Analysis of Choroidal Thickness Using Spectral-Domain OCT in Children With Unilateral Amblyopia

Kara, Özgür; Altıntaş, Özgül; Karaman, Suleyman Korhan; Emre, Esra; Çağlar, Yusuf

doi:10.3928/01913913-20150311-11

Cited by 21 publications

(16 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, we found that SFCT was significantly greater in amblyopic eyes compared with the normal fellow eyes (399.25 ± 4.944 µm vs. 280.58 ± 6.491 µm, respectively). This result is similar to the findings reported by Kara O . Moreover, using SSADA‐OCT, the CC was shown to atrophy in amblyopic eyes.…”

Section: Discussionsupporting

confidence: 91%

In vivo optical imaging of amblyopia: Digital subtraction autofluorescence and split-spectrum amplitude-decorrelation angiography

et al. 2016

View full text Add to dashboard Cite

This is the first report of amblyopia using SSADA-OCT and digital subtraction images of autofluorescence. The mechanistic relationship of a thicker choroid and choroidal capillary atrophy with amblyopia remains to be described. The digital subtraction image confirmed the changes in the microstructure of the amblyopic retina as a supplementary approach to detect the progression of amblyopia. Lasers Surg. Med. 48:660-667, 2016. © 2016 Wiley Periodicals, Inc.

show abstract

Section: Discussionsupporting

confidence: 91%

In vivo optical imaging of amblyopia: Digital subtraction autofluorescence and split-spectrum amplitude-decorrelation angiography

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Kara et al [12] thought that amblyopia affected the process of postnatal maturation of the choroids and that amblyopia was associated with changes in choroidal function in humans. With split-spectrum amplitude-decorrelation angiography OCT, Guo et al [2] discovered that 86.4% of the amblyopic eyes displayed a blurry choroidocapillary network and that 68.2% of the amblyopic eyes had a dark atrophic patch.…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of Choroidal Thickness Changes in Unilateral Amblyopia

Zhao

2017

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose To date, the topic of amblyopic changes remains controversial. Therefore, a systematic review and meta-analysis were carried out to evaluate choroidal changes in unilateral amblyopia. Methods Major literature databases were searched for amblyopia-relevant studies. Using enhanced depth imaging optical coherence tomography (EDI-OCT), the primary outcome parameters examined were subfoveal choroidal thickness (SFCT) and different choroidal thickness (CT) positions. Efficacy estimates were evaluated by weighted mean difference (WMD) and 95% confidence interval (CI) for choroidal-associated changes. We performed subgroup analysis and metaregression analysis to examine potential sources of heterogeneity. Results Eleven cross-sectional studies that included a total of 768 participants were identified. The amblyopic eye SFCT was thicker than that of the fellow and control (normal) eyes (WMDamblyopia versus fellow = 49.24, 95% CI of 30.22 to 68.27, p < 0.001; WMDamblyopia versus control = 54.51, 95% CI of 32.17 to 76.85, p < 0.001). There were no differences between the fellow and control eyes (WMD = 13.81, 95% CI of 1.16 to 28.77, p = 0.071). Subgroup and metaregression analyses indicated that the OCT type was the main source of heterogeneity. Conclusions The CT in the amblyopic eyes was thicker than that in the fellow and control eyes.

show abstract

“…Many other investigators have reported that the SFCT in amblyopic eyes was greater than that of the fellow eyes with hypermetropic anisometropic amblyopia [ 17 – 22 ]. However, there are only a few studies that have examined the choroidal thickness in accordance with the amblyopic cause [ 17 , 18 , 22 ]. Similar to that for retinal thickness, whether "amblyopia influences" [ 13 , 17 ] or "refraction influences" [ 40 ] are associated with the choroid thickening in amblyopic eyes remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography

et al. 2017

View full text Add to dashboard Cite

BackgroundTo investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT).MethodsThis study examined 31 patients with hyperopic anisometropic amblyopia (6.9 ± 3.8 years, mean ± standard deviation), 15 patients with strabismic amblyopia without anisometropia (7.9 ± 4.2 years), and 24 age-matched controls (7.8 ± 3.3 years). Retinal and choroidal thickness was measured by 3D scans using SS-OCT. A 6-mm area around the fovea was automatically analyzed using the Early Treatment Diabetic Retinopathy Study map. The thickness from SS-OCT was corrected for magnification error using individual axial length, spherical refraction, cylinder refraction, and corneal radius. Retinal thickness was divided into the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCL+IPL), ganglion cell complex (GCC), and the inner limiting membrane to the retinal pigment epithelium (ILM-RPE) thickness. Retinal and choroidal thickness was compared among amblyopic, fellow, and normal eyes.ResultsIn both amblyopia groups, there was no significant difference in the mRNFL, GCL+IPL, and GCC thicknesses among the amblyopic, fellow, and control eyes. In the anisometropic amblyopia group, choroidal thickness (subfovea, center 1 mm, nasal and inferior of the inner ring, nasal of the outer ring, and center 6 mm) of amblyopic eyes were significantly greater than that of fellow and normal eyes. In contrast, none of the choroidal thicknesses were significantly different among the investigated eyes in the strabismic amblyopia group.ConclusionsWe found no significant difference in inner retinal thickness in patients with unilateral amblyopia. Although there were significant differences in choroidal thickness with hyperopic anisometropic amblyopia, there was no significant difference for the strabismic amblyopia. The discrepancy in choroidal thickness between the two types of amblyopia may be due to both differences in ocular size and underlying mechanism.

show abstract

Analysis of Choroidal Thickness Using Spectral-Domain OCT in Children With Unilateral Amblyopia

Cited by 21 publications

References 35 publications

In vivo optical imaging of amblyopia: Digital subtraction autofluorescence and split-spectrum amplitude-decorrelation angiography

In vivo optical imaging of amblyopia: Digital subtraction autofluorescence and split-spectrum amplitude-decorrelation angiography

A Meta-Analysis of Choroidal Thickness Changes in Unilateral Amblyopia

Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography

Contact Info

Product

Resources

About