Analysis of Admission Thromboelastogram Profiles in 1369 Male and Female Trauma Patients

Favors, Lauren E.; Harrell, Kevin N.; Miles, M Victoria P; Everett, Hayley; Rippy, Meredith; Maxwell, Robert A.

doi:10.1016/j.jss.2022.07.048

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…As described in Figure S6 (Supporting Information), the thromboelastogram (TEG) is a detective method to simulate the dynamic changes of blood coagulation in vitro, which has become an important index for monitoring blood coagulation function. [24] The R time in the whole blood TEG means the period from the start of blood clotting until the formation of fibrin clots, which is mainly affected by coagulation factors. As shown in Figure 5A, the CNC-TA-DA suspension shortened the R time by 67.83 ± 6.11% of that in the control group (Figure 5B), which meant that the mechanism was related to its ability to induce coagulation factor activation.…”

Section: Mechanisms Of Haemostatic Action In Cnc-ta-da/pdms Gauze-teg...mentioning

confidence: 99%

Ultra‐Hydrophobic Gauze Driving Super‐Haemostasis

Chen,

Yang,

Liu

et al. 2024

Adv Healthcare Materials

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Controlling bleeding by applying pressing cotton gauze is the most facile treatment in prehospital emergencies. However, the wettable nature of cotton fibers leads to unnecessary blood loss due to excessive blood absorption, inseparable adhesion‐induced pain, and pliable to infection. Here, we develop a kind of ultra‐hydrophobic haemostatic anti‐adhesive gauze whose surface is loaded with polydimethylsiloxane (PDMS) and hydrophobic‐modified cellulose nanocrystals (CNCs), achieving a water contact angle of about 160°. We demonstrate that the mechanism by which hydrophobic CNCs promote blood clotting is associated with their ability to activate coagulation factors, contributing to fibrin formation, and promoting platelet activation. The blood‐restricting effect results from the low surface energy layer formed by PDMS and then the alkyl chains of hydrophobic CNCs were combined. The produced ultra‐hydrophobic gauze resists blood flow and diffusion, decreases blood loss, is effortlessly peel‐able, and minimizes pathogen adhesion. Compared to the commercial cotton gauze, our gauze achieved effective haemostasis and antiadhesion by reducing blood loss by more than 90%, shortening haemostasis time by more than 75%, lowering peeling force by more than 90% and minifying bacterium attachment by more than 95%. Our work presents promising applications in terms of prehospital first aid.This article is protected by copyright. All rights reserved

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Section: Mechanisms Of Haemostatic Action In Cnc-ta-da/pdms Gauze-teg...mentioning

confidence: 99%