Analysis of bioactive phytochemical compound of ( <i>Cyperus alternifolius</i> L.) By using gas chromatography –mass spectrometry

Al-Gara,awi, Neepal Imtair; Abu-Serag, Nidaa Adnan; Shaheed, Khansaa Abdul Alee; Bahadly, Zina Khalil Al

doi:10.1088/1757-899x/571/1/012047

Cited by 30 publications

(11 citation statements)

References 13 publications

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“…Similarly, amiodarone, hexadecanoic acid, and 2,3-dihydroxypropyl ester are also used as hypoglycemic agents either alone or in combination (Lai et al, 2020). Other antidiabetic compounds identified included, 1-Monolinoleoylglycerol trimethylsilyl ether (Senthil et al, 2016), vitamin E (Bharti et al, 2012), and Dasycarpidan-1-methanol, acetate (Al-Gara et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis and hypoglycemic potential of Filago hurdwarica (Wall. ex DC.) Wagenitz in alloxan induced diabetic mice

Rahman

Jan

et al. 2024

Braz. J. Biol.

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Plants have profound therapeutic benefits, more economical treatments, fewer side effects, and a relatively cheap cost, making them a source of drugs for protective, preventative, curative, or conducive purposes and creating novel phytomedicines. Plant derived medicines are relatively safe compared to synthetic medicines. Many plants have proved to successfully aid in the treatment of diabetes including Filago hurdwarica (Wall. ex DC.) Wagenitz. The current investigations were therefore designed to assess the phytochemical, antioxidant, antidiabetic, and antihyperlipidemic activities of F. hurdwarica. The phytochemical investigations and antioxidant activities of different extracts were carried out using standard chemical tests, DPPH, and H2O2 scavenging assays. F. hurdwarica plant extract in Hydromethanolic solution were prepared by Soxhletation method and stored in refrigerator at 4°C for two days before use. Swiss Albino mice were made diabetic by a single dose of alloxan (150 mg/kg). Hydromethanolic plant extract and fractions of F. hurdwarica were screened for antidiabetic activity and given to the alloxan-induced diabetic mice at a concentration of 150-250 mg/kg of body weight in different groups of 6 diabetic mice each orally once a day for 15 days. Glibenclamide is also given to another group to as a standard drug to support the result at a dose of 10 mg/kg of body weight orally once a day for 15 days. Blood glucose levels and body weights of mice were measured on 0, 4, 7, 11 and 15th days. The study found that the extract was safe up to the dose level of 2000 mg/kg and the dose response effect of chloroform extract (150-250 mg/kg) of F. hurdwarica showed expressive antihyperglycemic effects and also improved other altered biochemical parameters associated with diabetes. The FTIR and XRD spectra demonstrated the occurrence of phenols, alcohols, alkenes, alkyl halides, ketones, and aromatic compounds and confirmed the amorphous nature of the extract. GC-MS spectral analysis showed the tentative presence of 31 phytochemical constituents in the chloroform extract of F. hurdwarica with different retention time. To conclude, the chloroform extract (250 mg/kg) of F. hurdwarica revealed considerable antioxidant, antihyperglycemic, and antihyperlipidemic potential and is safe for treating diabetes and related complications.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis and hypoglycemic potential of Filago hurdwarica (Wall. ex DC.) Wagenitz in alloxan induced diabetic mice

Rahman

Jan

et al. 2024

Braz. J. Biol.

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“…The compound 9,12,15-Octadecatrienoic acid was known to possess several biological properties like analgesic, anesthetic, anticonvulsant, anti-inflammatory, antioxidant, anti-pyretic, antibacterial (Kalaivani et al 2012 ); anticancer, antihistaminic, hepatoprotective, hypocholesterolemic, nematicide (Rao et al 2019 ) in Andrographis paniculata and Carissa carandas and also known to reduce complications in Covid-19 patients (Weill et al 2020 ). α- d -Glucopyranoside, O -α- d -glucopyranosyl-β- d -fructofuranosyl, a phytochemical compound also found in Cyperus alternifolius have cardioprotective, neuroprotective, antidiabetic, antiosteoporotic, anti-inflammatory and antistress properties (Al-Gara et al 2019 ) . The 1,2-Propanediol, 3-(tetradecyloxy), a phytoconstituent reported to have antifungal activity (Sundberg and Faergemann, 2008 ), whereas the compound tert-Hexadecanethiol was known for its antitumor activity in Malaxis acuminta (Raval et al 2016 ); antioxidant, antifungal and insecticidal activities in Capsicum annuum (Sathya et al 2016 ).…”

