Analysis of Certain Phenothiazines and Their Dosage Forms by Photometric Titration with Ceric Sulfate

A Novel Spectrophotometric Determination of Some Phenothiazines Involving Iodine monochloride from Chloramine‐T with Iodine

“…Phenothiazines in chemical analysis act as electron donors and, normally being oxidized to radical cations and thiazones [6], would provide a convenient basis for their kinetic and spectrophotometric studies in neutral and acidic media of organic solvent systems, involving Ce(IV) and Fe(III) as oxidants [7]. Considering the importance of phenothiazines in the pharmaceutical industry coupled with their interesting redox behavior, several analytical methods have been proposed for their determination which include titrimetry [8], thermometry [9], potentiometry [10], conductometry [11], chromatography [12Ϫ14], HPLC [15], capillary electrophoresis [16], polarography [17], photometry [18], Raman spectrometry [19], fluorimetry [20], flow injec-It appears from the literature that the spectrophotometry [24Ϫ28] is the most extensively employed method for the determination of phenothiazines, involving either solvent extraction as ion in association with bromophenol blue [29], eriochrome black-T [30], or redox reactions with a variety of oxidants; to name a few potassium periodate [31], tungstic acid [32], cobalt nitrite [33], potassium bromate [34], hydrogen peroxide [35], and iodic acid [36]. There are quite a good number of reviews on the determination of phenothiazines [37Ϫ39], and more methods seem to follow [40Ϫ42].…”