Analysis of Charged Cyclodextrin Derivatives by On-Line Capillary Electrophoresis-Ionspray-Mass Spectrometry

Tanaka, Yoshihide; Kishimoto, Yasuhiro; Terabe, Shigeru

doi:10.2116/analsci.14.383

Cited by 16 publications

(9 citation statements)

References 14 publications

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“…Table 1 (see Addendum) reports some selected examples of such application. Typically, carbohydrates carrying ionizable groups, like carrageenan oligosaccharides [51], or carboxymethylated and quaternary ammonium-CDs [47] are not derivatized. Neutral saccharides, on the contrary, are normally linked to negatively charged tags like p-amino benzoic acid (p-ABA) [42], 8-aminonaphthalene-1,3,6-trisulfonic acid (ANTS) [48], APTS [49], 7-amino-1,3-naphthalene disulfonic acid (ANDSA) [50] or, more rarely, to positively charged molecules, like 3-(acetylamino)-6-aminoacridone (AA-Ac) [52].…”

Section: Analysis Of Standard Mixturesmentioning

confidence: 99%

“…To date, the main articles regarding the CE-MS of saccharidic compounds found in literature include the analysis of (i) standard mixtures [42,[47][48][49][50][51][52]; (ii) carbohydrates in nutrition [19,[53][54][55][56][57][58][59]; (iii) glycans from glycoproteins [60][61][62][63][64][65]; (iv) carbohydrates in drug development [45,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81].…”

Section: Introductionmentioning

confidence: 99%

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Overview on advances in capillary electrophoresis‐mass spectrometry of carbohydrates: A tabulated review

et al. 2006

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Overview on advances in capillary electrophoresis-mass spectrometry of carbohydrates: A tabulated reviewThe increasing interest for carbohydrates as holder of essential bioinformations has boosted their full characterization through analytical techniques. The intent of this review is to summarize the recent trends regarding on-line and off-line CE-MS coupling for carbohydrate analysis. A statistical survey on the articles that use derivatizing agents as well as on the analyzer and type of instrument coupling (i.e. on-or off-line) is depicted. From a general overview it can be concluded that, whereas derivatization might be useful for the detection of neutral carbohydrates improving separation selectivity with volatile buffers and increasing sensitivity of the MS detection, relatively few works with derivatized carbohydrates were found; this was noticed in particular for glycosides and saccharides carrying ionizable groups, which are normally analyzed without any chemical modification. The most applied coupling is the on-line sheath-liquid interface; for online applications, ESI is the sole source used, whilst the most common analyzer is the IT. MS n is often exploited, as fragmentation increases the achieved structural information. CE-MS turned out to be mainly used for the analysis of carbohydrates in drug development (i.e. study of oligosaccharides from pathogens, carbohydrate-based drugs and drug metabolites), in nutrition and for characterization of glycans from glycoproteins. The reader will find elucidating tables regarding these recent CE-MS applications, including the main information on the analysis conditions. Comments are meant to help the immediate focus on the usefulness of the analytical technique and predict the difficulties found during analysis and, in case, their overcoming.

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Section: Analysis Of Standard Mixturesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Overview on advances in capillary electrophoresis‐mass spectrometry of carbohydrates: A tabulated review

et al. 2006

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“…The mass spectrum indicates the QA-␤-CD used in these experiments is primarily a mixture of mono-, di-, tri-, and tetra-(2-hydroxyl-3-trimethylammonium)-propyl substituted ␤-CD. Based on ESI-MS results for QA-␤-CD reported in the literature [36,37], albeit from another manufacturer, it is likely that more highly substituted derivatives of QA-␤-CD are present, but below detectable levels. The molecular ion for both I and II is observed at m/z 587 [I or II + Na + ] + (Fig.…”

Section: Binding Stoichiometry Of I and Ii With Qa-β-cdmentioning

confidence: 99%

Chiral separation of highly negatively charged enantiomers by capillary electrophoresis

Liu

Inoue

Kirchhoff

et al. 2004

Journal of Chromatography A

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“…Most of the derivatized CDs are present as mixtures of many isomeric forms differing in the degree of substitution [80,133] and in the position of the substituents [134]. This might become a problem in the sense that any batch-to-batch variability in selector production might limit the reproducibility of the analytical results obtained by them [46,135].…”

Section: Cdsmentioning

confidence: 99%

Fundamental aspects of chiral separations by capillary electrophoresis

2001

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A review is presented that surveys the basic theory of direct separation of enantiomers by capillary electrophoretic (CE) techniques. These separations are based on the formation of diastereomeric complexes between the enantiomeric analytes and a chiral selector added to the electrolyte solution. The review covers a comprehensive treatment of the equations needed for optimization of selectivity coefficients, resolution and analysis time in the zone electrophoretic mode. In this context, it takes into account combined equilibria of complexation and protonation/deprotonation as well as complexation and paritition into micelles. On the basis of these equations, the benefits of charged selectors and the optimization potential inherent to pH tuning can be documented. In addition, the review deals with some basic aspects of chiral isoelectric focusing and briefly discusses indirect enantioseparation. In a subsequent section a survey is given on particularfeatures of the various types of chiral selectors. Finally, the recent developments in preparative enantioseparation in continuous free-flow system and by use of isoelectric membranes are discussed.

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Analysis of Charged Cyclodextrin Derivatives by On-Line Capillary Electrophoresis-Ionspray-Mass Spectrometry

Cited by 16 publications

References 14 publications

Overview on advances in capillary electrophoresis‐mass spectrometry of carbohydrates: A tabulated review

Overview on advances in capillary electrophoresis‐mass spectrometry of carbohydrates: A tabulated review

Chiral separation of highly negatively charged enantiomers by capillary electrophoresis

Fundamental aspects of chiral separations by capillary electrophoresis

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