Section: Discussionmentioning

confidence: 99%

GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts

2022

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Background Solanum khasianum is an important medicinal herb of the Solanaceae family. The present study was focused to determine the bioactive compounds in S. khasianum leaf and root extract by GC–MS analysis and their antibacterial activity by agar well diffusion method. Results Sixteen bioactive compounds were detected in leaf extract and thirty-two compounds in root methanolic extract by GC–MS. The major potent compounds identified in leaf and root extracts were heptadecane 9-hexyl (43.65%) and stigmasterol (23.18%). The root extract showed increased antibacterial activity than leaf extract. Conclusion These extracts possessed significant antibacterial activity against the tested bacterial isolates in dose-dependent manner. This study provides the phytoconstituents, antibacterial property and scientific evidence for the traditional claim and use of S. khasianum.

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“…The study showed that the alcohol extracts of plants treated with nano and biofertilizers and their interactions had an effect on inhibiting the growth of bacteria positive for Staphylococcus aureus and Gram negative bacteria for Pseudomonas aeruginosa in varying proportions, and the reason for the effect of the extract in inhibiting some bacterial activity may be The same anti-bacterial activity that appeared in the GC-MS gas chromatography examination, whose ratios differed according to the different treatments, as the detection of the compounds showed a The test also revealed the presence of Alpha-Amyrin which has anti-inflammatory properties [15], Also Benzofuran which has anti-bacterial properties [11], aside from compound Phthalic acid Which has high effectiveness in inhibiting the growth of bacteria [1], and compound Bis(2-ethylhexyl) phthalate It also has anti-bacterial properties [14].…”

Section: -Discussionmentioning

confidence: 84%

Antibacterial Activities For Root Extracts Of (goldenrods) Solidago Canadensis L Treated by Nano And Bio Fertilizer

Al-Rekaby¹,

ALhatemi

2020

Al-Qadisiyah Journal of Pure Science

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This experiment was done to find out to assess the effect of three concentration of Nano fertilizer 0, 1 and 2 gm./L , and the bio fertilizer at two levels 0 and 20 gm./L and their interactions on production of active ingredient of Solidago canadensis L. (goldenrods) , that planted in plastic pots. the active compounds in roots were measured After finishing experiment by Gas Chromatography-Mass Spectrometry (GC-MS) ( Manufacturer: Agilent 5977 A MSD , USA) The show results that the experimental treatment effect a significant increase in all measured parameters. Chemical description of extract has been carried out using gas chromatography and mass spectrometry (GC-MS). forty identified components in S. canadensis of total compounds in the fundamental compounds were identified as medical activity. The efficacy test included the effect of the alcohol extracts of the plant by inhibiting the growth of bacterial genera by the method of diffusion by drilling on the Mueller-Hunton medium. The laboratory experiment was carried out using Complete Randomized Design (CRD) with two factors (6 × 2) and three replicates for each treatment, the first factor, the type of extract for each plant treatment, and the second, the concentrations of the extract (100 and 200 mg / ml). The averages were compared when the differences were Significance using modified significance test RLSD with a significance level of 0.01. The results show : The higher level increased of concentration Benzofuran after treatment by 2 gm./L Nano fertilizer without Bio fertilizer, The higher level increased of concentration Stigmasta-7,16-dien-3-ol, (3.beta).after treatment by treatment 1 gm./L Nano fertilizer and 20 gm. /L Bio fertilizer , The higher level increased of concentration Phthalic acid after treatment by treatment 1 gm./L Nano fertilizer and 20 gm. /L Bio fertilizer , The higher inhibition diameter of Staphylococcus aureus after treatment by treatment 1 gm./L Nano fertilizer and 20 gm. /L Bio fertilizer , Which is Achieve 15.00 mm and The higher inhibition diameter of Pseudomonas aeruginosa after treatment by treatment 2 gm./L Nano fertilizer and 20 gm. /L Bio fertilizer , Which is Achieve 15.00 mm. Key wards : goldenrods , Solidago Canadensis , Bioactive constituents, Antibacterial activities, Root extracts, GC-MS , nanofertilizer and biofertilizer

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Analysis of bioactive phytochemical compound of ( Cyperus alternifolius L.) By using gas chromatography –mass spectrometry

Cited by 30 publications

References 13 publications

Phytochemical Analysis and hypoglycemic potential of Filago hurdwarica (Wall. ex DC.) Wagenitz in alloxan induced diabetic mice

Phytochemical Analysis and hypoglycemic potential of Filago hurdwarica (Wall. ex DC.) Wagenitz in alloxan induced diabetic mice

GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts

Antibacterial Activities For Root Extracts Of (goldenrods) Solidago Canadensis L Treated by Nano And Bio Fertilizer

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