Analysis of autofluorescence pattern in birdshot chorioretinopathy

Semecas, Rachel; Mauget‐Faÿsse, Martine; Aptel, Florent; Mailhac, Adriane; Salmon, L.; Vasseur, Vivien; Bouillet, Laurence; Chiquet, Christophe

doi:10.1007/s00417-017-3644-7

Cited by 12 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We observed that, as in other studies, hypoautofluorescent changes are frequent in BSCR with a predilection to a peripapillary distribution. 17,19,20,22,23 Unlike other studies, we specifically examined peripapillary hyperautofluorescence within our cohort and found this to also be common (about one-third of eyes), although not as prevalent as peripapillary hypoautofluorescence.…”

Section: Discussionmentioning

confidence: 82%

“…A case series by Semécas et al observed punctate hyperautofluorescence in all cases of active BSCR. 22 Hyperautofluorescence was associated with shorter duration of BSCR and hypoautofluorescence with longer disease duration by Böni and colleagues. 23 These findings support the idea that hyperautofluorescence may serve as a marker of earlier inflammatory changes.…”

Section: Discussionmentioning

confidence: 93%

“…Two case series have identified a correlation between hyperautofluorescence and EZ disruption 17 and hyperreflective microgranular structures at the level of the EZ and RPE. 22 In our index case prior to therapy, we identified outer retinal lesions that corresponded to regions of hypoautofluorescence with surrounding hyperautofluorescence. After treatment, despite improvement in the outer retinal lesions, autofluorescence in these regions progressed to uniform hypoautofluorescence.…”

Section: Discussionmentioning

confidence: 93%

“…Several other cases have been reported in which changes to the outer retina were reversible after treatment with immunosuppression. 17,22 Together, these findings point to outer retinal lesions as an important marker of potentially reversible retinal inflammation in BSCR that may directly affect vision.…”

Section: Discussionmentioning

confidence: 95%

“…Hypoautofluorescent lesions are commonly observed around the optic nerve and in macular and extramacular locations alike. [19][20][21][22][23] Different patterns of hypoautofluorescence have been described including placoid 20 and confluent or granular in perivascular, arcuate, descending tract, and peripapillary distributions. 23 Confluent hypoautofluorescence has been associated with longer duration of BSCR.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Association of Fundus Autofluorescence Findings and Outer Retinal Lesions on Optical Coherence Tomography With Visual Acuity in Birdshot Chorioretinopathy

Kopplin

Munk

Baynham

et al. 2019

Journal of VitreoRetinal Diseases

View full text Add to dashboard Cite

Purpose: This article investigates the optical coherence tomography (OCT) and fundus autofluorescence imaging findings in birdshot chorioretinopathy (BSCR) and their association with visual acuity (VA). Methods: In a retrospective, cross-sectional study, we evaluated OCT images for changes in retinal structure including cystoid macular edema (CME), epiretinal membrane, and outer retinal lesions. We assessed autofluorescence images for hypoautofluorescent and hyperautofluorescent changes and noted the distribution of the lesions. Demographic data and VA at the time of imaging were also collected. Associations between OCT and autofluorescence findings and logarithm of the minimum angle of resolution VA were tested using linear regression. Results: We conducted a chart review of 80 eyes from 40 patients with BSCR. Outer retinal lesions were found on OCT in 28 of 80 eyes (35%) and disruption of the outer segment ellipsoid zone (EZ) occurred in 23 eyes (28.7%). Macular hypoautofluorescent lesions were more common than hyperautofluorescent lesions, present in 58.8% and 13% of eyes, respectively. The presence of outer retinal lesions on OCT was significantly associated with reduced VA ( P = .006) as was EZ disruption ( P = .003). These associations remained significant after accounting for the presence of macular edema. There was a trend toward association of macular hypoautofluorescent lesions with decreased vision, although it was not statistically significant ( P = .17). Conclusions: The association of outer retinal lesions with decreased VA suggests a mechanism of central vision loss that is distinct from CME and may provide an additional objective finding to monitor disease activity in BSCR patients.

show abstract