentioning

confidence: 99%