Analysis of anthelmintics in surface water by ultra high performance liquid chromatography coupled to quadrupole linear ion trap tandem mass spectrometry

Zrnčić, Mirta; Gros, Meritxell; Babić, Sandra; Kaštelan‐Macan, Marija; Barceló, Damià; Petrović, Mira

doi:10.1016/j.chemosphere.2013.10.091

Cited by 69 publications

(32 citation statements)

References 25 publications

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“…Unfortunately, regardless of the high usage of anthelmintics and their potential impact on living organisms in water, soil and sediment, the information on their concentrations in the environmental waters is scarce. Their presence in the environment in low g L −1 concentrations has been reported in [8][9][10][11][12] but despite the reported low concentrations, their ongoing input into the environment attracts interest. In that sense, it is necessary to develop more effective wastewater treatment technologies to prevent the emission of pharmaceuticals such as anthelmintics into the environment.…”

Section: Introductionmentioning

confidence: 98%

Kinetics and degradation pathways of photolytic and photocatalytic oxidation of the anthelmintic drug praziquantel

Čizmić

Ljubas

Ćurković

et al. 2017

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 98%

Kinetics and degradation pathways of photolytic and photocatalytic oxidation of the anthelmintic drug praziquantel

Čizmić

Ljubas

Ćurković

et al. 2017

Journal of Hazardous Materials

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“…1,4 A number of analytical methods have been described to determine TCB and its metabolites in different matrices. [5][6][7][8][9][10][11][12] The simultaneous determination of TCB and its metabolites has been reported in bovine and goat tissues by using an extraction of analytes from the tissues with acetonitrile, and then crude extracts are subjected to liquid-liquid extraction with n-hexane. 9,10 A traditional liquid-liquid extraction has also been described for separation/ determination of TCB from spiked human plasma using ethyl acetate.…”

Section: Introductionmentioning

confidence: 99%

Determination of Triclabendazole in Cattle Plasma as Its Sulphoxide and Sulphone Metabolites by Rotating Disk Sorptive Extraction Combined With High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Studies

Cañas-Müller

Campo

Richter

2016

J. Chil. Chem. Soc.

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In this study, a new method for determination of triclabendazole (TCB) as its main metabolites, triclabendazole sulfoxide (TCB-SO) and triclabendazole sulfone (TCB-SO 2 ) in animal plasma was developed. TCB is widely used as antiparasitic in the veterinary industry. Rotating disk sorptive extraction (RDSE) was the selected sample preparation technique for extraction/clean up of the compounds from the samples followed by high performance liquid chromatography coupled to diode array detection (HPLC-DAD) for quantification.Optimization of physicochemical variables was performed using a multivariate experimental design. Following the recommendations given in the Veterinary International Conference on Harmonization guides (VICH GL02 and VICH GL49), the validation of the method was performed, given rise to improved analytical features compared with those provided by other methods based on solid phase extraction (SPE). Linearity (r > 0.99) was achieved for both compounds when calibration was performed not only in standard solutions but also in animal spiked plasma. Selectivity, defined as the response ratio between blank and analyte at the limit of quantification, was 11.8% and 3.4% for TCB-SO and TCB-SO 2 , respectively. Accuracy and precision, expressed in percentage, were always lower than -16.7% and 8.1%, respectively. Eco-efficiency was quantitatively assessed indicating that the method is an excellent green method.The proposed analytical method was applied to the determination of the pharmacokinetic of two commercial products of TCB in cattle plasma after oral administration.The good analytical performance, eco-efficiency and economy, make the method interesting for alternative use in routine laboratories.

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“…[35] investigated the presence of anthelmintics in the waters of Llobregat River in Spain, which runs through a part of the country where there are numerous agricultural establishments, mainly pig farms. The authors found that out of ten anthelmintics analyzed, eight were detected in concentrations ranging between 0.32 and 39.43 ng/L and the most frequently detected one was levamisol with concentrations up to 39.43 ng/L.…”

Section: Occurrence Of Veterinary Pharmaceuticals In Aqueous Matrixmentioning

confidence: 99%

“…The authors found that out of ten anthelmintics analyzed, eight were detected in concentrations ranging between 0.32 and 39.43 ng/L and the most frequently detected one was levamisol with concentrations up to 39.43 ng/L. The study highlighted the highest cumulative anthelmintic total concentration in the sampling point corresponding to the discharge of the river to the Mediterranean Sea close to the city of Barcelona, which raises serious concerns due to the use of Barcelona beaches as recreational areas in the summer by many tourists [35]. …”

Section: Occurrence Of Veterinary Pharmaceuticals In Aqueous Matrixmentioning

confidence: 99%

The Occurrence of Veterinary Pharmaceuticals in the Environment: A Review

Kaczala

Blum²

2016

CAC

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It is well known that there is a widespread use of veterinary pharmaceuticals and consequent release into different ecosystems such as freshwater bodies and groundwater systems. Furthermore, the use of organic fertilizers produced from animal waste manure has been also responsible for the occurrence of veterinary pharmaceuticals in agricultural soils. This article is a review of different studies focused on the detection and quantification of such compounds in environmental compartments using different analytical techniques. Furthermore, this paper reports the main challenges regarding veterinary pharmaceuticals in terms of analytical methods, detection/quantification of parent compounds and metabolites, and risks/toxicity to human health and aquatic ecosystems. Based on the existing literature, it is clear that only limited data is available regarding veterinary compounds and there are still considerable gaps to be bridged in order to remediate existing problems and prevent future ones. In terms of analytical methods, there are still considerable challenges to overcome considering the large number of existing compounds and respective metabolites. A number of studies highlight the lack of attention given to the detection and quantification of transformation products and metabolites. Furthermore more attention needs to be given in relation to the toxic effects and potential risks that veterinary compounds pose to environmental and human health. To conclude, the more research investigations focused on these subjects take place in the near future, more rapidly we will get a better understanding about the behavior of these compounds and the real risks they pose to aquatic and terrestrial environments and how to properly tackle them.

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Analysis of anthelmintics in surface water by ultra high performance liquid chromatography coupled to quadrupole linear ion trap tandem mass spectrometry

Cited by 69 publications

References 25 publications

Kinetics and degradation pathways of photolytic and photocatalytic oxidation of the anthelmintic drug praziquantel

Kinetics and degradation pathways of photolytic and photocatalytic oxidation of the anthelmintic drug praziquantel

Determination of Triclabendazole in Cattle Plasma as Its Sulphoxide and Sulphone Metabolites by Rotating Disk Sorptive Extraction Combined With High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Studies

The Occurrence of Veterinary Pharmaceuticals in the Environment: A Review

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